The mathematical theories and methods of fractional calculus are relatively mature, which have been widely used in signal processing, control systems, nonlinear dynamics, financial models, etc. The studies of some basic theories of fractional differential equations can provide more understanding of mechanisms for the applications. In this paper, the expression of the Green function as well as its special properties are acquired and presented through theoretical analyses. Subsequently, on the basis of these properties of the Green function, the existence and uniqueness of positive solutions are achieved for a singular p-Laplacian fractional-order differential equation with nonlocal integral and infinite-point boundary value systems by using the method of a nonlinear alternative of Leray–Schauder-type Guo–Krasnoselskii’s fixed point theorem in cone, and the Banach fixed point theorem, respectively. Some existence results are obtained for the case in which the nonlinearity is allowed to be singular with regard to the time variable. Several examples are correspondingly provided to show the correctness and applicability of the obtained results, where nonlinear terms are controlled by the integrable functions 1π(lnt)12(1−lnt)12 and 1π(lnt)34(1−lnt)34 in Example 1, and by the integrable functions θ,θ¯ and φ(v),ψ(u) in Example 2, respectively. The present work may contribute to the improvement and application of the coupled p-Laplacian Hadamard fractional differential model and further promote the development of fractional differential equations and fractional differential calculus.