The expanded Global Registry of Acute Coronary Events: Baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes

Goodman, Shaun G.; Huang, Wei; Budaj, Andrzej; Kennelly, Brian M.; Gore, Joel M.; Fox, Keith A.A.; Goldberg, Robert J.; Anderson, Frederick A.

doi:10.1016/j.ahj.2009.06.003

Cited by 174 publications

(119 citation statements)

References 19 publications

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“…11,25 Clopidogrel was prescribed at a higher rate (90%) ( Table 3) than seen across other registries (50%e80%). 18,19 This is in line with updated 2007 recommendation of dual antiplatelet therapy in ACS, which has proven to confer a 20% reduction in cardiovascular events in both low and high risk patients. 26,27 The utilization of anticoagulants at 78% among ACS patients was similar to patterns observed in other Indian studies (75%e85%).…”

Section: Utilization Patterns Of Cardiovascular Drugs Among Cad and Nsupporting

confidence: 54%

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Patterns and determinants of cardiovascular drug utilization in coronary care unit patients of a tertiary care hospital

George

Devi

Kamath

et al. 2014

Journal of Cardiovascular Disease Research

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a b s t r a c tBackground: A wide variation exists in the patterns of pharmacotherapy among patients admitted with cardiovascular diseases. Very few studies have evaluated the potential determinants of drug utilization. Our objective was to evaluate the clinical characteristics and patterns of cardiovascular drug utilization among patients in coronary care unit (CCU) and assess the determinants of cardiovascular drug use among patients with coronary artery disease (CAD). Methods: In this retrospective cohort study, the medical records of CCU patients were reviewed independently by two trained physicians over one year. Patients were analyzed as two groups e those with CAD and without CAD. Multivariate logistic regression was done to identify the determinants of cardiovascular drug utilization in the CAD group. Results: Of 574 patients, 65% were males, 57% were <60 years. The five commonly prescribed drug classes were platelet inhibitors (88.7%), statins (76.3%), ACE-inhibitors/Angiotensin receptor blockers (72%), beta-blockers (58%) and heparin (57%). Poly-pharmacy (>5 drugs) was noticed in 71% of patients. A majority of patients had diagnosis of CAD (72.6%). CAD patients received significantly higher median number of drugs and had longer duration of CCU stay (p < 0.0001). Renal dysfunction for ACE-inhibitors [0.18 (0.09e0.36)], ST-elevation myocardial infarction for calcium channel blockers [0.29 (0.09e0.93)] and brady-arrhythmias for beta-blockers [0.3 (0.2e0.7)] were identified as determinants of decreased drug use in CAD group. Conclusion: Predominance of male gender, age <60 and poly-pharmacy was observed in CCU. Antithrombotics, statins, ACE-inhibitors/Angiotensin receptor blockers and beta-blockers were the most frequently prescribed drugs. Clinical co-morbidities (renal dysfunction, arrhythmias) decreased the utilization of ACE-inhibitors, beta-blockers among CAD patients.

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Section: Utilization Patterns Of Cardiovascular Drugs Among Cad and Nsupporting

confidence: 54%

“…18,19 Early age at onset of CAD has been documented as one of the unique barriers of the optimal management of CAD in India. 20 The alarming rates of hypertension (65%) and diabetes (43%) are a disturbing trend ( Table 2).…”

Section: Demographic and Clinical Characteristicsmentioning

confidence: 99%

Patterns and determinants of cardiovascular drug utilization in coronary care unit patients of a tertiary care hospital

George

Devi

Kamath

et al. 2014

Journal of Cardiovascular Disease Research

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“…[8][9][10] The frequency of retinal breaks in our patients who were taking AC (46%) was significantly lower than the frequency in our patients not taking AC (72%). However, this is still markedly higher than the 2-4% frequency in patients without VH.…”

Section: Discussionmentioning

confidence: 44%

“…Non-steroidal anti-inflammatory drugs (NSAIDs) also have antiplatelet properties, and their use has increased in the treatment of arthritis. [8][9][10][11][12][13][14][15][16][17][18][19] In this study, we examine the relationship between systemic anticoagulant and antiplatelet usage and the prevalence of retinal breaks and detachment in patients with VH in the setting of an acute PVD.…”

Section: Introductionmentioning

confidence: 99%

Retinal tears after posterior vitreous detachment and vitreous hemorrhage in patients on systemic anticoagulants

El-Sanhouri

Foster

Petersen

et al. 2011

Eye

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Aims or Purpose To determine the rate of retinal tears (RTs) after posterior vitreous detachment (PVD) and vitreous hemorrhage (VH) in patients on systemic anticoagulants. Methods In all, 260 eyes of 260 patients with an acute PVD and VH were followed for evidence of an RT or detachment. Patients were divided into those taking systemic anticoagulants and those not taking anticoagulants. Results A total of 137 patients (53%) were taking anticoagulants, 123 (47%) were not. Overall, 72% of patients not taking any anticoagulant had evidence of an RT, whereas 46% of patients taking an anticoagulant had an RT (P-value 0.0002). Also, 37% of patients not taking an anticoagulant had a retinal detachment (RD), whereas 23% of patients taking any anticoagulant had an RD (P-value 0.01). Conclusions In patients with an acute PVD and VH using anticoagulants, RTs and RDs were common. Anticoagulation status may be an important contributing factor in predicting the incidence of an RT or detachment.

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“…[6] The Global Registry of Acute Coronary Events (GRACE) was a large, prospective, international registry that led to the creation of a simple eight variable risk score (RS) to predict in-hospital mortality in ACS patients. [7,8] Although the GRACE RS was developed over a decade ago, the most recent guidelines by international societies continue to recommend its use, [9,10] suggesting that GRACE remains a relevant risk stratification tool.…”

Section: Introductionmentioning

confidence: 99%

GRACE risk score: Sex-based validity of in-hospital mortality prediction in Canadian patients with acute coronary syndrome

Gong

Goodman

Brieger

et al. 2017

International Journal of Cardiology

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The expanded Global Registry of Acute Coronary Events: Baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes

Cited by 174 publications

References 19 publications

Patterns and determinants of cardiovascular drug utilization in coronary care unit patients of a tertiary care hospital

Patterns and determinants of cardiovascular drug utilization in coronary care unit patients of a tertiary care hospital

Retinal tears after posterior vitreous detachment and vitreous hemorrhage in patients on systemic anticoagulants

GRACE risk score: Sex-based validity of in-hospital mortality prediction in Canadian patients with acute coronary syndrome

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