The experimental production of ischemic facial paralysis

McGovern, Francis H.; E, Thompson; Link, Nelson

doi:10.1288/00005537-196608000-00004

Cited by 22 publications

(8 citation statements)

References 13 publications

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“…These include facial paresis induced by the infusion of saline under pressure into the facial sheath 101 and enhancement of such induced paralysis by vasoconstrictors 102 . Previous experiments also suggest that arterial blood flow is paramount in the development of facial neuropraxia and facial paralysis 103,104 . Reducing intraneural blood flow also interferes with the progression of axonal sprouting 105 .…”

Section: Discussionmentioning

confidence: 99%

Plasticity of the Extracranial Facial Nerve

Anand

1997

The Laryngoscope

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Although the expansion properties of peripheral nerves have been a matter of considerable study in recent years, investigations of the plasticity of cranial nerves, including the facial nerve, have been lacking. Clinicians, however, have long recognized the tenacity of facial nerve function in patients with slow-growing benign tumors that enormously distort the nerve. An experimental study was designed to assess whether tissue expansion techniques can be applied to the extracranial portion of the facial nerves of cats. In eight cats the frontozygomatic branch of the facial nerve was expanded by stages in seven sessions over a period of 40 days. The length of the nerve increased an average of 95% without significantly impairing nerve function. Pressure changes in the expander averaged 75 mm Hg during each stage of expansion. Electroneurography was performed after each injection of the expander. Statistical analysis of these data did not show consistent evidence of demyelination or denervation, and all but one cat exhibited a normal blink reflex and had normal electromyographic findings at the end of the experiment. Histologic examination of the expanded nerves, however, did show inflammatory changes, intraneural edema, and occasional demyelination.

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Section: Discussionmentioning

confidence: 99%

Plasticity of the Extracranial Facial Nerve

Anand

1997

The Laryngoscope

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“…An experimental animal model of ischemic facial palsy was first reported by McGovern et al 9,10 Ischemic facial palsy was induced by the injection of a vasoconstrictor into the facial canal. Iritani et al 11 and Kumoi et al 12 created a new ischemic animal model by the selective embolization of the middle meningeal artery in adult cats.…”

Section: Discussionmentioning

confidence: 99%

Impaired Ranvier Node Sodium‐Potassium Adenosine Triphosphatase May Induce Facial Palsy

Kanoh

Sakagami

1996

The Laryngoscope

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To clarify the part of the neuron essential for myelinated nerve conduction, the cytochemical localization of potassium ion (K+)-dependent p-nitrophenylphosphatase (K-NPPase) activity was investigated in the normal and reserpine-treated facial nerve of guinea pigs. In the normal animals, K-NPPase activity was localized to the internodal axolemma and Schmidt-Lanterman incisures. In the Ranvier nodes, enzyme activity was observed along the paranodal and nodal axolemma. In reserpinized nerves, K-NPPase activity was absent along the internodal axolemma and Schmidt-Lanterman incisures. In the Ranvier nodes, however, enzyme activity was detectable only in the nodal axolemma. The reserpinized animals demonstrated no evidence of facial palsy. Because K-NPPase is essential for nerve conduction, these results indicate that the location of enzyme activity in reserpinized animals, namely the nodal axolemma, may be of prime importance in saltatory nerve conduction.

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“…1 Surgical Management.-The most fruitful experiments on the facial nerve have been done in ascertaining the value of the contro¬ versial decompression operation. The riddle of Bell's palsy still needs to be solved, but the increasing interest in facial nerve experimentation will undoubtedly result in a solution to this perplexing problem.…”

Section: Management Of Bell's Palsy Experimental Aspectsmentioning

confidence: 99%

Management of Bell's Palsy: Experimental Aspects

McGovern¹

1969

Archives of Otolaryngology - Head and Neck Surgery

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The experimental production of ischemic facial paralysis

Cited by 22 publications

References 13 publications

Plasticity of the Extracranial Facial Nerve

Plasticity of the Extracranial Facial Nerve

Impaired Ranvier Node Sodium‐Potassium Adenosine Triphosphatase May Induce Facial Palsy

Management of Bell's Palsy: Experimental Aspects

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