The evolving role of lymphatics in cancer metastasis

Farnsworth, Rae H.; Achen, Marc G.; Stacker, Steven A.

doi:10.1016/j.coi.2018.04.008

Cited by 84 publications

(110 citation statements)

References 61 publications

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“…First of all, multifunctional materials will be further developed, because the establishment of a successful immune response against metastasis usually requires simultaneous adjustment of a network of factors. [65,167] CCR7 intervention using CCR7 trap protein has been proved effective to inhibit lymphatic metastasis, [166] which may also be potentially prime immune cells in DLNs. Third, the development of nanomedicine that can inhibit the formation of premetastatic niche is necessary, especially for patients with nonresectable tumors.…”

Section: Discussionmentioning

confidence: 99%

“…[60][61][62] After dissemination, the survival of CTCs in blood and lymphatic vessel is another critical step before establishing a [1] while the survival and migration of CTC in the lymphatic vessel heavily relies on CC chemokine receptor type 7 (CCR7)/CC motif chemokine ligand 21 (CCL21) mediated crosstalk and immunosuppressive environment in the lymphatic vessels. [63][64][65] When the DTCs reach premetastatic niches, they will further recruit progenitor cells and immune cells such as macrophages, neutrophils, and MDSCs, all of which facilitate extravasation of DTCs. [1] After extravasation, the DTCs continue recruiting monocytes, which differentiate into metastasis-associated macrophages (MAMs) that are important for survival of DTCs.…”

Section: Immune Cells In Metastatic Cascadementioning

confidence: 99%

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Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis

et al. 2019

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Metastasis is the leading cause of cancer‐associated death, with poor prognosis even after extensive treatment. The dormancy of metastatic cancer cells during dissemination or after colony formation is one major reason for treatment failure, as most drugs target cells of active proliferation. Immunotherapy has shown great potential in cancer therapy because the activity of effector cells is less affected by the metabolic status of cancer cells. In addition, metastatic cells out of immunosuppressive tumor microenvironment (TME) are more susceptible to immune clearance, although these cells can achieve immune surveillance evasion via strategies such as platelet and macrophage recruitment. Since nanomaterials themselves or their carried drugs have the capability to modulate the immune system, a great amount of focus has been placed on nanomedicine strategies that leverage immune cells participating the metastatic cascade. These nanomedicines successfully inhibit the tumor metastasis and prolong the survival of model animals. Immune cells that are involved in the metastasis cascade are first summarized and then recent and inspiring strategies and nanomaterials in this growing field are highlighted.

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Section: Discussionmentioning

confidence: 99%

Section: Immune Cells In Metastatic Cascadementioning

confidence: 99%

Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis

et al. 2019

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“…Aberrant lymphangiogenesis and restructuring of lymphatic networks have been shown to significantly enhance metastasis to both regional lymph nodes and distal organs 155 through the secretion of various factors such as vascular endothelial growth factor A/D (VEGF-A/D) 156 , VEGF-C 150, 157 , interleukin 1 beta (IL-1β) 158 , fibroblast growth factor (FGF) 159 , ECM components such as periostin 160 , or even chronic stress activation of the sympathetic nervous system 161 .…”

Section: Going With the Flow: Intravasation Into Blood And Lymphaticsmentioning

confidence: 99%

Recent advances in understanding the complexities of metastasis

et al. 2018

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Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-autonomous program but as a multifaceted and complex series of events, which is influenced by the intrinsic cellular mutational burden of cancer cells and the numerous bidirectional interactions between malignant and non-malignant cells and fine-tuned by the various extrinsic cues of the extracellular matrix. In cancer biology, metastasis as a process is one of the most technically challenging aspects of cancer biology to study. As a result, new platforms and technologies are continually being developed to better understand this process. In this review, we discuss some of the recent advances in metastasis and how the information gleaned is re-shaping our understanding of metastatic dissemination.

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“…It is likely that the explanation is complex. For example, SLL appears to be highly dependent on the nature of the local microenvironment for its survival and neoplastic lymphoid cells alter local cytokine signaling, reducing the adhesion of breast cancer cells to endothelial cells, which may serve to reduce the metastatic colonization of the node around the lymphoma. Interestingly, a converse mechanism is suggested in this case—the metastatic carcinoma protected normal lymph node architecture despite widespread lymphomatous colonization of all the other local nodes.…”

Section: Introductionmentioning

confidence: 99%

Synchronous small lymphocytic lymphoma and metastatic breast carcinoma in axillary lymph nodes: Preservation of follicular architecture only in the portions of affected lymph nodes involved by metastatic carcinoma

Haynes

Rose

2019

Breast J

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We present a case of metastatic ductal carcinoma of breast with the incidental discovery of small lymphocytic lymphoma (SLL) in regional axillary nodes. The co‐occurence of metastatic carcinoma and low‐grade lymphoma in lymph nodes is rare but well recognized. However, in this case, in the lymph nodes in which sizeable metastatic carcinoma deposits were present, the follicular structures between the sinusoidal carcinomatous infiltrates were preserved, whereas the uninvolved portions of the nodes were overrun by SLL. This is the first description of this phenomenon. We suggest that further cases displaying this previously unpublished pattern are collated in order that we may begin to investigate the underlying etiological mediators.

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The evolving role of lymphatics in cancer metastasis

Cited by 84 publications

References 61 publications

Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis

Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis

Recent advances in understanding the complexities of metastasis

Synchronous small lymphocytic lymphoma and metastatic breast carcinoma in axillary lymph nodes: Preservation of follicular architecture only in the portions of affected lymph nodes involved by metastatic carcinoma

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