The Exchangeable Potassium Content in Disease States 12

Aikawa, Jerry K.; Felts, John H.; Tyor, Malcolm P.; Harrell, George T.; Rhoades, Eloise L.

doi:10.1172/jci102658

Cited by 18 publications

(6 citation statements)

References 6 publications

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“…4,6 Preliminary studies in this laboratory confirmed the observations of Corsa and his associates5 that the specific activity of K42 in the urine reaches an equilibrium in both diseased and normal subjects within 18 hours. The mean difference in specific activity among the 3 spot specimens, when expressed as percentage of the mean Ke, was 4.57 2.76 per cent.…”

supporting

confidence: 80%

“…This difficulty can be overcome by the use of the isotope-dilution technic -a technic that has previously been applied to studies on the pathophysiology of other disease states. 4 The purpose of the present study was to determine MATERIAL AND METHODS Subjects. Eleven patients with advanced congestive failure, 8 men and 3 women, were studied.…”

mentioning

confidence: 99%

“…Isotopic potassium (K42) * was prepared for injection in the manner previously described. 4 Measurement of Radioactivity. The activity of the urine specimens was determined with a well-type scintillation counter and a scaling circuit.…”

mentioning

confidence: 99%

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Exchangeable Potassium Content of the Body in Congestive Failure

1956

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With the technical assistance of Aaron J. BlumbergThe increase in body weight in congestive heart failure is generally attributed to the retention of sodium and water in the extracellular compartment. Important changes also occur in the intracellular space, particularly in the metabolism of potassium. The isotope-dilution technic permits more precise determination of the exchangeable potassium content of the body in congestive failure before and during diuresis. The results of 27 such determinations in 11 patients with congestive heart failure are correlated with the clinical status of the patient and the serum concentration.IT HAS generally been assumed that an increase in body weight that occurs during congestive heart failure is due to retention of sodium and water in the extracellular compartment. Recent studies, however, have suggested that changes also occur in the intracellular phase, and in the metabolism of potassium as well as sodium.'-3 The external balance method, which has been used in most previous studies of this problem, does not permit the direct measurement in vivo of the body's potassium content. This difficulty can be overcome by the use of the isotope-dilution technic -a technic that has previously been applied to studies on the pathophysiology of other disease states.4The purpose of the present study was to determine, by use of the in vivo isotope-dilution technic, changes in the exchangeable potassium content of the body during the therapy of congestive failure. Serial determinations of the exchangeable potassium content were made in hospitalized patients, and the changes in this value were correlated with the alterations in serum electrolytes, body weight, and the clinical response.

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confidence: 80%

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Exchangeable Potassium Content of the Body in Congestive Failure

1956

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“…Body potassium was no lower in the patients with edema than in the hospitalized "controls" when the diluting effect of edema water was eliminated. The values for Ke/body weight in these patients are in accord with those published previously (11,15,16,20,22,23). Body potassium appeared to be abnormally low in all patient groups.…”

Section: Discussionsupporting

confidence: 90%

“…Similar studies in a variety of disease states have shown changes in body composition characterized by decreases in body fat, cell mass, and body potassium, and increases in body sodium and water, when these values are expressed on a body weight basis (11)(12)(13)(14)(15)(16). While this pattern of change in composition is apparent in chronically ill or acutely stressed patients who are free of edema, it is particularly pronounced in edematous subjects (13,14,(16)(17)(18).…”

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confidence: 76%