The Evolutionary Significance of Lens Organ Specificity*

Manski, W.; Auerbach, Theresa P.; Halbert, Seymour P.

doi:10.1016/0002-9394(60)90351-2

Cited by 51 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The organ specific reactions of the lens tissue were confirmed by many authors for limited and random species of vertebrates (14). Previous investigations from this laboratory (16,17) have shown that anti-lens sera from all vertebrate classes gave consistently positive reactions with descendants from both extreme ends of the evolutionary scale, i. e. lamprey and human. It was thus possible to analyze by immunochemical technics (18)(19)(20), the phy logenetic relationships of lens protein molecules within the entire vertebrate subphylum, for which the fossil record has been intensive ly investigated.…”

supporting

confidence: 55%

On the Use of Antigenic Relationships among Species for the Study of Molecular Evolution

Manski¹,

Sp²,

Auerbach-Pascal³

et al. 1967

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 55%

On the Use of Antigenic Relationships among Species for the Study of Molecular Evolution

Manski¹,

Sp²,

Auerbach-Pascal³

et al. 1967

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

“…Up to now, only McAvoy [1978], working on the embryogenesis of the rat lens, observed two y-precipitin arcs by immunoelectrophoresis. Furthermore, a study by Manski et al [1960], using antihuman (cataract) lens serum, demonstrated three y-precipitin arcs against whole rat lens crystallins. These findings underline the results reported here.…”

Section: Discussionmentioning

confidence: 99%

Immunological Properties of Rat Lens Gamma-Crystallins

Vornhagen¹,

Bours²,

Rink³

1982

Ophthalmic Res

View full text Add to dashboard Cite

Rat lens γ-crystallins were separated by preparative flat bed isoelectric focusing (pH 7–11). The fractions obtained were submitted to analytical isoelectric focusing, fused rocket immunoelectrophoresis and immunodiffusion. The results demonstrate that rat lens γ-crystallins are electrophoretically and immunologically heterogenous. Evidence is given that there are two immunologically different groups. Rat γ₁-crystallin, the prominent and immunologically homogeneous part, is identical to calf lens γ-crystallin. The second group of proteins, γ₂-crystallins, is heterogeneous and shows only partial identity with γ₁ crystallin.

show abstract

“…The organ specificity of lens antigens has long been recognized (Uhlenhuth 1903). It has been suggested that they express the evolutionary history of the lens (Manski et al 1960).…”

Section: Discussionmentioning

confidence: 99%

Quantitation of Alpha Crystallin in Human Aqueous Humor by Radioimmunoassay

Sandberg¹,

Følling

Closs³

1974

Acta Ophthalmologica

View full text Add to dashboard Cite

A method for quantitation of alpha crystallin in individual samples of human aqueous humor by radioimmunoassay is described. The concentration of alpha crystallin in aqueous humor from 48 eyes with cataract and three eyes with clear lenses was at or below 0.006 pgJml. Two samples from eyes with heterochromic cataract contained 0.01 1 and 0.012 yg/ml, respectively. Alpha crystallin is probably not among those lens proteins described earlier in normal human aqueous humor.

show abstract

The Evolutionary Significance of Lens Organ Specificity*

Cited by 51 publications

References 15 publications

On the Use of Antigenic Relationships among Species for the Study of Molecular Evolution

On the Use of Antigenic Relationships among Species for the Study of Molecular Evolution

Immunological Properties of Rat Lens Gamma-Crystallins

Quantitation of Alpha Crystallin in Human Aqueous Humor by Radioimmunoassay

Contact Info

Product

Resources

About