The Evolutionary Dynamics of Human Influenza B Virus

Chen, Rubing; Holmes, Edward C.

doi:10.1007/s00239-008-9119-z

Cited by 217 publications

(230 citation statements)

References 35 publications

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“…Viral populations that are too diverse have the potential to cause high morbidity because hosts are unlikely to have immunity against many antigenic variants. Influenza subtypes H1N1 and B evolve antigenically slower than H3N2 but have greater genetic (and in the case of B, antigenic) diversity at any time [34,38,43,44] Thus, we chose to examine whether vaccination, by affecting antigenic evolution, could also impact diversification.…”

Section: Modeling Approach and Choice Of Parametersmentioning

confidence: 99%

The beneficial effects of vaccination on the evolution of seasonal influenza

Wen

Malani

Cobey

2017

Preprint

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Although vaccines against seasonal influenza are designed to protect against currently circulating strains, they may also affect the emergence of antigenically divergent strains and thereby change the rate of antigenic evolution. Such evolutionary effects could change the benefits that vaccines confer to vaccinated individuals and the host population (i.e. private and social benefits). To investigate vaccinations potential evolutionary impacts, we simulated the dynamics of an influenza-like pathogen in an annually vaccinated host population. On average, vaccination decreased the cumulative amount of antigenic evolution of the viral population and the incidence of disease. Vaccination at a 5% random annual vaccination rate (48% cumulative vaccine coverage after 20 years) decreased cumulative evolution by 56% and incidence by 76%. To understand how the evolutionary effects of vaccination might affect its private and social benefits over multiple seasons, we fit linear panel models to simulated infection and vaccination histories. Including the evolutionary effects of vaccination lowered the private benefits by 14% but increased the social benefits by 30% (at a 5% annual vaccination rate) compared to when evolutionary effects were ignored. Thus, in the long term, vaccines' private benefits may be lower and social benefits may be greater than predicted by current measurements of vaccine impact, which do not capture long-term evolutionary effects. These results suggest that conventional vaccines against seasonal influenza could greatly reduce the burden of disease by slowing antigenic evolution like universal vaccines. Furthermore, vaccination's evolutionary effects compound a collective action problem, highlighting the importance on social policies concerning vaccination.

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Section: Modeling Approach and Choice Of Parametersmentioning

confidence: 99%

The beneficial effects of vaccination on the evolution of seasonal influenza

Wen

Malani

Cobey

2017

Preprint

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“…It has been suggested that influenza type B and the influenza A (H1N1) subtype have slower antigenic evolution and fewer epidemic episodes, resulting in fewer global movements, compared with influenza A/H3N2. A complex network of interacting factors such as viral evolution, epidemiology and human behaviour may describe different patterns of global circulation among influenza viruses 6, 19…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of influenza B in Australia: 2001‐2014 influenza seasons

Moa

Muscatello

Turner

et al. 2016

Influenza Resp Viruses

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BackgroundInfluenza B is characterised by two antigenic lineages: B/Victoria and B/Yamagata. These lineages circulate together with influenza A during influenza seasons, with varying incidence from year to year and by geographic region.ObjectiveTo determine the epidemiology of influenza B relative to influenza A in Australia.MethodsLaboratory‐confirmed influenza notifications between 2001 and 2014 in Australia were obtained from the Australian National Notifiable Diseases Surveillance System.ResultsA total of 278 485 laboratory‐confirmed influenza cases were notified during the study period, comprising influenza A (82.2%), B (17.1%) and ‘other and untyped’ (0.7%). The proportion of notifications that were influenza B was highest in five‐ to nine‐year‐olds (27.5%) and lowest in persons aged 85 years and over (11.5%). Of all B notifications with lineage determined, 77.1% were B/Victoria and 22.9% were B/Yamagata infections. Mismatches between the dominant B lineage in a season and the trivalent vaccine B lineage occurred in over one‐third of seasons during the study years. In general, influenza B notifications peaked later than influenza A notifications.ConclusionThe proportion of circulating influenza B in Australia during 2001‐2014 was slightly lower than the global average and was dominated by B/Victoria. Compared with influenza A, influenza B infection was more common among older children and young adults and less common in the very elderly. Influenza B lineage mismatch with the trivalent vaccine occurred about one‐third of the time.

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“…En 1942, fue reemplazada por la vacuna bivalente y, en 1978, por las vacunas trivalentes contra la influenza (TIVs, del inglés trivalent influenza vaccines) 47 . Desde 2001, los linajes Victoria e Yamagata de la influenza B han co-circulado globalmente, pero las TIVs contienen solamente una cepa B 48 . Además, en seis de las últimas 12 temporadas, la cepa de linaje B, seleccionada por la OMS/CDC no concordó con la cepa circulante de linaje B 49 .…”

Section: Razones De Ser De Las Vacunas Cuadrivalentes Contra La Influunclassified

Hacia un mejor control de la influenza mediante la vacunación

Arlant

Bricks

2015

Rev. chil. infectol.

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ResumenEl 27 de agosto de 2014, la Sociedad Latinoamericana de Infectología Pediátrica (SLIPE) organizó la Conferencia Magistral sobre el tema "Hacia un Mejor Control de la Influenza mediante la Vacunación", un panel con especialistas internacionales en influenza, quienes compartieron su respectiva comprensión de la enfermedad y de las medidas de control disponibles, focalizando las informaciones más recientes sobre esta grave afección. En su informe, las Dras. Falleiros y Bricks resumieron los siguientes temas: Epidemiología global de la influenza, presentado por el Dr. Puig-Barbera; Recomendaciones sobre la vacuna contra la influenza y cobertura en los países de América Latina, presentado por la Dra. Bricks; Eficacia y efectividad de las vacunas contra la influenza, presentado por el Dr. Fedson; Impacto de la influenza y razones para la prevención en niños, presentado por el Dr. Muñoz; Efecto de la influenza en la gravidez, presentado por el Dr. Ribeiro; Vacunación contra la influenza en personal dedicado a cuidados de la salud, presentado por el Dr. Macías; Vacunación contra la influenza en los ancianos, presentado por el Dr. Ribeiro; Razones para aumentar las tasas de cobertura de la vacunación, Red Global de Vigilancia de la influenza en hospitales, presentado por el Dr. Puig-Barbera; Epidemiología de la influenza B y no equiparación de cepas de vacunas en la Región de América Latina, presentado por la Dra. Bricks; Modelaje para el impacto de las vacunas cuadrivalentes contra la influenza, presentado por el Dr. Blank; Razones de las vacunas cuadrivalentes contra la influenza y desarrollo clínico de QIVs, presentado por el Dr. Desauziers.Palabras clave: Influenza, vacuna, inmunización, protección del grupo de inmunización.

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The Evolutionary Dynamics of Human Influenza B Virus

Cited by 217 publications

References 35 publications

The beneficial effects of vaccination on the evolution of seasonal influenza

The beneficial effects of vaccination on the evolution of seasonal influenza

Epidemiology of influenza B in Australia: 2001‐2014 influenza seasons

Hacia un mejor control de la influenza mediante la vacunación

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