The examination of protective effects of gallic acid against damage of oxidative stress during induced-experimental renal ischemia-reperfusion in experiment

Abstract

Abstract:Aim: In this study, probable effects of gallic acid were investigated in experimentally induced renal I/R injury in rats. Material and methods: For this purpose, each group consisted of 7 Spraque dawley male albino rats. Groups were defi ned as follows; Group I: control group; Group II: I/R group; Group III, IV and V: I/R+Gallic acid (50, 100 and 200 mg.kg -1 respectively-i.p.). Left kidney was removed by nephrectomy except for Group I. I/R was induced in the other kidney. Gallic acid was given 15 mins before ischemia induction. SOD, CAT and Gpx activities were determined by electrophoresis. MDA, MPO levels were determined spectrophotometrically. Histopathological investigations were also performed in kidney tissues. BUN and Creatinine levels in serum were determined. Results: BUN, Creatinine and MDA levels were statistically signifi cant but MPO level was not statistically signifi cantly increased in Group II. For SOD, CAT, Gpx activities in Group II, an increase was determined with respect to Group I. Histopathological investigations revealed widespread hyperemia in glomerulus, expansion of the structure between tubules and cell disruptions in Group II. In Group V (200 mg.kg -1 gallic acid), in terms of biochemical parameters, in spite of the signifi cant decrease in BUN, Creatinine and MDA levels; a decrease was determined in SOD, CAT and Gpx isoenzyme activities. Group V showed histologically that I/R injury had been prevented to a greater extent and appearances were close to the control. Conclusion: As a result, in terms of our study, evaluations regarding kidney functions and histopathology have shown that gallic acid has protective effects in renal I/R injury (Tab. 2, Fig. 5, Ref. 36). Text in PDF www.elis.sk.

Gallic acid protects rat liver mitochondria ex vivo from bisphenol A induced oxidative stress mediated damages

“…It has been established that GA has the ability in lowering the systolic blood pressure in rats with essential hypertension, and in providing the protection against NOX2-induced oxidative stress response [12]. Earlier study reveals that GA can provide protection against renal oxidative stress by reducing peroxidation intensity [13]. Besides, high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress also can be protected by GA as studied in rats [14].…”

The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats

“…In the work of Senturk and Yıldız (2018); in a renal I/R model, groups treated with antioxidant substance demonstrated a dosedependent decrease in CAT and SOD amounts. Canbek et al (2014) in a study conducted, revealed that the application of antioxidant substances in rats with renal I/R damage (45 min/6h) caused the band densities of SOD and CAT to be decreased. Many similar manuscripts have been found, for example (Bayramoglu et al, 2011), the results of which are in parallel with our study.…”

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