The experiences of insulin use among older people with Type 2 diabetes mellitus: A thematic synthesis

Langerman, Chaya; Forbes, Angus; Robert, Glenn

doi:10.1016/j.pcd.2022.08.008

Cited by 15 publications

(17 citation statements)

References 66 publications

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“…The treatment group before the mice were given alloxan, and the results showed that the blood sugar levels in each group of mice were ≤ 100 mg/dL. This shows that all treatment groups, both the control group and the sample group, did not experience type II diabetes mellitus (Langerman et al, 2022).…”

Section: Resultsmentioning

confidence: 88%

Test the Effectiveness of Grape Seed Extract as an Antidiabetic Drug In Male White Rats Wistar Strain

Ardiantya Sudarsono,

Wibowo,

Sugiyanto

et al. 2023

ihj

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The research aims to know the effectiveness of grape seeds in lowering blood sugar levels in white rats. The research began with grape seed extraction using the maceration method. The results of macerate were given to white rats that were given grape seed extract samples at doses of 75 mg/200 grams BW, 125 mg/200 grams BW, and 250 mg/200 grams BW. The positive control was metformin, and the negative control was given distilled water. All were given treatment for 14 days. On days seven and 14, a blood sugar test was carried out to assess the effectiveness of grape seed extract. The results showed that of the five treatment groups, sample group I (extract at a dose of 75 mg/200 gram BW) and sample group III (extract at a dose of 250 mg/200 gram BW) affected reducing blood sugar levels in rats. This is proven by comparing blood sugar levels after being given alloxan on the seventh day in the two groups, showing better results in reducing blood sugar levels than the other groups. It can be concluded that grape seed extract can properly reduce blood sugar levels in white rats with type II diabetes mellitus.

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Section: Resultsmentioning

confidence: 88%

Test the Effectiveness of Grape Seed Extract as an Antidiabetic Drug In Male White Rats Wistar Strain

Ardiantya Sudarsono,

Wibowo,

Sugiyanto

et al. 2023

ihj

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“…2 Technical issues related to insulin injections and SMBG/ intermittently scanned CGM can be particularly challenging for elderly people with cognitive impairment, compromised dexterity or limited vision, who may need health care support at home for managing their treatment. 3,19 In people with severely impaired health status, both tight glycaemic control or conversely undertreatment of persistent hyperglycaemia, may be harmful and may interfere with the management of geriatric syndromes and comorbid conditions. 20,21 Intensified insulin regimens might increase the difficulty in managing glucose levels and, in particular, might increase the risk of hypoglycaemia in this frail population.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the progressive course of type 2 diabetes, many people require intensification of their treatment at some stage of the disease and initiation of insulin therapy with regimens of incremental complexity 2 . Technical issues related to insulin injections and SMBG/intermittently scanned CGM can be particularly challenging for elderly people with cognitive impairment, compromised dexterity or limited vision, who may need health care support at home for managing their treatment 3,19 . In people with severely impaired health status, both tight glycaemic control or conversely undertreatment of persistent hyperglycaemia, may be harmful and may interfere with the management of geriatric syndromes and comorbid conditions 20,21 .…”

Section: Discussionmentioning

confidence: 99%

Should people with type 2 diabetes treated by multiple daily insulin injections with home health care support be switched to hybrid closed‐loop? The CLOSE AP+ randomized controlled trial

Reznik,

Carvalho,

Fendri

et al. 2023

Diabetes Obesity Metabolism

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AimThe study aim was to evaluate the feasibility, safety and efficacy of automated insulin delivery (AID) assisted by home health care (HHC) services in people with type 2 diabetes unable to manage multiple daily insulin injections (MDI) at home on their own.Patients and MethodsThis was an open label, multicentre, randomized, parallel group trial. In total, 30 adults with type 2 diabetes using MDI and requiring nursing support were randomly allocated to AID or kept their usual therapy over a 12‐week period. Both treatments were managed with the support of HHC services. The primary outcome was the percentage time in the target glucose range of 70‐180 mg/dl (TIR). Secondary outcomes included other continuous glucose monitoring metrics, glycated haemoglobin (HbA1c) levels, daily insulin doses, body weight, and of quality of life scores, fear of hypoglycaemia and satisfaction questionnaires.ResultsAge (69.7 vs. 69.3 years) and HbA1c (9.25 vs. 9.0) did not differ in MDI and AID at baseline. Compared with MDI, AID resulted in a significant increase in TIR by 27.4% [95% CI (15.0‐39.8); p < .001], a decrease in time above range by 27.7% and an unchanged time below range of <1%. A between‐group difference in HbA1c was 1.3% favouring AID. Neither severe hypoglycaemia nor ketoacidosis occurred in either group. Patient and caregiver satisfaction with AID was high.ConclusionsAID combined with tailored HHC services significantly improved glycaemic control with no safety issues in people with type 2 diabetes previously under an MDI regimen with HHC. AID should be considered a safe option in these people when lacking acceptable glucose control.

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“…T2DM patients most likely to develop PIR had a lack of T2DM knowledge, negative self‐perception, attitude barriers, insufficient resources, social stigmatization and fear of side effects (Bahrmann et al, 2014; Gherman et al, 2011; Holmes‐Truscott et al, 2017). The systematic review by Langerman et al (2022) found that older people with T2DM reported seven themes for insulin use included physical impact of insulin, physical capacity to administer insulin, insulin self‐management behaviours, emotional factors, social factors, daily living and personal knowledge/beliefs. Three themes related to clinical practice included addressing physical capacity and ability, supporting social and emotional issues and improving interactions with healthcare professionals.…”

Section: Introductionmentioning

confidence: 99%

Psychological insulin resistance and its impact on self‐management in type II diabetes mellitus patients treated with insulin therapy

Fu,

Lee,

Huang

et al. 2023

Int J of Nursing Practice

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AimsPsychological insulin resistance is a common barrier to initiation and persistence with insulin therapy that affects approximately 42.7% of people living with type II diabetes mellitus, which may negatively impact self‐management. This study aimed to assess patients' levels of psychological insulin resistance and to identify factors associated with self‐management in patients with type II diabetes mellitus treated with insulin therapy.MethodsWe adopted a cross‐sectional design. Subjects from the metabolism and endocrinology outpatient departments of a regional teaching hospital in central Taiwan were recruited by consecutive sampling. Patients were assessed for psychological insulin resistance and self‐management using the barriers to insulin treatment questionnaire and the partners in health scale.ResultsA total of 222 patients with type II diabetes mellitus were recruited. Patients had an average psychological insulin resistance score of 3.14 (maximum of 8). Positive self‐management was associated with insulin therapy injection by patient, fewer expectations regarding positive insulin‐related outcomes, no diabetes‐related complications, less fear of injection and self‐testing, no hypoglycaemia within the previous year, and younger age.ConclusionInsulin therapy injection by patient and no diabetes‐related complications were the most common factors associated with overall self‐management and with each domain of self‐management in patients with type II diabetes mellitus treated with insulin therapy. Insulin therapy education should be offered to improve patients' beliefs about insulin therapy and enhance patients' ability to perform self‐management.

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The experiences of insulin use among older people with Type 2 diabetes mellitus: A thematic synthesis

Cited by 15 publications

References 66 publications

Test the Effectiveness of Grape Seed Extract as an Antidiabetic Drug In Male White Rats Wistar Strain

Test the Effectiveness of Grape Seed Extract as an Antidiabetic Drug In Male White Rats Wistar Strain

Should people with type 2 diabetes treated by multiple daily insulin injections with home health care support be switched to hybrid closed‐loop? The CLOSE AP+ randomized controlled trial

Psychological insulin resistance and its impact on self‐management in type II diabetes mellitus patients treated with insulin therapy

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