The experimental and theoretical assessment of biopartitioning micellar liquid chromatography to mimic the drug‐protein binding of some pain‐relief drugs

Abstract

In this work, biopartitioning micellar liquid chromatography (BMLC) was used to the assessment of affinity binding of 13 pain‐relief drugs to human serum albumin (HSA) molecules. The values of BMLC retention factors were determined by aqueous CTAB solution as mobile phase. Then, these values were correlated to some molecular structural descriptors by using a quantitative structure retention relationship methodology. The statistical quality of the obtained models was evaluated by different validation tests. Also, selected descriptors were correlated with protein–drug binding values and resulted in correlation coefficients higher than 0.8. Results indicated that selected descriptors can address the most important structural features influencing the binding affinity of studied drugs to HSA.

Applying eco‐friendly micellar liquid chromatography for the simultaneous determination of two ternary mixtures utilized for cold treatment using monolithic column

“…[ 38,39 ] Besides, recent research provided a biopartitioning micellar liquid chromatography to mimic the drug‐protein binding of 13 pain‐relief drugs. [ 40 ]…”

“…[38,39] Besides, recent F I G U R E 1 Structure of phenylephrine hydrochloride, ibuprofen, chlorpheniramine maleate, and pseudoephedrine hydrochloride research provided a biopartitioning micellar liquid chromatography to mimic the drug-protein binding of 13 pain-relief drugs. [40] The suggested method aimed to afford an accurate and rapid isocratic MLC method for the separation of two ternary mixtures in their raw materials, synthetic mixtures, and pharmaceutical tablet dosage forms. Different experimental factors were carefully studied and validated according to International Conference on Harmonization (ICH) guidelines to optimize the proposed method.…”