The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways

Song, Shaoxian; Sun, Tianyong; Ding, Xiangjiu; Gu, Xiufeng; Wang, Yushang; Ma, Xiaoyan; Li, Zixuan; Gao, Haiting; Ge, Shaohua; Feng, Qiang

doi:10.1016/j.jare.2023.04.007

Cited by 13 publications

(6 citation statements)

References 45 publications

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“…Noteworthy is the fact that many of the pro-tumor activities of P. gingivalis and F. nucleatum depend on the capability that the two bacteria have to activate the PI3K/AKT intracellular signaling pathway that is key to OSCC development and progression [39,47,189].…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, circulating OSCC cells may undergo a peculiar, fast-occurring type of apoptosis that is termed "anoikis" [107]. In this regard, the activation of the PI3K/AKT signaling pathway promoted by P. gingivalis [39] or F. nucleatum [47] makes OSCC cells resistant to anoikis [107], thereby effectively favoring OSCC metastasization.…”

Section: Effects Of P Gingivalis and F Nucleatum Leading To Oscc Prog...mentioning

confidence: 99%

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About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview

Ciani,

Libonati,

Dri

et al. 2024

IJMS

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Periodontitis is linked to the onset and progression of oral squamous cell carcinoma (OSCC), an epidemiologically frequent and clinically aggressive malignancy. In this context, Fusobacterium (F.) nucleatum and Porphyromonas (P.) gingivalis, two bacteria that cause periodontitis, are found in OSCC tissues as well as in oral premalignant lesions, where they exert pro-tumorigenic activities. Since the two bacteria are present also in endodontic diseases, playing a role in their pathogenesis, here we analyze the literature searching for information on the impact that endodontic infection by P. gingivalis or F. nucleatum could have on cellular and molecular events involved in oral carcinogenesis. Results from the reviewed papers indicate that infection by P. gingivalis and/or F. nucleatum triggers the production of inflammatory cytokines and growth factors in dental pulp cells or periodontal cells, affecting the survival, proliferation, invasion, and differentiation of OSCC cells. In addition, the two bacteria and the cytokines they induce halt the differentiation and stimulate the proliferation and invasion of stem cells populating the dental pulp or the periodontium. Although most of the literature confutes the possibility that bacteria-induced endodontic inflammatory diseases could impact on oral carcinogenesis, the papers we have analyzed and discussed herein recommend further investigations on this topic.

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Section: Discussionmentioning

confidence: 99%

Section: Effects Of P Gingivalis and F Nucleatum Leading To Oscc Prog...mentioning

confidence: 99%

About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview

Ciani,

Libonati,

Dri

et al. 2024

IJMS

View full text Add to dashboard Cite

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“…Studies have demonstrated that microbial species can be transmitted from the oral cavity to the gut and that the oral and gut microbiota can interact with each other 11 . Given the association between dental health and both endothelial dysfunction and atherosclerotic disease, the gut may serve as a niche or entry path for hematogenous spread of bacteria that are pathogenic in the oral cavity 36 , 37 . These studies suggest that bacteria in the oral cavity are associated with cardiovascular disease and may spread to the circulation to affect the growth and stability of atherosclerotic plaques.…”

Section: Gut Microbiome In the Onset And Progression Of Atherosclerosismentioning

confidence: 99%

Impact of the gut microbiome on atherosclerosis

Mao,

Kong,

Zang

et al. 2024

mLife

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Atherosclerosis is a chronic inflammatory metabolic disease with a complex pathogenesis. However, the exact details of its pathogenesis are still unclear, which limits effective clinical treatment of atherosclerosis. Recently, multiple studies have demonstrated that the gut microbiota plays a pivotal role in the onset and progression of atherosclerosis. This review discusses possible treatments for atherosclerosis using the gut microbiome as an intervention target and summarizes the role of the gut microbiome and its metabolites in the development of atherosclerosis. New strategies for the treatment of atherosclerosis are needed. This review provides clues for further research on the mechanisms of the relationship between the gut microbiota and atherosclerosis.

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“…Fn fosters hepatic glycolysis and lipid synthesis through the PI3K/Akt/mTOR signaling pathway, thus uplifting plasma lipid concentrations and exacerbating AS in mice [ 150 ]. Fn -infected macrophages exhibit an activation of the PI3K-AKT/MAPK/NF-κB signaling pathway, propelling the inflammatory responses and cholesterol uptake, concurrently reducing lipid excretion, leading to lipid deposition [ 156 ]. Another study revealed that Fn stimulates macrophages to undergo abnormal pro-inflammatory responses, M1 polarization, and cell apoptosis, triggering the release of inflammatory cytokines such as IL-6, IL-1β, IL-17, and TNF-α.…”

Section: Fusobacterium Nucleatummentioning

confidence: 99%

“…In addition, Fn upregulates FABP4 via a JNK-dependent mechanism in macrophages, thereby augmenting lipid uptake by macrophages [98] (Figure 3) (Table 3). Increased plasma TG and cholesterol levels [150,151]; elevated serum levels of IL-6, CRP, and LDL, decreased levels of HDL [152] A positivity rate of 34% in carotid endarterectomy specimens [147]; ruptured cerebral aneurysms [120]; stable CAD [149] Upregulated chemotactic factors and cell adhesion molecules [152] Hepatic cells Glycolysis and lipid synthesis PI3K/Akt/mTOR signaling pathway [150] Monocytes Inflammatory responses PI3K-AKT/MAPK/NF-κB signaling pathway [156] M1 polarization; cell apoptosis cholesterol accumulation modulation of lipid metabolism-related genes including SR-A1, ACAT-1, ABCA1 and ABCG1 [151]; upregulation of FABP4 via a JNK-dependent mechanism [98]…”

Section: Mechanistic Investigations On the Effect Of Fn In Asmentioning

confidence: 99%

The Roles of Periodontal Bacteria in Atherosclerosis

Huang

Xie

et al. 2023

IJMS

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Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susceptibility to AS and CVD. This review concisely outlines several prevalent periodontal pathogens identified within atherosclerotic plaques, including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum. We review the existing epidemiological evidence elucidating the association between these pathogens and AS-related diseases, and the diverse mechanisms for which these pathogens may engage in AS, such as endothelial barrier disruption, immune system activation, facilitation of monocyte adhesion and aggregation, and promotion of foam cell formation, all of which contribute to the progression and destabilization of atherosclerotic plaques. Notably, the intricate interplay among bacteria underscores the complex impact of periodontitis on AS. In conclusion, advancing our understanding of the relationship between periodontal pathogens and AS will undoubtedly offer invaluable insights and potential therapeutic avenues for the prevention and management of AS.

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The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways

Cited by 13 publications

References 45 publications

About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview

About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview

Impact of the gut microbiome on atherosclerosis

The Roles of Periodontal Bacteria in Atherosclerosis

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