The Existence of the Glucose-6-Phosphate Dehydrogenase Deficiency Trait in Nigeria and Its Clinical Implications

Gilles, H. M.; Taylor, Bernard

doi:10.1080/00034983.1961.11686019

Cited by 50 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was therefore not unexpected that in the population of children with malaria, the frequency of G6PD deficiency among males would be significantly higher than that of females as obtained in the present study. While this study was carried out among children aged 6 months to 12 years (76% were under five years), many of the previous prevalence studies [10,21,22] were performed among mixed populations of children and adults [11,20,21]. This factor may explain the differences in the prevalence rates.…”

Section: Discussionmentioning

confidence: 94%

Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children

Orimadegun

Sodeinde

2011

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency (Gd-) contributes to morbidity and mortality in sub-Saharan Africa but recent data on the interaction between Gd-and malaria among children is scarce. We hypothesised that, being a haemolytic factor, Gdmakes severe malarial anaemia (SMA) more common and even more severe. Methodology: We selected 930 children aged 0.5-12 years attending a reference hospital with microscopically proven falciparum malaria. G6PD and haemoglobin were typed by the fluorescent spot test and electrophoresis, respectively. Molecular typing by PCR and restriction enzyme digestion was also performed on 15% of randomly selected samples. Haematocrit (PCV) values, haemoglobin type, blood group, presence of sickle cell trait (HbAS), and parasite counts were compared between G6PD-normal and deficient children. Results: Prevalence of Gd-was 16.4% and 8.1% among boys and girls with malaria, respectively. Mean PCV was 22.8% in deficient children compared with 21.0% in normal children (p=0.041). In boys, 2.7% of Gd-had PCV ≤10%, as compared to 13.6% in Gd+ (p = 0.005). Similarly, 21.3% of Gd-had PCV ≤15% compared with 39.4% in Gd+ (p=0.003). No such difference was found among girls. Overall, HbAS was typed in 7.6% and was more common in Gd-(13.0%) than in Gd+ (6.8%), but the difference was not statistically significant (p=0.058). The mean parasite counts were significantly lower in Gd-(15477.5/μl) than in Gd+ (19784.4/μl; p=0.013), and it was independent from HbAS. Conclusion: Gd-males but not females were significantly less likely to develop severe malarial anaemia.

show abstract

Section: Discussionmentioning

confidence: 94%

Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children

Orimadegun

Sodeinde

2011

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…However, the hemolytic effect of G6PD deficiency is self-limiting, affecting mainly older erythrocytes than the newly formed ones; thereby establishing a balance between the factors. Thus, the concept of protection from severe malaria or absence thereof remains conflicting101750.…”

Section: Discussionmentioning

confidence: 99%

“…Some researchers also argued that perhaps malaria may not be the only factor affecting the deficiency gene locus16. It remains to be clarified whether a direct association exists between G6PD deficiency and protection from malaria1117. This systematic review and meta-analysis was undertaken to integrate all the informative studies focusing on the association between malaria and genetically determined G6PD deficiency to assess the presence and the extent of this association.…”

mentioning

confidence: 99%

Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis

Mbanefo

Ahmed

Titouna

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency overlaps with malaria endemicity although it predisposes carriers to hemolysis. This fact supports the protection hypothesis against malaria. The aim of this systematic review is to assess the presence and the extent of protective association between G6PD deficiency and malaria. Thirteen databases were searched for papers reporting any G6PD alteration in malaria patients. Twenty-eight of the included 30 studies were eligible for the meta-analysis. Results showed absence of negative association between G6PD deficiency and uncomplicated falciparum malaria (odds ratio (OR), 0.77; 95% confidence interval (CI), 0.59–1.02; p = 0.07). However, this negative association happened in Africa (OR, 0.59; 95% CI, 0.40–0.86; p = 0.007) but not in Asia (OR, 1.24; 95% CI, 0.96–1.61; p = 0.10), and in the heterozygotes (OR, 0.70; 95% CI, 0.57–0.87; p = 0.001) but not the homo/hemizygous (OR, 0.70; 95% CI, 0.46–1.07; p = 0.10). There was no association between G6PD deficiency and total severe malaria (OR, 0.82; 95% CI, 0.61–1.11; p = 0.20). Similarly, there was no association with other malaria species. G6PD deficiency can potentially protect against uncomplicated malaria in African countries, but not severe malaria. Interestingly, this protection was mainly in heterozygous, being x-linked thus related to gender.

show abstract

“…ghtcose-6-phosphate dehydrogenase (G6PD) deficiencnl~ and neonatal jaundice has been documented among numerous ethnic~t~~~~s~ Thais,,, 2 Chinese,3-7 Malays, ~6,8.0 °I ndians,!-12, Greeks,13-17 Italians,is, 19 Sephardic Jews,20~ 21 African Negroes 22, 23 and BantUS. 24 Many of these studies have pointed out -that the incidence of severe neonatal jaundice and kernicterus is high among newborn infants with erythrocyte G6PD deficiency.…”

mentioning

confidence: 99%

Severe Hyperbilirubinemia in Thai Newborns in Association With Erythrocyte G6PD Deficiency

Phornphutkul¹,

Whitaker²,

Worathumrong

1969

Clin Pediatr (Phila)

View full text Add to dashboard Cite

The Existence of the Glucose-6-Phosphate Dehydrogenase Deficiency Trait in Nigeria and Its Clinical Implications

Cited by 50 publications

References 9 publications

Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children

Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children

Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis

Severe Hyperbilirubinemia in Thai Newborns in Association With Erythrocyte G6PD Deficiency

Contact Info

Product

Resources

About