1935
DOI: 10.1084/jem.61.2.173
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The Experimental Production in Dogs of Acute Stomatitis, Associated With Leucopenia and a Maturation Defect of the Myeloid Elements of the Bone Marrow

Abstract: An ulcerative stomatitis associated with leucopenia and granulopenia can be induced in dogs by means of a diet causing black tongue. The decrease of circulating leucocytes is due to a suppression of maturation of the erythropoietic elements of the bone marrow. The changes as a whole have a resemblance to those occurring in human beings with acute agranulocytosis.

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Cited by 25 publications
(2 citation statements)
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“…This syndrome could also be reversed by yeast and by meat. 5 Subsequently, production of yeast-correctible nutritional deficiencies in chicks (factor U) 6" and recognition of growth factors from liver and yeast for Lactobacillus casei (norite eluate factor8) provided sensitive bioassays which led to isolation of folic acid from spinach, 9 eventual identification of the vitamin as pteryolglutamic acid,'o recognition of its polyglutam ate forms, and synthesisY…”
mentioning
confidence: 99%
“…This syndrome could also be reversed by yeast and by meat. 5 Subsequently, production of yeast-correctible nutritional deficiencies in chicks (factor U) 6" and recognition of growth factors from liver and yeast for Lactobacillus casei (norite eluate factor8) provided sensitive bioassays which led to isolation of folic acid from spinach, 9 eventual identification of the vitamin as pteryolglutamic acid,'o recognition of its polyglutam ate forms, and synthesisY…”
mentioning
confidence: 99%
“…Miller (5) and Climenko (6) have published evidence that in animals fed amidopyrine in solution, histological examination of the bone marrow discloses definite pathological changes even though no marked decrease in the numbers of granulocytes in the circulating blood is present. Miller and Rhoads (7), in a study of the hematological changes associated with acute black tongue in dogs, reported that the acute stomatitis was occasionally associated with a decreased number of granulocytes in the peripheral blood. Histological studies of bone marrow removed at the height of the granulopenia revealed a relative decrease of mature hematopoietic elements.…”
mentioning
confidence: 99%