The Evolution of REM Sleep Behavior Disorder in Early Parkinson Disease

Sixel‐Döring, Friederike; Zimmermann, Johannes; Wegener, Andrea; Mollenhauer, Brit; Trenkwalder, Claudia

doi:10.5665/sleep.6102

Cited by 85 publications

(57 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subjects with isolated increased EMG activity have been reported to develop clinical RBD at follow‐up . Alternatively, one study found that 7% of healthy controls with RBEs and apparently normal EMG activity developed RBD after 2 years . Similarly, a patient with REM sleep without atonia (RSWA) developed dementia with Lewy bodies 3 years later .…”

Section: Discussionmentioning

confidence: 99%

A case–control–family study of idiopathic rapid eye movement sleep behavior disorder

Liu

Zhang

Lam

et al. 2019

Annals of Neurology

View full text Add to dashboard Cite

Objective: To determine the familial aggregation of idiopathic rapid eye movement sleep behavior disorder (iRBD), neurodegenerative diseases, and related biomarkers. Methods: A total of 404 and 387 first-degree relatives of 102 patients with iRBD and of 89 controls were recruited, respectively. Among them, 204 and 208 relatives of patients and controls underwent face-to-face clinical assessment, whereas 97 and 75 relatives underwent further video-polysomnographic assessment, respectively. Results: Compared with relatives of controls, relatives of patients demonstrated higher levels of RBD features, including chin tonic electromyography activity (mean = 1.5 AE 7.5 vs 0.3 AE 1.0, p = 0.04) and behavioral events (n [weighted %] = 12 [11.3] vs 2 [1.9], adjusted hazard ratio [aHR] = 7.69, 95% confidence interval [CI] = 1.54-33.33, p = 0.009) during rapid eye movement sleep, probable diagnosis (n [%] = 57 [14.9] vs 20 [4.9], aHR = 3.45, 95% CI = 1.96-6.25, p < 0.001), and definite diagnosis (n [weighted %] = 10 [8.4] vs 2 [1.4], aHR = 5.56, 95% CI = 1.16-25.00, p = 0.03). They also had higher risks of Parkinson disease (3.1% vs 0.5%, aHR = 5.88, 95% CI = 1.37-25.00, p = 0.02), dementia (6.9% vs 2.6%, aHR = 2.44, 95% CI = 1.15-5.26, p = 0.02), constipation (8.3% vs 2.4%, adjusted odds ratio = 4.21, 95% CI = 1.34-13.17, p = 0.01), and motor dysfunction (Movement Disorders Society Unified Parkinson's Disease Rating Scale part III motor score, mean = 1.9 AE 3.2 vs 0.9 AE 2.3, p = 0.002). The unaffected relatives of patients demonstrated a higher likelihood ratio of prodromal Parkinson disease (median [interquartile range] = 0.27 [1.19] vs 0.22 [0.51], p = 0.03). Interpretation: iRBD is familially aggregated from isolated features to full-blown sleep disorder. Relatives of patients carry a higher risk of alpha-synucleinopathy in terms of neurodegenerative diseases and prodromal markers, suggesting a familial aggregation and staging pathology of alpha-synucleinopathy.

show abstract

Section: Discussionmentioning

confidence: 99%

A case–control–family study of idiopathic rapid eye movement sleep behavior disorder

Liu

Zhang

Lam

et al. 2019

Annals of Neurology

View full text Add to dashboard Cite

show abstract

“…Furthermore, three out of the six patients with ICDs who failed to show RSWA at v-PSG (8% of the total group) reported a typical history of dream-enacting behaviours, with two of them presenting brief REM sleep behavioural events during v-PSG, suggesting a ‘minor’ RBD, which is not uncommon in patients with PD 8. This condition was recently shown to represent a ‘prodromal RBD’ in a cohort of patients with PD prospectively assessed over a 2-year period 24. Thus, when pooling patients with v-PSG-confirmed RBD (n=34) and those with ‘minor’ RBD, the cumulative frequency of RBD in patients with ICDs rose to 93%.…”

Section: Discussionmentioning

confidence: 99%

Sleep and REM sleep behaviour disorder in Parkinson’s disease with impulse control disorder

Fantini

Figorilli

Arnulf

et al. 2017

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

show abstract

“…All subjects underwent a cardiorespiratory video‐supported PSG (Xltec: Excel Tech Ltd) according to American Academy of Sleep Medicine (AASM) criteria on two consecutive nights; RBD was diagnosed according to criteria established by Schenck et al and the International Classification of Sleep Disorders, 2nd edition (ICSD 2) . For details, see Sixel‐Doring et al…”

Section: Methodsmentioning

confidence: 99%

“…All subjects underwent a cardiorespiratory video-supported PSG (Xltec: Excel Tech Ltd) according to American Academy of Sleep Medicine (AASM) criteria on two consecutive nights; RBD was diagnosed according to criteria established by Schenck et al 10 and the International Classification of Sleep Disorders, 2nd edition (ICSD 2). 11 For details, see Sixel-Doring et al 2,12 REM without atonia was quantified by surface EMG activity of the mentalis muscle during REM sleep according to the method published by the SINBAR group and the cut-off value for 100% specificity was set at a mentalis EMG activity rate of 18.2%. 23 For diagnosis of RBD, study subjects needed to show REM associated motor behavior and/or vocalizations plus an EMG activity rate above the specific cut-off.…”

Section: Polysomnographymentioning

confidence: 99%

The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease

Halsband¹,

Zapf²,

Sixel‐Döring

et al. 2018

Movement Disord Clin Pract

Self Cite

View full text Add to dashboard Cite

BackgroundRapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD).ObjectivesTo test the validity of the RBD‐Screening Questionnaire (RBDSQ) in assessing RBD in early PD.MethodsThe RBDSQ was completed before video‐supported polysomnography (vPSG) by 134 de novo PD patients, 109 matched controls without neurological disorder (CTR) and 30 subjects with idiopathic RBD (iRBD) without clinical signs of PD; results were compared with vPSG‐confirmed RBD diagnosis.Results and ConclusionsSensitivity/specificity of the RBDSQ for the PD cohort were 0.44/0.84 at the previously published cut‐off score of 6 for PD patients, and the area under the curve (AUC) 0.68 (95% CI, 0.56–0.79). By contrast, in the iRBD/CTR cohort the RBDSQ (cut‐off = 5) had a sensitivity/specificity of 0.97/0.84 and an AUC of 0.95 (95% CI, 0.90–1.00). Subanalysis of question 6 only (4 subitems asking for dream enactment) at a cut‐off score of 1 revealed a sensitivity of 0.74 and a specificity of 0.70 for the de novo PD cohort, AUC was 0.74 (95% CI, 0.63–0.84). RBDSQ is an insufficient screening tool for RBD in de novo PD. New screening tools for RBD assessment need to be developed.

show abstract

The Evolution of REM Sleep Behavior Disorder in Early Parkinson Disease

Cited by 85 publications

References 25 publications

A case–control–family study of idiopathic rapid eye movement sleep behavior disorder

A case–control–family study of idiopathic rapid eye movement sleep behavior disorder

Sleep and REM sleep behaviour disorder in Parkinson’s disease with impulse control disorder

The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease

Contact Info

Product

Resources

About