The exposure assessment for veterinary medicinal products

Montforts, Mark; Kalf, Dennis F.; Vlaardingen, P.L.A. van; Linders, Jan

doi:10.1016/s0048-9697(98)00338-6

Cited by 86 publications

(40 citation statements)

References 14 publications

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“…Intriguingly, neither an accumulation of sul genes nor an accumulation of easily extractable SDZ (6) was observed in the field soil after repeated application of manure containing SDZ, as observed in a previous microcosm experiment. In this microcosm experiment it was shown that the repeated application of manure, which is common agricultural practice (36), might lead to a gradual accumulation of resistance genes (24). In the field study presented here, the relative abundance of the sul genes decreased over time, concomitantly with decreasing SDZ concentrations, and fell below initial levels in the bulk soils during the 6-month experimental period (Fig.…”

Section: Discussionmentioning

confidence: 56%

Increased Abundance and Transferability of Resistance Genes after Field Application of Manure from Sulfadiazine-Treated Pigs

Jechalke¹,

Kopmann

Rosendahl

et al. 2013

Appl Environ Microbiol

149

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c Spreading manure containing antibiotics in agriculture is assumed to stimulate the dissemination of antibiotic resistance in soil bacterial populations. Plant roots influencing the soil environment and its microflora by exudation of growth substrates might considerably increase this effect. In this study, the effects of manure from pigs treated with sulfadiazine (SDZ), here called SDZ manure, on the abundance and transferability of sulfonamide resistance genes sul1 and sul2 in the rhizosphere of maize and grass were compared to the effects in bulk soil in a field experiment. In plots that repeatedly received SDZ manure, a significantly higher abundance of both sul genes was detected compared to that in plots where manure from untreated pigs was applied. Significantly lower abundances of sul genes relative to bacterial ribosomal genes were encountered in the rhizosphere than in bulk soil. However, in contrast to results for bulk soil, the sul gene abundance in the SDZ manure-treated rhizosphere constantly deviated from control treatments over a period of 6 weeks after manuring, suggesting ongoing antibiotic selection over this period. Transferability of sulfonamide resistance was analyzed by capturing resistance plasmids from soil communities into Escherichia coli. Increased rates of plasmid capture were observed in samples from SDZ manure-treated bulk soil and the rhizosphere of maize and grass. More than 97% of the captured plasmids belonged to the LowGC type (having low G؉C content), giving further evidence for their important contribution to the environmental spread of antibiotic resistance. In conclusion, differences between bulk soil and rhizosphere need to be considered when assessing the risks associated with the spreading of antibiotic resistance.

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Section: Discussionmentioning

confidence: 56%

Increased Abundance and Transferability of Resistance Genes after Field Application of Manure from Sulfadiazine-Treated Pigs

Jechalke¹,

Kopmann

Rosendahl

et al. 2013

Appl Environ Microbiol

149

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show abstract

“…Administered antibiotics are not fully metabolized, leading to their excretion in animal manure (Chiesa et al, 2015). For example, 17e75% of chlortetracycline or 28e76% of tylosin was excreted into manure in unchanged forms (Montforts et al, 1999;Jjemba, 2002). In the environment, soil is the primary receiver of antibiotics used in animal production, mainly through land application of manure (Jechalke et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of composting and soil type on dissipation of veterinary antibiotics in land-applied manures

et al. 2018

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“…However, 17-80% of the antimicrobials administrated to animals are not adsorbed and are excreted through urine and feces (Halling-Sorensen et al, 1998;Montforts et al, 1999). Bacteria exposed to antimicrobials in the gut of animals may develop antimicrobial resistance (Sarmah et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Occurrence of antimicrobials and antimicrobial resistance genes in beef cattle storage ponds and swine treatment lagoons

Zhang

Parker

et al. 2013

Science of The Total Environment

102

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The exposure assessment for veterinary medicinal products

Cited by 86 publications

References 14 publications

Increased Abundance and Transferability of Resistance Genes after Field Application of Manure from Sulfadiazine-Treated Pigs

Increased Abundance and Transferability of Resistance Genes after Field Application of Manure from Sulfadiazine-Treated Pigs

Effect of composting and soil type on dissipation of veterinary antibiotics in land-applied manures

Occurrence of antimicrobials and antimicrobial resistance genes in beef cattle storage ponds and swine treatment lagoons

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