The Evolving Role of Induced Pluripotent Stem Cells and Cerebral Organoids in Treating and Modeling Neurosurgical Diseases

Jovanovich, Nicolina; Habib, Ahmed; Kodavali, Chowdari; Edwards, Lincoln; Amankulor, Nduka; Zinn, Pascal O.

doi:10.1016/j.wneu.2021.08.081

Cited by 5 publications

(7 citation statements)

References 73 publications

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“…Brain tumor organoids such as GLICO use patient-derived tumor cells to retain the heterogeneity, histopathology, and genetic makeup of tumor cells, but they still lack a native tumor microenvironment [134]. These models are especially useful to investigate invasion.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…An appealing alternative to culture organoids might be 3D bioprinted organoids containing all the components of a brain tumor and its microenvironment and maintaining proper cell-cell and cell-matrix interaction. However, the overwhelming complexity of brain tumors and high cost has restricted their use [23,134].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Primary tumor-derived organoids are the most relevant mimetics in this direction, as they retain heterogeneous cancer stem cell composition to ensure their simultaneous growth and desired cellular hierarchy [137,138]. Co-clinical trials are increasingly supporting the similarity of cancer drug responses in biobanked organoids and patients [134]. These models hold promise to become excellent systems for semi-high-throughput drug screening in the foreseeable future [23,24].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Modeling Human Brain Tumors and the Microenvironment Using Induced Pluripotent Stem Cells

Khamis

Sarker

Xue

et al. 2023

Cancers

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Brain cancer is a group of diverse and rapidly growing malignancies that originate in the central nervous system (CNS) and have a poor prognosis. The complexity of brain structure and function makes brain cancer modeling extremely difficult, limiting pathological studies and therapeutic developments. Advancements in human pluripotent stem cell technology have opened a window of opportunity for brain cancer modeling, providing a wealth of customizable methods to simulate the disease in vitro. This is achieved with the advent of genome editing and genetic engineering technologies that can simulate germline and somatic mutations found in human brain tumors. This review investigates induced pluripotent stem cell (iPSC)-based approaches to model human brain cancer. The applications of iPSCs as renewable sources of individual brain cell types, brain organoids, blood–brain barrier (BBB), and brain tumor models are discussed. The brain tumor models reviewed are glioblastoma and medulloblastoma. The iPSC-derived isogenic cells and three-dimensional (3D) brain cancer organoids combined with patient-derived xenografts will enhance future compound screening and drug development for these deadly human brain cancers.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Modeling Human Brain Tumors and the Microenvironment Using Induced Pluripotent Stem Cells

Khamis

Sarker

Xue

et al. 2023

Cancers

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“…Several neurological diseases have been studied using iPSC technology as well ( Jovanovich et al, 2021 ). One of them is amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease affecting motor neurons (MNs).…”

mentioning

confidence: 99%

Editorial: Advances in iPSC technology for disease modeling and therapeutic applications

Wattanapanitch,

Chailangkarn,

Miranda

et al. 2023

Front. Cell Dev. Biol.

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“…Patients' bone marrow or peripheral blood supply these stem cells Pre-transplantation cell extraction is required. 8 This study examines cell preservation and return. The results show that cells may be stored and repositioned.…”

mentioning

confidence: 99%

Leveraging electronic health records and stem cell transplants: a review

Teja,

Gundimeda,

Kolipakula

et al. 2023

Int J Sci Rep

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Biomedical informatics is a burgeoning multidisciplinary field that seeks to optimize the utilization of biomedical data, information, and knowledge for the purposes of scientific research, inquiry, problem-solving, and decision-making, all with the overarching objective of enhancing human health and well-being. Information, informatics, and its applications are used in organ transplantations, such as stem cell transplantation programs, and in programs that directly change disorders. So, many hospitals can maintain EMRs (Electronic medical records), but few are supporting C programs. So, using informatics, we introduced software and programs to run these SCT applications in a very short period of time without any effect.

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The Evolving Role of Induced Pluripotent Stem Cells and Cerebral Organoids in Treating and Modeling Neurosurgical Diseases

Cited by 5 publications

References 73 publications

Modeling Human Brain Tumors and the Microenvironment Using Induced Pluripotent Stem Cells

Modeling Human Brain Tumors and the Microenvironment Using Induced Pluripotent Stem Cells

Editorial: Advances in iPSC technology for disease modeling and therapeutic applications

Leveraging electronic health records and stem cell transplants: a review

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