The Expression and Correlation of iNOS and p53 in Oral Squamous Cell Carcinoma

Yang, Lan; Wang, Youyuan; Guo, Lvhua; Wang, Liping; Chen, Wei‐Liang; Shu, Bin

doi:10.1155/2015/637853

Cited by 26 publications

(34 citation statements)

References 26 publications

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“…Therefore, elevated NO concentration in tumors selectively kills healthy cells and allows cancer cells to survive, thereby contributing to tumor progression [27]. A correlative study in oral squamous cell carcinoma patients made a similar observation, where tumors in advanced stages of the disease showed higher NOS expression and lower p53 expression [28]. …”

Section: No: Modulator Of the Tmementioning

confidence: 98%

Nitric Oxide: The Forgotten Child of Tumor Metabolism

2017

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Nitric oxide (NO) is a signaling molecule with pleiotropic physiological roles in normal cells and pathophysiological roles in cancer. NO synthetase expression and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor prognosis of cancer patients. Exogenous NO in the microenvironment facilitates paracrine signaling, mediates immune responses, and triggers angiogenesis. NO regulates posttranslational protein modifications, S-nitrosation, and genome-wide epigenetic modifications that can have both tumor-promoting and tumor-suppressing effects. We review mechanisms that link NO to cancer hallmarks, with a perspective of co-targeting NO metabolism with first-line therapies for improved outcome. We highlight the need for quantitative flux analysis to study NO in tumors.

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Section: No: Modulator Of the Tmementioning

confidence: 98%

Nitric Oxide: The Forgotten Child of Tumor Metabolism

2017

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“…Carcinogenesis is a multistep process that requires an elusive sequence of genetic, epigenetic, and metabolic changes, which produce deregulations in various intracellular signaling pathways. A large number of activities mediated by iNOS/NO may contribute to tumorigenesis, including the induction of cellular damage, increased angiogenesis, reduction of apoptosis, suppression of the immune system, and NO‐direct mutagenesis . In fact, iNOS can modulate each of the changes in cellular activities that are distinctive and specific to the neoplastic cells, independently of or in combination with other signaling pathways …”

Section: Discussionmentioning

confidence: 99%

“…Some authors have demonstrated an ordered increase in iNOS expression from healthy tissue, through epithelial precursor lesions up to OSCC . Others have correlated high levels of iNOS with OSCC locoregional metastasis, angiogenesis, and p53 up‐regulation . Such data suggest an essential role of iNOS in OSCC development and progression.…”

Section: Introductionmentioning

confidence: 97%

“…In recent years, a great interest in the intracellular signaling mechanisms related to nitric oxide (NO)‐induced carcinogenesis has appeared . One of the reasons, why, is the overexpression of nitric oxide synthases (NOSs) seen in many types of malignant tumors, including head and neck lesions . NOS‐family proteins could interfere in a considerable number of activities that may contribute to carcinogenesis, including induction of angiogenesis, reduction of apoptosis, immune system suppression, direct genomic mutagenesis, and/or impairment of protein folding and function .…”

Section: Introductionmentioning

confidence: 99%

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The importance of inducible nitric oxide synthase and nitrotyrosine as prognostic markers for oral squamous cell carcinoma

Servato

Vieira

Faria

et al. 2019

J Oral Pathology Medicine

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Background The prognosis of human cancer depends on the deregulations of many molecular patterns. In recent years, a great interest in the intracellular signaling mechanisms related to nitric oxide (NO)‐induced carcinogenesis has appeared, as one of the most preeminent prognostic markers for many types of neoplasms. In this study, we identify the levels of iNOS and nitrotyrosine in the sample of normal oral mucosa (NOM), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Methods Quantitative polymerase chain reactions (qPCRs) were utilized to detect the NOS2 levels in fresh‐frozen tissue samples of NOM (n = 6), OL (n = 20), and OSCC (n = 15). Moreover, the immunohistochemical method was used to examine the levels of iNOS and nitrotyrosine in 85 cases of OSCC (39 cases without metastases and 46 with metastases), 42 cases of OL, and 16 cases of NOM. Results There are rising tendencies in the iNOS mRNA and protein levels during human oral carcinogenesis. Similar findings were obtained in the nitrotyrosine staining. Furthermore, iNOS and nitrotyrosine immunostaining are associated with several clinical‐pathological features of OSCC (site, presence of metastasis, staging, recidivism, and survival). Conclusions The NO‐signaling pathway plays a vital role in the development and progression of human oral dysplastic and neoplastic diseases. Nitrotyrosine was a significant marker for the discrimination of OSCC prognosis and survival.

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“…Nitric oxide is a gas and also serves as a neurotransmitter and vasodilator 16 .iNOS over expression has also been observed in squamous cell carcinoma 17 .In the progression of squamous cell carcinomas P53 and iNOS expression is strongly co-related 18 .…”

Section: Introductionmentioning

confidence: 99%

ORAL CANCER PREVALENCE & FINDING OF ALARMING CONSEQUENCES AT ONCOLOGY WARD OF PUBLIC HEALTH CARE SECTOR

Ayub¹,

fayyaz²,

arshad³

et al. 2015

Int. Res. J. Pharm.

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Oral cancer is one of the most occurring cancers from 1908.Its prevalence is rapidly increasing day by day and the most commonly occurring type is squamous cell carcinoma from which more than 50,000 patients affected per year around the world. In this study we are going to describe the main consequences of oral cancer along with its prevalence & consequences responsible for oral cancer.This study deals with the some of the main consequences of oral cancer with their percentage of causing oral cancer including tobacco intake,alcohol consumption,smoking, genetically inherited factor,effect of sunlight and use of red chili in higher amount.For the purpose of searching its main consequences the efforts were made which are based on the survey of different hospitals and reading out the case history and profile of more than 100 patients.This survey was conducted in different hospitals, diagnostic and treatment centers of Karachi and as a result of this survey the collective efforts that achieved, revealed that those patients who were habitual of taking tobacco are at higher risk (of about 50%) of developing oral cancer.Then the 2 nd most common factor involved in oral cancer is alcohol consumption of about 30%. Along with these two, several factors are also involved including genetic factor, smoking, sunlight and many more.On the basis of this survey it is concluded that the above mentioned consequences are greatly responsible for oral cancer & its prevalence can be prevented by get rid of the main consequences of oral cancer mentioned in this study.

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The Expression and Correlation of iNOS and p53 in Oral Squamous Cell Carcinoma

Cited by 26 publications

References 26 publications

Nitric Oxide: The Forgotten Child of Tumor Metabolism

Nitric Oxide: The Forgotten Child of Tumor Metabolism

The importance of inducible nitric oxide synthase and nitrotyrosine as prognostic markers for oral squamous cell carcinoma

ORAL CANCER PREVALENCE & FINDING OF ALARMING CONSEQUENCES AT ONCOLOGY WARD OF PUBLIC HEALTH CARE SECTOR

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