The expert network and electronic portal for children with respiratory and allergic symptoms: rationale and design

Zomer-Kooijker, Kim; Erp, Francine C. van; Balemans, Walter A. F.; Ewijk, Bart E. van; Ent, Cornelis K. van der

doi:10.1186/1471-2431-13-9

Cited by 12 publications

(22 citation statements)

References 34 publications

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“…All children were invited for the electronic portal (EP) before an outpatient visit. The details of the EP have been previously published . In short, the EP is a web‐based system with electronic questionnaires for children and their parents developed to collect information on asthma, allergic rhinitis, food allergy, atopic dermatitis and recurrent respiratory tract infections.…”

Section: Methodsmentioning

confidence: 99%

Perceived triggers of asthma impair quality of life in children with asthma

Kansen

Meijer

et al. 2019

Clin Experimental Allergy

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BackgroundData on the impact of the number and nature of perceived asthma triggers on health‐related quality of life (HRQL) in children are scarce.ObjectiveTo investigate the impact of perceived asthma triggers on both asthma‐specific and generic HRQL in children.MethodsA cross‐sectional study was conducted among children (7‐18 years) with asthma in secondary and tertiary care. Children were screened with electronic questionnaires regarding respiratory and allergic symptoms. Asthma‐specific HRQL was assessed using the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) (score range 1‐7) and generic HRQL using the RAND questionnaire (score range 7‐32). The Kruskal‐Wallis test and one‐way ANOVA were used to test the difference of, respectively, the PAQLQ and RAND scores across the number of perceived asthma triggers (0, 1‐2, 3‐4, or ≥ 5). Univariable and multivariable linear regression analyses were performed to evaluate the association between individual triggers and HRQL.ResultsA total of 527 children with a mean (SD) age of 12.1 (2.9) years were included. Children with a higher number of perceived triggers had significantly lower PAQLQ and RAND scores (ie poorer HRQL). The difference in PAQLQ scores was clinically relevant between children with 0 versus 3‐4 or ≥ 5 triggers and 1‐2 versus ≥ 5 triggers (mean difference 0.66, 1.02 and 0.63, respectively). Especially, non‐allergic triggers (physical exercise, the weather, (cigarette) smoke and emotions) were significantly associated with reduced PAQLQ scores. Emotions and food/drinks were associated with reduced RAND scores.Conclusion and Clinical RelevanceA higher number of perceived triggers of asthma were associated with reduced HRQL in children with asthma. Especially, non‐allergic triggers were associated with reduced HRQL.

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Section: Methodsmentioning

confidence: 99%

Perceived triggers of asthma impair quality of life in children with asthma

Kansen

Meijer

et al. 2019

Clin Experimental Allergy

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“…The PACMAN study was approved by Medical Ethics Committee of the University Medical Centre Utrecht. Written, informed consent for all participants in the study was obtained from either the participants themselves or, where participants were minors, a parent or guardian …”

Section: Methodsmentioning

confidence: 99%

Atopic dermatitis characteristics and medication-use patterns in school-age children with AD and asthma symptoms

et al. 2017

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“…Based on their initial answers, the participants will then be prompted by the system to complete additional disease-topic specific questionnaires [33]. …”

Section: Methodsmentioning

confidence: 99%

“…The online questionnaire is located in a patient portal (‘The Electronic Portal for children with respiratory and allergic symptoms’) developed by the Wilhelmina Children’s Hospital. The rationale and design of the Electronic Portal has been previously published [33]. …”

Section: Methodsmentioning

confidence: 99%

Inflammatory phenotypes underlying uncontrolled childhood asthma despite inhaled corticosteroid treatment: rationale and design of the PACMAN2 study

et al. 2013

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BackgroundThe diagnosis of childhood asthma covers a broad spectrum of pathological mechanisms that can lead to similarly presenting clinical symptoms, but may nonetheless require different treatment approaches. Distinct underlying inflammatory patterns are thought to influence responsiveness to standard asthma medication.Methods/designThe purpose of the PACMAN2 study is to identify inflammatory phenotypes that can discriminate uncontrolled childhood asthma from controlled childhood asthma by measures in peripheral blood and exhaled air. PACMAN2 is a nested, case–control follow-up study to the ongoing pharmacy-based “Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects” (PACMAN) study. The original PACMAN cohort consists of children aged 4–12 years with reported use of asthma medication. The PACMAN2 study will be conducted within the larger PACMAN cohort, and will focus on detailed phenotyping of a subset of the PACMAN children. The selected participants will be invited to a follow-up visit in a clinical setting at least six months after their baseline visit based on their adherence to usage of inhaled corticosteroids, their asthma symptoms in the past year, and their age (≥ 8 years). During the follow-up visit, current and long-term asthma symptoms, medication use, environmental factors, medication adherence and levels of exhaled nitric oxide will be reassessed. The following measures will also be examined: pulmonary function, exhaled volatile organic compounds, as well as inflammatory markers in peripheral blood and blood plasma. Comparative analysis and cluster-analyses will be used to identify markers that differentiate children with uncontrolled asthma despite their use of inhaled corticosteroids (ICS) (cases) from children whose asthma is controlled by the use of ICS (controls).DiscussionAsthmatic children with distinct inflammatory phenotypes may respond differently to anti-inflammatory therapy. Therefore, by identifying inflammatory phenotypes in children with the PACMAN2 study, we may greatly impact future personalised treatment strategies, uncover new leads for therapeutic targets and improve the design of future clinical studies in the assessment of the efficacy of novel therapeutics.

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The expert network and electronic portal for children with respiratory and allergic symptoms: rationale and design

Cited by 12 publications

References 34 publications

Perceived triggers of asthma impair quality of life in children with asthma

Perceived triggers of asthma impair quality of life in children with asthma

Atopic dermatitis characteristics and medication-use patterns in school-age children with AD and asthma symptoms

Inflammatory phenotypes underlying uncontrolled childhood asthma despite inhaled corticosteroid treatment: rationale and design of the PACMAN2 study

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