The Excretion of Penicillin in the Spinal Fluid in Meningitis

Mechanisms of Drug Absorption and Excretion Passage of Drugs in and out of the Central Nervous System

“…No changes in bromide transfer were noted in other types of lympho cytic meningitis (96). Similar qualitative observations have been made for penicillin (98), and oxytetracycline (99).…”

A Survey of Recent Developments in the Treatment of Pneumococcal Meningitis

“…Despite the contention of Rosenberg and Sylvester (1944) that 24-40,000 units of penicillin administered intramuscularly or intravenously were sufficient to produce reasonable penetration into the C.S.F. in meningitic cases, the consensus of opinion has been that intrathecal therapy is necessary in pneumococcal meningitis (Rammelkamp and Keefer, 1943;Smith et al, 1944,1946;Anderson, 1945;Smith, 1945;Ross and Burke, 1946).…”

Diagnosis and Management of Bacterial Meningitis

“…Although there have been reports of trials of oral therapy in meningitis (Schoenbach et al, 1952), the intravenous or intramuscular routes are to be preferred, since absorption is assured and high blood levels can bl) Rosenberg and Sylvester (1944) Brumfitt et aI. Boger and Gavin (1961); Manden and Hyde (1962); Wynne and Cooke (1966) 1:1.…”