The exercise pressor reflex: An update

Teixeira, André L.; Vianna, Lauro C.

doi:10.1007/s10286-022-00872-3

Cited by 27 publications

(24 citation statements)

References 204 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5A and B). Given that HC067047 attenuated the response to mechanical stimulation in both DRG neurons and muscle group IV afferent fibres, the findings suggest that mechanical responsiveness of DRG neurons innervating skeletal (Jankowski et al, 2013;Kaufman et al, 1983;Teixeira & Vianna, 2022). That being said, in the current study we measured group IV instead of group III fibres to investigate the role of TRPV4 in mechanotransduction in rat skeletal muscle afferents.…”

Section: Controlmentioning

confidence: 89%

“…It is well known that group III fibres are predominately more mechanically sensitive and group IV afferent fibres are generally more metabolically sensitive (Jankowski et al., 2013; Kaufman et al., 1983; Teixeira & Vianna, 2022). That being said, in the current study we measured group IV instead of group III fibres to investigate the role of TRPV4 in mechanotransduction in rat skeletal muscle afferents.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents

Fukazawa

Hori

Hotta

et al. 2023

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

Section: Controlmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents

Fukazawa

Hori

Hotta

et al. 2023

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Central command is generally defined as descending neural signals from the higher brain centers that simultaneously increase motor efferent drive and autonomic neural outflow (17). The term exercise pressor reflex is defined as a neural mechanism mediated by afferent fibers emanating from skeletal muscle, contributing to the cardiovascular and respiratory changes to exercise (18,19,26). These afferents include thinly myelinated group III fibers that are predominantly activated by mechanical distortion within the contracting and/or stretching muscles (i.e., muscle mechanoreflex) and unmyelinated group IV fibers that are predominantly stimulated by metabolic byproducts of muscle contraction (i.e., muscle metaboreflex) (20).…”

Section: Autonomic Control Of the Circulation During Exercise In Healthmentioning

confidence: 99%

“…, arterial and cardiopulmonary baroreflexes) (21,22) are involved in the neural control of the circulation during exercise. The role of each mechanism and the complexity of their interaction during exercise have been reviewed in detail elsewhere (19,23).…”

Section: Introductionmentioning

confidence: 99%

Altered Cardiovascular Responses to Exercise in Type 1 Diabetes

Samora

Grotle

Stone

2023

Exercise and Sport Sciences Reviews

View full text Add to dashboard Cite

Exaggerated cardiovascular responses to exercise increase the risk of myocardial infarction and stroke in individuals with type 1 diabetes (T1D); however, the underlying mechanisms remain largely elusive. This review provides an overview of the altered exercise pressor reflex in T1D, with an emphasis on the mechanical component of the reflex. Key Words: exercise pressor reflex, type 1 diabetes, cardiovascular system, neural control of circulation, blood pressure KEY POINTS• Type 1 diabetes (T1D) negatively affects the cardiovascular response to exercise, in part, due to alterations in the neural control of the circulation. • The exercise pressor reflex is involved in mediating the altered cardiovascular response to exercise in T1D and its expression seems to change with disease duration, where an exaggerated reflex is seen in the early stage of the disease but not later. • Emerging data suggest that the mechanically sensitive arm of the reflex (i.e., mechanoreflex) contributes to the exaggerated blood pressure response to exercise in T1D, and inhibition of mechano-gated channels reduces or normalizes the reflex. • Given that exercise is a highly recommended treatment strategy in the clinical management of diabetes, understanding the mechanisms contributing to this altered cardiovascular response is urgently needed.

show abstract

“…When the receptors in the free endings in muscle interstitium are stimulated, unmyelinated group IV (predominantly metabosensitive) and myelinated group III (predominantly mechanically sensitive) afferents arising from contracting skeletal muscle are engaged, cardiovascular nuclei in the brainstem are activated and the SNA increases and BP rises (Kaufman, 1996; Mitchell et al, 1983). Using animal models of PAD, a number of signal pathways and receptors are suggested to play a role in regulating the exaggerated exercise pressor reflex, that is, increases in products of oxidative stress and proinflammatory cytokines, and dysfunction of acid‐sensing ion channels (ASICs), purinergic P2Xs, and bradykinin receptors (Liu et al, 2010; Stone & Kaufman, 2015; Teixeira & Vianna, 2022; Xing et al, 2012). Of note, some of mechanisms are found in human studies (Campos et al, 2019; Muller et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Characteristics of acid‐sensing ion channel currents in male rat muscle dorsal root ganglion neurons following ischemia/reperfusion

Qin

2023

Physiological Reports

View full text Add to dashboard Cite

Peripheral artery diseases (PAD) increases muscle afferent nerve‐activated reflex sympathetic nervous and blood pressure responses during exercise (termed as exercise pressor reflex). However, the precise signaling pathways leading to the exaggerated autonomic responses in PAD are undetermined. Considering that limb ischemia/reperfusion (I/R) is a feature of PAD, we determined the characteristics of acid‐sensing ion channel (ASIC) currents in muscle dorsal root ganglion (DRG) neurons under the conditions of hindlimb I/R and ischemia of PAD. In particular, we examined ASIC currents in two distinct subpopulations, isolectin B 4 ‐positive, and B 4 ‐negative (IB4+ and IB4−) muscle DRG neurons, linking to glial cell line‐derived neurotrophic factor and nerve growth factor. In results, ASIC1a‐ and ASIC3‐like currents were observed in IB4− muscle DRG neurons with a greater percentage of ASIC3‐like currents. Hindimb I/R and ischemia did not alter the distribution of ASIC1a and ASIC3 currents with activation of pH 6.7 in IB4+ and IB4− muscle DRG neurons; however, I/R altered the distribution of ASIC3 currents in IB4+ muscle DRG neurons with pH 5.5, but not in IB4− neurons. In addition, I/R and ischemia amplified the density of ASIC3‐like currents in IB4− muscle DRG neurons. Our results suggest that a selective subpopulation of muscle afferent nerves should be taken into consideration when ASIC signaling pathways are studied to determine the exercise pressor reflex in PAD.

show abstract

The exercise pressor reflex: An update

Cited by 27 publications

References 204 publications

Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents

Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents

Altered Cardiovascular Responses to Exercise in Type 1 Diabetes

Characteristics of acid‐sensing ion channel currents in male rat muscle dorsal root ganglion neurons following ischemia/reperfusion

Contact Info

Product

Resources

About