The Experimental Use of Lipocaic in the Treatment of Psoriasis

Biochemistry of the Skin: 50 Years in The Journal of Investigative Dermatology

“…Lipid metabolism was a continuing interest in the journal: the clinical effect of lipocaic (a pancreatic extract) on psoriasis [3] and the effect of lecithin feeding on the lipid metabolism in psoriatics were studied [4]. Xanthomas have been of long-term interest, extending throughout the entire history of the journal [5][6][7].…”

Evaluation of pancreatic function in patients with plaque psoriasis

“…Becker et al . published two series of studies with lipocaic in patients suffering from psoriasis [ 12 , 13 ]. The authors believed that successful treatment of psoriasis would depend on maintaining serum lipid levels at the lower limit of normal.…”

“…The authors believed that successful treatment of psoriasis would depend on maintaining serum lipid levels at the lower limit of normal. In the first series of studies, they noted improvement in 4 patients after administration of lipocaic, and no improvement in 2 [ 12 ]. Lipocaic was administered orally to patients in a second series of studies with 23 patients who were followed for 2 to 18 months.…”

“…It has been assumed that lipocaic, a product extracted from the pancreas, possibly a hormone, inhibits fat formation and, when injected in dogs after pancreatectomy, prevents the fatty liver that usually follows pancreatectomy. Becker et al published two series of studies with lipocaic in patients suffering from psoriasis [12,13]. The authors believed that successful treatment of psoriasis would depend on maintaining serum lipid levels at the lower limit of normal.…”