The Experimental Production of Mutations

Timoféeff-Ressovsky, N. W.

doi:10.1111/j.1469-185x.1934.tb01255.x

Cited by 61 publications

(2 citation statements)

References 184 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…He points out that there can be no doubt about the occurrence of mutations; it is sufficient to point out the new species Spartina townsendii which arose and spread in our time^It is difficult to imagine that such changes can be spontaneous; we must seek some external cause of their appearance in the environment. In a survey of experiments on obtaining mutations by artificial means, Timofeeff -Ressovsky [1934] showed that the only effective method for inducing mutations is bombardment by short-wave radiation or high-speed electrons. At the same time, numerous experiments on the effect of X rays on the structure of the nucleus indicate that irradiation can also cause cytological changes which can be associated with specific differences.…”

Section: Retention Of the Effects Of X Raysmentioning

confidence: 99%

Plants and X rays, by L.B. Breslavets. Translation by Alena Elbl. Edited by Arnold H. Sparrow.

Breslavets¹

1960

View full text Add to dashboard Cite

co-workers. Changes in rye due to the action of X rays. Changes in hemp due to the action of X rays: changes in size, shape, and color of the leaves, sex, and viability. Evaluation of data obtained by various investigators. Prospects for the formation of new species by experimental means. Chapter 3 INTRACELLULAR CHANGES 57 A brief historical survey. Changes in protoplasm. Changes in the chondriosomes and plastids. Changes in the nucleus. Cytological investigations performed in the electrobiological laboratory by the author and her co-workers on rye, peas, and wheat. The significance of intracellular changes for increases in yield and the obtaining of new species. Polyploidism.

show abstract

Section: Retention Of the Effects Of X Raysmentioning

confidence: 99%

Plants and X rays, by L.B. Breslavets. Translation by Alena Elbl. Edited by Arnold H. Sparrow.

Breslavets¹

1960

View full text Add to dashboard Cite

show abstract

“…Le refroidissement semble augmenter les altérations chromosomi ques (36,22,24,29) comme s'il empêchait le réarrangement des frag ments.…”

Section: Action Du Refroidissement Pendant L'irradiationunclassified

Modification De La Radiosensibilite Du Rat Par Hypothermie Profonde

Hajdukovic¹

1955

Acta Radiologica

View full text Add to dashboard Cite

Effects of morphine sulphate on the germ cells of male mice

Badr

Rabouh

1983

Teratog. Carcinog. Mutagen.

View full text Add to dashboard Cite

The dominant lethal test and the spermatocyte test were used to assess the mutagenic effect of morphine sulphate in male mice. Pregnant females were examined at midterm for the number of corpora lutea and intrauterine contents. The effect of the drug on total embryonic losses was very marked at the 1-, 2-, 3-, and 6-week mating intervals. However, the effect of morphine treatment was much more marked and consistent on preimplantation deaths than on early deaths. The consistently high mutation indices (MI) obtained in different treatment groups implied that morphine specifically affected the early spermatid stage (MI 30,46,77, and 31 for the groups treated with 10, 20, 40, and 60 mg morphine, respectively). High mutation indices in the range of 20-36 were shown by a few other spermatogenic stages but were not systematically exhibited by all groups.The spermatocytes of a second group of treated males were examined 45-50 days after treatment with either morphine or saline. The cytogenetic analysis of spermatocytes at diakinesis-metaphase 1 showed significant increases in the frequency of multivalent configuration, translocation, and autosomal and sex chromosome univalents in the groups treated with morphine, compared with the spontaneous rates of the control group. In general, the different doses of morphine resulted in a total chromosomal aberration frequency of approximately 3-6 times the control value, demonstrating nearly a linear dose-response relationship.The results obtained from both test systems in the mouse suggest that morphine in the doses given is potentially mutagenic in this species and can induce sustained chromosomal aberrations in premeiotic stages.

show abstract

The Experimental Production of Mutations

Cited by 61 publications

References 184 publications

Plants and X rays, by L.B. Breslavets. Translation by Alena Elbl. Edited by Arnold H. Sparrow.

Plants and X rays, by L.B. Breslavets. Translation by Alena Elbl. Edited by Arnold H. Sparrow.

Modification De La Radiosensibilite Du Rat Par Hypothermie Profonde

Effects of morphine sulphate on the germ cells of male mice

Contact Info

Product

Resources

About