The Evolutionary Transition of the RNA World to Obcells to Cellular-Based Life

O’Connor, Patrick B. F.

doi:10.1007/s00239-024-10171-2

J Mol Evol

2024

DOI: 10.1007/s00239-024-10171-2

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The Evolutionary Transition of the RNA World to Obcells to Cellular-Based Life

Patrick B. F. O’Connor

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2024

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Membrane bound geranylated RNAs establish a primitive peptide synthesis system

Chan,

Singer,

Carell

2024

Preprint

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The origin of an RNA-based translation system necessitates a specific interaction of certain RNAs with defined amino acids. This must have happened in a protocellular environment where these molecules were concentrated so that a connection between the encoding RNA and the amino acids could be established that allowed the formation of peptides. A model of how such a system could have evolved does not exist. Here we show that geranylated non-canonical nucleotides that are potential fossils in an early RNA world, allow RNA to anchor to lipid membranes. This creates RNA-geranylating lipids on which a primitive peptide synthesis can then operate with rudimentary chemoselectivity. The system creates a protocellular model of how RNAs and amino acids could have been mutually selected based on their physicochemical properties.

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Membrane bound geranylated RNAs establish a primitive peptide synthesis system

Chan,

Singer,

Carell

2024

Preprint

View full text Add to dashboard Cite

show abstract

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The Evolutionary Transition of the RNA World to Obcells to Cellular-Based Life

Cited by 1 publication

References 74 publications

Membrane bound geranylated RNAs establish a primitive peptide synthesis system

Membrane bound geranylated RNAs establish a primitive peptide synthesis system

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