The Evolvement of OCT and OCT-A in Identifying Multiple Sclerosis Biomarkers

Donica, Vlad Constantin; Alexa, Anisia Iuliana; Pavel, Irina Andreea; Danielescu, Ciprian; Ciapă, Manuela Andreea; Donica, Alexandra Lori; Bogdănici, Camelia Margareta

doi:10.3390/biomedicines11113031

Biomedicines

2023

DOI: 10.3390/biomedicines11113031

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The Evolvement of OCT and OCT-A in Identifying Multiple Sclerosis Biomarkers

Vlad Constantin Donica,

Anisia Iuliana Alexa,

Irina Andreea Pavel

et al.

Abstract: The prevalence of multiple sclerosis (MS) has been increasing among young people in developing countries over the last years. With the continuous development of new technology, the diagnosis and follow-up of these patients has received new parameters that physicians may use in their practice. This paper reviews the main biomarkers identified through Optical Coherence Tomography Angiography (OCT-A) involved in the development and progression of MS and investigates the role it may have in detecting changes to th… Show more

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2024

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Cited by 2 publications

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Advancements in Neurodegenerative Diseases: Pathogenesis and Novel Neurorestorative Interventions

Gao,

Jing,

et al. 2024

Journal of Neurorestoratology

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Advancements in Neurodegenerative Diseases: Pathogenesis and Novel Neurorestorative Interventions

Gao,

Jing,

et al. 2024

Journal of Neurorestoratology

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Variabilities in Retinal Hemodynamics Across the Menstrual Cycle in Healthy Women Identified Using Optical Coherence Tomography Angiography

Donica,

Pavel

et al. 2024

Life

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Background: Numerous conditions, both physiological and pathological, can influence changes in the retinal vascular architecture. In order to be able to highlight pathological aspects of systemic diseases with ocular activity, it is necessary to understand how physiological fluctuations can influence circulation at the retinal level. The present study attempts to evaluate retinal and choroidal vascular and structural changes in healthy female subjects over the course of a menstrual cycle using OCT-A. Methods: We analyzed 22 eyes from healthy reproductive women with a regular menstrual cycle. We performed five OCT-A scans of the subjects every 7–8 days over the course of a month starting from the first day of the menstrual cycle and ending with the first day of the next cycle, measuring perfusion density in the superficial and deep vascular plexuses, choroidal thickness, and FAZ perimeter. Results: There are physiological variations in retinal hemodynamics that can be identified using OCT-A, choroidal thickness having statistically significant increased values in the parafoveal nasal sector during the ovulatory phase (289.18 µm) compared to the early follicular phase (281.9 µm), and the subfoveal sector during the ovulatory phase (319.04 µm) compared to the early follicular phase (308.27 µm). Conclusions: These findings along with abnormally small FAZ perimeters indicate that the menstrual cycle phase should be considered whenever interpreting OCT-A results. Further studies that include larger cohorts, control groups, and hormone serum levels are necessary to confirm and correlate retinal vascular alterations and the phase of the menstrual cycle using OCT-A.

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The Evolvement of OCT and OCT-A in Identifying Multiple Sclerosis Biomarkers

Cited by 2 publications

References 84 publications

Advancements in Neurodegenerative Diseases: Pathogenesis and Novel Neurorestorative Interventions

Advancements in Neurodegenerative Diseases: Pathogenesis and Novel Neurorestorative Interventions

Variabilities in Retinal Hemodynamics Across the Menstrual Cycle in Healthy Women Identified Using Optical Coherence Tomography Angiography

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