The evolving role of radiation therapy as treatment for liver metastases

Alrabiah, Khalid; Liao, Guixiang; Shen, Qi; Chiang, Chi Leung; Dawson, Laura A.

doi:10.1016/j.jncc.2022.06.004

Cited by 7 publications

(1 citation statement)

References 50 publications

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“…Various motion management mechanisms can be used, such as fiducial markers, abdominal compression, breath hold techniques, gating, and tumor tracking [83,86,87]. Imaging studies for motion measurement and evaluation include fluoroscopy, 4D CT, 4D cone-beam computer tomography scans, 2D cine MR, and 4D MR imaging [1,[88][89][90]. Several studies have demonstrated that the use of advanced motion management techniques in liver SBRT is associated with improved LC of liver metastases [12,91].…”

Section: Advanced Organ Motion Managementmentioning

confidence: 99%

Local Control Following Stereotactic Body Radiation Therapy for Liver Oligometastases: Lessons from a Quarter Century

Mheid,

Allen,

et al. 2023

Current Oncology

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The utilization of stereotactic body radiation therapy for the treatment of liver metastasis has been widely studied and has demonstrated favorable local control outcomes. However, several predictive factors play a crucial role in the efficacy of stereotactic body radiation therapy, such as the number and size (volume) of metastatic liver lesions, the primary tumor site (histology), molecular biomarkers (e.g., KRAS and TP53 mutation), the use of systemic therapy prior to SBRT, the radiation dose, and the use of advanced technology and organ motion management during SBRT. These prognostic factors need to be considered when clinical trials are designed to evaluate the efficacy of SBRT for liver metastases.

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