The Expanding Clinical Spectrum of Multisystem Disease Associated With Eosinophilia

Kaufman, Lee D.

doi:10.1001/archderm.1997.03890380097015

Cited by 11 publications

(3 citation statements)

References 2 publications

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“…HES) or skin disorders alone (e.g. Wells’ syndrome), all forms are accompanied by a similar mechanism of eosinophil activation via various cytokines such as IL‐5 8 . We could not determine when the peripheral blood eosinophilia occurred in our patient, but continuous eosinophilia might have been present for a long time, possibly related to the bronchial asthma in his childhood and the 7‐year history of recurrent eosinophilic cellulitis‐like skin lesions in the extremities.…”

Section: Discussionmentioning

confidence: 99%

Thromboangiitis obliterans associated with peripheral blood and eosinophilic cellulitis‐like skin lesions

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Thromboangiitis obliterans associated with peripheral blood and eosinophilic cellulitis‐like skin lesions

et al. 2004

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“…3,4,6 Of the series of cytokines, interleukin (IL)-3, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) are known as the mediators of eosinophilopoiesis, 4 and these cytokines also promote the release of ECP from granules in eosinophils. Of these mediators, overproduction of IL-5 by type 2 helper T (Th2) cells is considered to be the major triggering factor of idiopathic eosinophilic disorders.…”

Section: A Case Of Eosinophilic Polymyositis Complicated By Myasthenimentioning

confidence: 99%

“…[2][3][4][5][6] Paraneoplastic optic neuropathy has been reported in a few patients with small-cell lung cancer (SCLC). We report a patient in whom both PPNV and optic neuropathy were the presenting symptoms of SCLC.…”

Section: Small-cell Carcinoma Of the Lung Presenting With Paraneoplasmentioning

confidence: 99%

A case of eosinophilic polymyositis complicated by myasthenia gravis

Ikeda

Tanaka

Mizushima³

et al. 1998

Muscle Nerve

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Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue

et al. 1999

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Overall peritumoural inflammatory cell infiltration is a prognostic variable in solid tumours, but the survival‐related impact of the individual cell types within the infiltrate has still not been fully evaluated and compared with the conventional disease classification. In the present study, the prognostic value of individual white cell counts in the peritumoural inflammatory infiltrate in colorectal cancer was assessed. Intra‐operative tumour tissue samples from 584 patients undergoing elective surgery for colorectal cancer were included. None of the patients received pre‐ or post‐operative adjuvant chemotherapy. Tissue blocks were cut from the periphery of the tumours and embedded in paraffin. All blocks included both tumour tissue and normal bowel tissue. Serial sections of 4 µm were analysed for tumour tissue inflammatory cell infiltration using a computer‐ and video‐assisted microscope, which allowed semi‐automated quantification of cells within a fixed area. Total white cells and individual counts of eosinophils, neutrophils, mast cells, lymphocytes, and plasma cells were evaluated in every tumour specimen. Stratification into four groups with similar numbers of events was used to dichotomize the cell counts with respect to survival. The median observation period was 61 (49–75) months. In a multivariate analysis including Dukes' stage, gender, age, peri‐operative blood transfusion, tumour location, and counts of specific inflammatory cells, only advanced Dukes' stage ( p< 0·0001), high age ( p=0·0003), and tumour location in the rectum predicted poor survival, while high counts of eosinophils ( p=0·006) and mast cells ( p=0·02) predicted good survival. Tumour‐associated eosinophilia and mastocytosis appear to be independent prognostic variables in colorectal cancer. Future studies should investigate the potential biological role of tumour tissue eosinophils and mast cells in the modulation of tumour growth. Copyright © 1999 John Wiley & Sons, Ltd.

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The Expanding Clinical Spectrum of Multisystem Disease Associated With Eosinophilia

Cited by 11 publications

References 2 publications

Thromboangiitis obliterans associated with peripheral blood and eosinophilic cellulitis‐like skin lesions

Thromboangiitis obliterans associated with peripheral blood and eosinophilic cellulitis‐like skin lesions

A case of eosinophilic polymyositis complicated by myasthenia gravis

Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue

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