The Evolving Role of Diffusion Magnetic Resonance Imaging in Movement Disorders

Hess, Christopher W.; Ofori, Edward; Akbar, Umer; Okun, Michael S.; Vaillancourt, David E.

doi:10.1007/s11910-013-0400-1

Cited by 13 publications

(7 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There has been wide variability in the methodology used to analyze diffusion MRI data for PD and other movement disorders (Hess et al, 2013). Some studies have used an ROI approach on individual subject data.…”

Section: Discussionmentioning

confidence: 99%

Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study

Ofori

Pasternak

Planetta

et al. 2015

Neurobiology of Aging

Self Cite

143

158

View full text Add to dashboard Cite

Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra of Parkinson’s disease. It is the case, however, that partial volume effects from free-water can bias diffusion measurements. The bi-tensor diffusion model was introduced to quantify the contribution of free-water and eliminates its bias on estimations of tissue microstructure. Here, we test the hypothesis that free-water is elevated in the substantia nigra for Parkinson’s disease compared with controls. This hypothesis was tested between large cohorts of Parkinson’s disease and control participants in a single-site study, and validated against a multi-site study using multiple scanners. The fractional volume of free-water was increased in the posterior region of the substantia nigra in Parkinson’s disease compared with controls in both the single-site and multi-site studies. We did not observe changes in either cohort for free-water corrected fractional anisotropy or free-water corrected mean diffusivity. Our findings provide new evidence that the free-water index reflects alteration of the substantia nigra in Parkinson’s disease, and this was evidenced across both single-site and multi-site cohorts.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study

Ofori

Pasternak

Planetta

et al. 2015

Neurobiology of Aging

Self Cite

143

158

View full text Add to dashboard Cite

show abstract

“…Diffusion tensor imaging (DTI) is a MRI technique that can reveal the microstructural integrity of brain tissues 5 6 7 . The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) are used to quantify the magnitude and directionality of water molecular diffusion, respectively.…”

mentioning

confidence: 99%

Combined Diffusion Tensor Imaging and Arterial Spin Labeling as Markers of Early Parkinson’s disease

Wei

Yan

Chen

et al. 2016

Sci Rep

View full text Add to dashboard Cite

This study aimed to identify a PD-specific MRI pattern using combined diffusion tensor imaging (DTI) and arterial spin labeling (ASL) to discriminate patients with early PD from healthy subjects and evaluate disease status. Twenty-one early and 22 mid-late PD patients, and 22 healthy, age/gender-matched controls underwent 3-T MRI with apparent diffusion coefficient (ADC), fractional anisotropy (FA), fiber number (FN) and cerebral blood flow (CBF) measurements. We found that compared with healthy subjects, there was a profound reduction in FN passing through the SN in PD. FA in the SN and CBF in the caudate nucleus were inversely correlated with motor dysfunction. A negative correlation was observed between FA in the hippocampus (Hip) and the NMSS-Mood score, whereas CBF in the Hip and the prefrontal cortex(PFC) correlated with declined cognition. Stratified five-fold cross-validation identified FA in the SN(FA-SNAv), CBF in the PFC(CBF-PFCAv) and FA in the parietal white matter(FA-PWMAv), and the combination of these measurements offered relatively high accuracy (AUC 0.975, 90% sensitivity and 100% specificity) in distinguishing those with early PD from healthy subjects. We demonstrate that the decreased FNs through SN in combination with changes in FA-SNAv, CBF-PFCAv and FA-PWMAv values might serve as potential markers of early-stage PD.

show abstract

“…These a priori ROIs were (1) putamen and (2) cerebellar cortex. The other ROIs were components of sensorimotor circuitry commonly evaluated in movement disorder studies [e.g., (Berardelli A et al 1998; Defazio G et al 2007; Breakefield XO et al 2008; Niethammer M et al 2011; Poston KL and D Eidelberg 2012; Hess CW et al 2013; Lehericy S et al 2013), including (3) globus pallidus, (4) caudate, (5) thalamus, (6) primary motor cortex overlying hand representation (1°Mh), (7) areas 3a and (8) 3b of primary somatosensory cortex overlying hand representation, (9) supplementary motor area, (10) dorsal premotor cortex, (11) ventral premotor cortex, (12) area 1 of somatosensory cortex, and (13) area 2 of somatosensory cortex. In addition, for post hoc analyses of motor cortex neck representations we evaluated primary motor cortex (14) dorsal (1°Md), and (15) ventral (1°Mv) to the hand representation (see (Thompson ML et al 1997) for evidence of two neck representations in motor cortex, including the less frequently discussed dorsal region).…”

Section: Methodsmentioning

confidence: 99%

Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia

Kuster

Levenstein

Waugh

et al. 2023

Preprint

View full text Add to dashboard Cite

We previously observed sustained fMRI BOLD signal in the basal ganglia in focal hand dystonia patients after a repetitive finger tapping task. Since this was observed in a task-specific dystonia, for which excessive task repetition may play a role in pathogenesis, in the current study we asked if this effect would be observed in a focal dystonia (cervical dystonia [CD]) that is not considered task-specific or thought to result from overuse. We evaluated fMRI BOLD signal time courses before, during, and after the finger tapping task in CD patients. We observed patient/control differences in post-tapping BOLD signal in left putamen and left cerebellum during the non-dominant (left) hand tapping condition, reflecting abnormally sustained BOLD signal in CD. BOLD signals in left putamen and cerebellum were also abnormally elevated in CD during tapping itself and escalated as tapping was repeated. There were no cerebellar differences in the previously studied FHD cohort, either during or after tapping. We conclude that some elements of pathogenesis and/or pathophysiology associated with motor task execution/repetition may not be limited to task-specific dystonias, but there may be regional differences in these effects across dystonias, associated with different types of motor control programs.

show abstract

The Evolving Role of Diffusion Magnetic Resonance Imaging in Movement Disorders

Cited by 13 publications

References 103 publications

Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study

Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study

Combined Diffusion Tensor Imaging and Arterial Spin Labeling as Markers of Early Parkinson’s disease

Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia

Contact Info

Product

Resources

About