The evolutionary dynamics of repetitive DNA in eukaryotes

Charlesworth, Brian; Sniegowski, Paul D.; Stephan, Wolfgang

doi:10.1038/371215a0

Cited by 1,486 publications

(1,196 citation statements)

References 82 publications

Supporting

Mentioning

1,131

Contrasting

Unclassified

Order By: Relevance

“…In Drosophila and Arabidopsis, the rate of meiotic recombination is also reduced in transposon-rich chromosomal regions (Arabidopsis Genome Initiative, 2000;Charlesworth et al, 1994). Such sequences may correspond to paracentromeric heterochromatin and may be important in suppressing the chromosomal recombination rate around the genomic regions.…”

Section: Discussionmentioning

confidence: 99%

Physical maps and recombination frequency of six rice chromosomes

Wu¹,

Mizuno²,

et al. 2003

View full text Add to dashboard Cite

These authors contributed equally to this work. SummaryWe constructed physical maps of rice chromosomes 1, 2, and 6±9 with P1-derived arti®cial chromosome (PAC) and bacterial arti®cial chromosome (BAC) clones. These maps, with only 20 gaps, cover more than 97% of the predicted length of the six chromosomes. We submitted a total of 193 Mbp of non-overlapping sequences to public databases. We analyzed the DNA sequences of 1316 genetic markers and six centromere-speci®c repeats to facilitate characterization of chromosomal recombination frequency and of the genomic composition and structure of the centromeric regions. We found marked changes in the relative recombination rate along the length of each chromosome. Chromosomal recombination at the centromere core and surrounding regions on the six chromosomes was completely suppressed. These regions have a total physical length of about 23 Mbp, corresponding to 11.4% of the entire size of the six chromosomes. Chromosome 6 has the longest quiescent region, with about 5.6 Mbp, followed by chromosome 8, with quiescent region about half this size. Repetitive sequences accounted for at least 40% of the total genomic sequence on the partly sequenced centromeric region of chromosome 1. Rice CentO satellite DNA is arrayed in clusters and is closely associated with the presence of Centromeric Retrotransposon of Rice (CRR )-and RIce RetroElement 7 (RIRE7 )-like retroelement sequences. We also detected relatively small coldspot regions outside the centromeric region; their repetitive content and gene density were similar to those of regions with normal recombination rates. Sequence analysis of these regions suggests that either the amount or the organization patterns of repetitive sequences may play a role in the inactivation of recombination.

show abstract

Section: Discussionmentioning

confidence: 99%

Physical maps and recombination frequency of six rice chromosomes

Wu¹,

Mizuno²,

et al. 2003

View full text Add to dashboard Cite

show abstract

“…They apparently exist as parasites of the functional part of the genome, that is, the part that carries out the tasks involved in constructing and maintaining a functional organism (114). Tranposition by transposable elements is often harmful to the host organism (115). Transposable element insertions are known to be a major cause of spontaneous mutation in natural populations of Drosophila (116).…”

Section: Transposable Genetic Elementsmentioning

confidence: 99%

Intragenomic conflict and cancer

2002

View full text Add to dashboard Cite

Summary Intragenomic conflict occurs when some elements within the genome produce effects that enhance their own probability of replication or transmission at the expense of other elements within the same genome. Here it is proposed that mutations involved in intragenomic conflict are particularly likely to be co-opted by evolving lineages of cancer cells, and hence should be associated with the occurrence of cancer. We discuss several types of intragenomic conflict that are associated with various forms of cancer. ª

show abstract

“…Unequal exchange is currently the favored mechanism to explain the observed sequence homogeneity among repeats in repetitive arrays (Krüger and Vogel 1975;Smith 1976;Stephan 1989;Charlesworth et al 1994;Elder and Turner 1995). One prediction of the model is that repeats at the end of an array should exhibit the highest level of sequence divergence (Ohta 1980;Stephan 1989).…”

Section: Maintenance and Evolution Of Repetitive Arraysmentioning

confidence: 99%

“…Studies of tandem repeats have generally focused on determining the nucleotide sequence, abundance, genomic organization, and/or species distribution of the repeats (Willard 1989). Tandem repeats are routinely divided into distinct classes based on the size of the repeating sequence; such as microsatellite, minisatellite, and satellite DNA (Charlesworth et al 1994). It is the ''classic'' satellite sequences (approximately 200 bases in length) which are the focus of this investigation.…”

Section: Introductionmentioning

confidence: 99%

“…The most widely accepted mechanisms underlying maintenance of arrays of satellite DNA are unequal exchange and intrastrand exchange (Charlesworth et al 1994). Successive unequal exchanges between paralogous units of repetitive arrays on separate DNA strands prevents individual repeats from evolving independently, instead the arrays evolve in concert (Smith 1976;Ohta 1980;Stephan 1989).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evolution of Tandemly Repeated Sequences: What Happens at the End of an Array?

McAllister

Werren

1999

J Mol Evol

View full text Add to dashboard Cite

Abstract. Tandemly repeated sequences are a major component of the eukaryotic genome. Although the general characteristics of tandem repeats have been well documented, the processes involved in their origin and maintenance remain unknown. In this study, a region on the paternal sex ratio (PSR) chromosome was analyzed to investigate the mechanisms of tandem repeat evolution. The region contains a junction between a tandem array of PSR2 repeats and a copy of the retrotransposon NATE, with other dispersed repeats (putative mobile elements) on the other side of the element. Little similarity was detected between the sequence of PSR2 and the region of NATE flanking the array, indicating that the PSR2 repeat did not originate from the underlying NATE sequence. However, a short region of sequence similarity (11/15 bp) and an inverted region of sequence identity (8 bp) are present on either side of the junction. These short sequences may have facilitated nonhomologous recombination between NATE and PSR2, resulting in the formation of the junction. Adjacent to the junction, the three most terminal repeats in the PSR2 array exhibited a higher sequence divergence relative to internal repeats, which is consistent with a theoretical prediction of the unequal exchange model for tandem repeat evolution. Other NATE insertion sites were characterized which show proximity to both tandem repeats and complex DNAs containing additional dispersed repeats. An ''accretion model'' is proposed to account for this association by the accumulation of mobile elements at the ends of tandem arrays and into ''islands'' within arrays. Mobile elements inserting into arrays will tend to migrate into islands and to array ends, due to the turnover in the number of intervening repeats.

show abstract

The evolutionary dynamics of repetitive DNA in eukaryotes

Cited by 1,486 publications

References 82 publications

Physical maps and recombination frequency of six rice chromosomes

Physical maps and recombination frequency of six rice chromosomes

Intragenomic conflict and cancer

Evolution of Tandemly Repeated Sequences: What Happens at the End of an Array?

Contact Info

Product

Resources

About