Research purpose: This study implemented somatosensory music therapy on patients with depressive disorders, and explored the effects of somatosensory music therapy on the degree of depression, positive and negative emotions, intuitive stress and autonomic nervous function of patients. Research method: We collected 66 patients diagnosed with depression from the Department of Psychological Medicine of Henan Provincial People's Hospital, and divided them into a control group and an intervention group according to the random number table, with 33 people in each group. The control group received routine psychiatric treatment and nursing. On the basis of the control group, the intervention group received somatosensory music therapy 3 times a week, 30 min each time, for 4 consecutive weeks. The Hamilton Depression Scale, Positive and Negative Emotion Scale, Perceived Stress Scale, and Heart Rate Variability Index were collected and analyzed at baseline (T0), 2 weeks after treatment (T1) and 4 weeks after treatment (T2). Research results: After 4 weeks of treatment, the HAMD scores of the two groups decreased to varying degrees, and the difference between the groups was statistically significant (p < 0.05). After 4 weeks of treatment, the scores of positive emotions in both groups increased to varying degrees, and the scores of negative emotions increased to varying degrees. The scores decreased to varying degrees, and there were statistically significant differences between the positive and negative emotion groups (p < 0.05). After 4 weeks of treatment, the CPSS scores of the two groups decreased to varying degrees, and the difference between the two groups was statistically significant (p < 0.05). Analyzing the main effect of intervention factors alone, after 4 weeks of treatment, SDNN and RMSSD indexes all increased to varying degrees, and the degree of increase in the intervention group was greater than that in the control group, and the difference between the groups was statistically significant (p < 0.05). Research conclusion: assisting somatosensory music therapy for patients with depressive disorders can improve depressive symptoms, increase positive emotions, reduce negative emotions, and reduce perceived stress. These are beneficial to restore the balance of autonomic nervous system, and are effective for the treatment of depression.