The excitatory thalamo‐“cortical” projection within the song control system of zebra finches is formed by calbindin‐expressing neurons

Pinaud, Raphael; Saldanha, Colin J.; Wynne, Ryan D.; Lovell, Peter V.; Mello, Claudio V.

doi:10.1002/cne.21457

Cited by 19 publications

(15 citation statements)

References 92 publications

(150 reference statements)

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“…The border between CORE and SHELL regions of LMAN can be distinguished based on the density of magnocellular somata (Figure f), and the outer borders of SHELL can be distinguished from surrounding regions based on the intensity of neuropil staining. Some brains were stained immunohistochemically for calbindin, which specifically labels thalamic axons projecting to LMAN (Figure d, lower panel) (Achiro & Bottjer, ; Pinaud et al, ). Calbindin expression defined the outer borders of LMAN‐SHELL precisely, and revealed that even small injections into dNCL SHELL produced retrograde label within regions immediately surrounding SHELL ( n = 4).…”

Section: Resultsmentioning

confidence: 99%

“…In seven brains, the alternate series was stained for calbindin using established immuno‐histochemical procedures. Calbindin expression specifically labels thalamic axons terminating in LMAN (Achiro & Bottjer, ; Pinaud, Saldanha, Wynne, Lovell, & Mello, ) and delineates the borders of LMAN‐SHELL precisely (Figure d, lower panel). Briefly, birds were perfused with 4% paraformaldehyde (PFA) containing 0.4% glutaraldehyde, and brains were post‐fixed in 4% PFA for 30–50 hr before being immersed in 30% sucrose.…”

Section: Methodsmentioning

confidence: 99%

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Cortical inter‐hemispheric circuits for multimodal vocal learning in songbirds

Paterson

Bottjer

2017

J of Comparative Neurology

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Vocal learning in songbirds and humans is strongly influenced by social interactions based on sensory inputs from several modalities. Songbird vocal learning is mediated by cortico-basal ganglia circuits that include the SHELL region of lateral magnocellular nucleus of the anterior nidopallium (LMAN), but little is known concerning neural pathways that could integrate multimodal sensory information with SHELL circuitry. In addition, cortical pathways that mediate the precise coordination between hemispheres required for song production have been little studied. In order to identify candidate mechanisms for multimodal sensory integration and bilateral coordination for vocal learning in zebra finches, we investigated the anatomical organization of two regions that receive input from SHELL: the dorsal caudolateral nidopallium (dNCL ) and a region within the ventral arcopallium (Av). Anterograde and retrograde tracing experiments revealed a topographically organized inter-hemispheric circuit: SHELL and dNCL , as well as adjacent nidopallial areas, send axonal projections to ipsilateral Av; Av in turn projects to contralateral SHELL, dNCL , and regions of nidopallium adjacent to each. Av on each side also projects directly to contralateral Av. dNCL and Av each integrate inputs from ipsilateral SHELL with inputs from sensory regions in surrounding nidopallium, suggesting that they function to integrate multimodal sensory information with song-related responses within LMAN-SHELL during vocal learning. Av projections share this integrated information from the ipsilateral hemisphere with contralateral sensory and song-learning regions. Our results suggest that the inter-hemispheric pathway through Av may function to integrate multimodal sensory feedback with vocal-learning circuitry and coordinate bilateral vocal behavior.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Cortical inter‐hemispheric circuits for multimodal vocal learning in songbirds

Paterson

Bottjer

2017

J of Comparative Neurology

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“…Johnson et al 1995 [43] and Bottjer et al [92] noted that DLM had a dorsolateral part that projects to LMAN, and a ventromedial part that projects to the nidopallium around LMAN. Based on calbindin expression and other evidence, Pinaud et al [93] proposed calling these areas the DLM core and shell, respectively, and argued that the surrounding area is really a larger DLM structure. We believe that all of these different designations (aDLM, DLM core, and dorsolateral DLM) refer to the same area that is connected to the song system, which we prefer to call aDLM, as an anterior specialized part of DLM.…”

Section: Discussionmentioning

confidence: 99%

Specialized Motor-Driven dusp1 Expression in the Song Systems of Multiple Lineages of Vocal Learning Birds

et al. 2012

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Mechanisms for the evolution of convergent behavioral traits are largely unknown. Vocal learning is one such trait that evolved multiple times and is necessary in humans for the acquisition of spoken language. Among birds, vocal learning is evolved in songbirds, parrots, and hummingbirds. Each time similar forebrain song nuclei specialized for vocal learning and production have evolved. This finding led to the hypothesis that the behavioral and neuroanatomical convergences for vocal learning could be associated with molecular convergence. We previously found that the neural activity-induced gene dual specificity phosphatase 1 (dusp1) was up-regulated in non-vocal circuits, specifically in sensory-input neurons of the thalamus and telencephalon; however, dusp1 was not up-regulated in higher order sensory neurons or motor circuits. Here we show that song motor nuclei are an exception to this pattern. The song nuclei of species from all known vocal learning avian lineages showed motor-driven up-regulation of dusp1 expression induced by singing. There was no detectable motor-driven dusp1 expression throughout the rest of the forebrain after non-vocal motor performance. This pattern contrasts with expression of the commonly studied activity-induced gene egr1, which shows motor-driven expression in song nuclei induced by singing, but also motor-driven expression in adjacent brain regions after non-vocal motor behaviors. In the vocal non-learning avian species, we found no detectable vocalizing-driven dusp1 expression in the forebrain. These findings suggest that independent evolutions of neural systems for vocal learning were accompanied by selection for specialized motor-driven expression of the dusp1 gene in those circuits. This specialized expression of dusp1 could potentially lead to differential regulation of dusp1-modulated molecular cascades in vocal learning circuits.

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“…Clones were originally obtained by screening a λgt10 cDNA library, through polymerase chain reaction (PCR) cloning or derived from the ESTIMA clone collection, which is publicly available at http://titan.biotec.uiuc.edu/cgi-bin/ESTWebsite/estima_start?seqSet=songbird (Mello et al. , 1992; Pinaud et al. , 2004, 2007; Replogle et al.…”

Section: Methodsmentioning

confidence: 99%

Neurochemical organization and experience‐dependent activation of estrogen‐associated circuits in the songbird auditory forebrain

Jeong

Burrows

Tremere

et al. 2011

Eur J of Neuroscience

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The classic steroid hormone estradiol is rapidly produced by central auditory neurons in the songbird brain and instantaneously modulates auditory coding to enhance the neural and behavioral discrimination of acoustic signals. Although these recent advances highlight novel roles for estradiol in the regulation of central auditory processing, current knowledge on the functional and neurochemical organization of estrogen-associated circuits, as well as the impact of sensory experience in these auditory forebrain networks, remains very limited. Here we show that both estrogen-producing and -sensitive neurons are highly expressed in the caudomedial nidopallium (NCM), the zebra finch analog of the mammalian auditory association cortex, but not other auditory forebrain areas. We further demonstrate that auditory experience primarily engages estrogen-producing, and to a lesser extent, estrogen-responsive neurons in NCM, that these neuronal populations moderately overlap, and that acute episodes of sensory experience do not quantitatively affect these circuits. Finally, we show that whereas estrogen-producing cells are neurochemically heterogenous, estrogen-sensitive neurons are primarily glutamatergic. These findings reveal the neurochemical and functional organization of estrogen-associated circuits in the auditory forebrain, demonstrate their activation and stability in response to sensory experience in behaving animals, and highlight estrogenic circuits as fundamental components of central networks supporting sensory processing.

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The excitatory thalamo‐“cortical” projection within the song control system of zebra finches is formed by calbindin‐expressing neurons

Cited by 19 publications

References 92 publications

Cortical inter‐hemispheric circuits for multimodal vocal learning in songbirds

Cortical inter‐hemispheric circuits for multimodal vocal learning in songbirds

Specialized Motor-Driven dusp1 Expression in the Song Systems of Multiple Lineages of Vocal Learning Birds

Neurochemical organization and experience‐dependent activation of estrogen‐associated circuits in the songbird auditory forebrain

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