The exosomal secretomes of mesenchymal stem cells extracted via 3D-printed lithium-doped calcium silicate scaffolds promote osteochondral regeneration

Lin, Tsung-Li; Lin, Yu‐Chi; Lee, Alvin Kai-Xing; Kuo, Ting-You; Chen, Chengyu; Chen, Kun-Hao; Chou, Yun-Ting; Chen, Yi-Wen; Shie, Ming‐You

doi:10.1016/j.mtbio.2023.100728

Cited by 7 publications

(1 citation statement)

References 61 publications

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“…Furthermore, 3D printing is cost- and time-efficient and can provide design versatility [ 2 , 3 , 4 ]. It can fabricate scaffolds with lattice-like structures, providing weight reduction and ample mechanical strength and stiffness for numerous engineering applications such as automobile, aerospace, and biomedical engineering [ 5 , 6 , 7 ]. Polyurethane (PU) is an important biopolymer widely used in 3D printing applications, especially for coating or as a composite and adhesive material [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Mechanical Properties and Aging Resistance of 3D-Printed Polyurethane through Polydopamine and Graphene Coating

Tung,

Lin,

Chen

et al. 2023

Polymers

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Three-dimensional (3D) printing is a versatile manufacturing method widely used in various industries due to its design flexibility, rapid production, and mechanical strength. Polyurethane (PU) is a biopolymer frequently employed in 3D printing applications, but its susceptibility to UV degradation limits its durability. To address this issue, various additives, including graphene, have been explored to enhance PU properties. Graphene, a two-dimensional carbon material, possesses remarkable mechanical and electrical properties, but challenges arise in its dispersion within the polymer matrix. Surface modification techniques, like polydopamine (PDA) coating, have been introduced to improve graphene’s compatibility with polymers. This study presents a method of 3D printing PU scaffolds coated with PDA and graphene for enhanced UV stability. The scaffolds were characterized through X-ray diffraction, Fourier-transform infrared spectroscopy, mechanical testing, scanning electron microscopy, and UV durability tests. Results showed successful PDA coating, graphene deposition, and improved mechanical properties. The PDA–graphene-modified scaffolds exhibited greater UV resistance over time, attributed to synergistic effects between PDA and graphene. These findings highlight the potential of combining PDA and graphene to enhance the stability and mechanical performance of 3D-printed PU scaffolds.

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Section: Introductionmentioning

confidence: 99%

Enhancing the Mechanical Properties and Aging Resistance of 3D-Printed Polyurethane through Polydopamine and Graphene Coating

Tung,

Lin,

Chen

et al. 2023

Polymers

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Enhanced Mandibular Bone Repair Using Poly Lactic-co-glycolic Acid Combined with Nanohydroxyapatite Scaffold Loaded by Mesenchymal Stromal/Stem Cells and Curcumin in Male Rats

Mokhtarzadegan,

Amini,

Iraji

et al. 2024

ACS Biomater. Sci. Eng.

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This study aimed to investigate the healing effect of a polylactic-co-glycolic acid (PLGA) scaffold containing nanohydroxyapatite (NHA) along with curcumin (CCM), loaded with adipose-derived mesenchymal stem cells (AD-MSCs), on mandibular bone defects. The designed PLGA scaffolds containing NHA were evaluated for their mechanical and structural properties. Forty rats were divided into five groups (n = 8) based on the treatment: Sham, PLGA scaffolds containing NHA, PLGA scaffolds containing NHA + CCM, PLGA scaffolds containing NHA + AD-MSCs, and PLGA scaffolds containing NHA + CCM + AD-MSCs. After 8 weeks' follow-up, mandible bones were isolated for histomorphometry evaluation. Data were analyzed using SPSS version 21, with p-values <0.05 considered statistically significant. SEM evaluation showed that the designed nanocomposite scaffold had 80% porosity. Histomorphometry results indicated a significant difference in osteocyte, osteoblast, bone area, and vascular area parameters in the group treated with scaffolds loaded with AD-MSCs + CCM compared to the other groups (p < 0.05). The PLGA-containing NHA-CCM nanocomposite scaffold demonstrated good porosity and dispersion, suitable for treating bone defects. Rats treated with scaffolds containing AD-MSCs and CCM showed better therapeutic results than the other groups. Further research is needed to evaluate its anti-inflammatory, antioxidant properties, osteogenesis, and therapeutic effects in larger animal models.

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Synergistic effects of astragalus on 3D-printed calcium silicate/poly-ε-caprolactone scaffolds to regulate inflammation/osteogenesis for bone regeneration

Lee,

Lin,

Kuo

et al. 2024

Mater. Adv.

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The exosomal secretomes of mesenchymal stem cells extracted via 3D-printed lithium-doped calcium silicate scaffolds promote osteochondral regeneration

Cited by 7 publications

References 61 publications

Enhancing the Mechanical Properties and Aging Resistance of 3D-Printed Polyurethane through Polydopamine and Graphene Coating

Enhancing the Mechanical Properties and Aging Resistance of 3D-Printed Polyurethane through Polydopamine and Graphene Coating

Enhanced Mandibular Bone Repair Using Poly Lactic-co-glycolic Acid Combined with Nanohydroxyapatite Scaffold Loaded by Mesenchymal Stromal/Stem Cells and Curcumin in Male Rats

Synergistic effects of astragalus on 3D-printed calcium silicate/poly-ε-caprolactone scaffolds to regulate inflammation/osteogenesis for bone regeneration

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