The experience of Anxiety for people with Parkinson’s disease

Blundell, Emma. K.; Grover, Laura. E.; Stott, Joshua; Schrag, Anette

doi:10.1038/s41531-023-00512-1

Cited by 10 publications

(6 citation statements)

References 69 publications

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“…Actually, they indicate to be involved with the fundamental neurological modifications involved with the condition, which frequently manifest prodromal prior to PD being identified. The most prevalent anxiety-related conditions in PD are panic disorder, a form of generalized anxiety disorder, and social phobia, but several anxiety diseases in PD cannot be categorized into traditional DSM classifications (33).…”

Section: Anxietymentioning

confidence: 99%

Unveiling the Mind: A Comprehensive Review of Psychiatric Disorders in Parkinson’s Disease

Stuparu,

Ciorabai,

Pantu

et al. 2023

ARS Medica Tomitana

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Background/Aim: The primary objective of this research was to evaluate the findings and conclusions presented in existing literature articles pertaining to mental illnesses in patients with Parkinson’s disease. Patients and Methods: The study used a patients and methods approach. The study also comprised studies and papers that provided information on clinical aspects, as well as links and correlations between Parkinson’s disease and mental illnesses. Results: Symptoms of mental disorders are extremely prevalent in PD, but they are frequently undetected, undertreated, and overlooked if not evaluated precisely. Neuropsychiatric disorders of Parkinson’s disease divide into a number of major groups: anxiety and mood disorders, psychosis, behavioral modifications such as sexual disorders, impulse control disorders, dopaminergic medication abuse, and sleeping disorders. Conclusion: The majority of mental health conditions in PD are treatable, and failure to do so has a negative impact. Numerous investigations demonstrate that psychiatric symptoms influence the quality of life more than motor manifestations. Depression seems to be associated with deterioration in cognitive performance, tasks associated with everyday living, and motor performance and might have the greatest influence on the quality of life in PD. Psychosis is the leading cause of caretaker concern and a significant predictor of nursing residence relocation. The objective of therapy for mental illnesses in PD ought to include remission; inadequate treatment must be avoided.

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Section: Anxietymentioning

confidence: 99%

Unveiling the Mind: A Comprehensive Review of Psychiatric Disorders in Parkinson’s Disease

Stuparu,

Ciorabai,

Pantu

et al. 2023

ARS Medica Tomitana

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“…Anxiety represents a highly prevalent and subjectively burdensome non-motor symptom in Parkinson’s disease (PD) ( Blundell et al, 2023 ), with an average prevalence of 31% and a lifetime prevalence reaching up to 49% ( Broen et al, 2016 ; Fan et al, 2022 ). Anxiety often emerges prior to the onset of motor symptoms in PD, suggesting its potential as an early manifestation of the disease ( McGregor and Nelson, 2019 ; Carey et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal faster anxiety progression of GBA variant carriers in the early Parkinson’s disease cohort

Sang,

Ba,

Yang

2024

Front. Neurosci.

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ObjectiveAnxiety symptoms are prevalent neuropsychiatric manifestations in Parkinson’s disease (PD) and impact the development of motor complications. Our aim was to evaluate the association of GBA variants with the anxiety development in early PD cohort.MethodsThis cohort study used data from the Parkinson Progression Marker Initiative. The primary outcome anxiety was assessed by State–Trait Anxiety Inventory (STAI). The association between GBA and longitudinal change in the STAI total score was examined using linear mixed-effects model, and the association between GBA and anxiety progression was examined using Cox survival analysis.ResultsA total of 385 patients with PD were included in this study, 39 of them were GBA variant carriers and 346 were idiopathic PD without GBA variants. Patients with GBA variants had faster annual increase in anxiety score (β = 0.44; 95% CI, 0.18 to 0.71; p < 0.001) and were at higher risk of anxiety progression (HR 1.87; 95% CI, 1.03 to 3.41; p = 0.03,). Higher baseline scores for Scales for Outcomes in Parkinson’s Disease-Autonomic (SCOPA-AUT), which indicated the autonomic dysfunction, also independently predicted faster increase in anxiety score (β = 0.48; 95%CI, 0.19 to 0.69; p < 0.001) and higher incidence of anxiety development (HR = 1.05; 95% CI, 1.01 to 1.08; p = 0.008).InterpretationThese findings suggest that longitudinal anxiety symptoms worsening was faster in PD patients who were GBA variant carriers and have dysautonomia, and this association was enhanced if they have both.

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“…Among these, anxiety, depression, cognitive impairment, and sleep disturbances are notably prevalent, affecting a considerable number of PD patients and significantly diminishing their quality of life 2 . Anxiety in PD (A‐PD) can manifest in diverse forms, such as generalized anxiety disorder, panic disorder, and social anxiety, which not only heighten the complexity of the disease but also lead to increased healthcare utilization and caregiver strain 3 . Furthermore, sleep disturbances in PD, which include insomnia, rapid eye movement sleep behavior disorder, and excessive daytime sleepiness, are equally debilitating.…”

Section: Introductionmentioning

confidence: 99%

Gray matter volume alterations in de novo Parkinson's disease: A mediational role in the interplay between sleep quality and anxiety

He,

Huang,

Sun

et al. 2024

CNS Neurosci Ther

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ObjectiveParkinson's disease (PD) is increasingly recognized for its non‐motor symptoms, among which emotional disturbances and sleep disorders frequently co‐occur. The commonality of neuroanatomical underpinnings for these symptoms is not fully understood. This study is intended to investigate the differences in gray matter volume (GMV) between PD patients with anxiety (A‐PD) and those without anxiety (NA‐PD). Additionally, it seeks to uncover the interplay between GMV variations and the manifestations of anxiety and sleep quality.MethodsA total of 37 A‐PD patients, 43 NA‐PD patients, and 36 healthy controls (HCs) were recruited, all of whom underwent voxel‐based morphometry (VBM) analysis. Group differences in GMV were assessed using analysis of covariance (ANCOVA). Partial correlation between GMV, anxiety symptom, and sleep quality were analyzed. Mediation analysis explored the mediating role of the volume of GMV‐distinct brain regions on the relationship between sleep quality and anxiety within the PD patient cohort.ResultsA‐PD patients showed significantly lower GMV in the fusiform gyrus (FG) and right inferior temporal gyrus (ITG) compared to HCs and NA‐PD patients. GMV in these regions correlated negatively with Hamilton Anxiety Rating Scale (HAMA) scores (right ITG: r = −0.690, p < 0.001; left FG: r = −0.509, p < 0.001; right FG: r = −0.576, p < 0.001) and positively with sleep quality in PD patients (right ITG: r = 0.592, p < 0.001; left FG: r = 0.356, p = 0.001; right FG: r = 0.470, p < 0.001). Mediation analysis revealed that GMV in the FG and right ITG mediated the relationship between sleep quality and anxiety symptoms, with substantial effect sizes accounted for by the right ITG (25.74%) and FG (left: 11.90%, right: 15.59%).ConclusionThis study has shed further light on the relationship between sleep disturbances and anxiety symptoms in PD patients. Given the pivotal roles of the FG and the ITG in facial recognition and the recognition of emotion‐related facial expressions, our findings indicate that compromised sleep quality, under the pathological conditions of PD, may exacerbate the reduction in GMV within these regions, impairing the recognition of emotional facial expressions and thereby intensifying anxiety symptoms.

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The experience of Anxiety for people with Parkinson’s disease

Cited by 10 publications

References 69 publications

Unveiling the Mind: A Comprehensive Review of Psychiatric Disorders in Parkinson’s Disease

Unveiling the Mind: A Comprehensive Review of Psychiatric Disorders in Parkinson’s Disease

Longitudinal faster anxiety progression of GBA variant carriers in the early Parkinson’s disease cohort

Gray matter volume alterations in de novo Parkinson's disease: A mediational role in the interplay between sleep quality and anxiety

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