The expression and function of long noncoding RNAs in hepatocellular carcinoma

Abstract

With the deepening of the genome project study, attention on noncoding RNAs is increasing. Long noncoding RNAs (lncRNAs) have become a new research hotspot. A growing number of studies have revealed that lncRNAs are involved in tumorigenesis and tumor suppressor pathways. Aberrant expressions of lncRNAs have been found in a variety of human tumors including hepatocellular carcinoma (HCC). In this review, we provide a brief introduction to lncRNA and highlight recent research on the functions and clinical significance of lncRNAs in HCC.

LINC01503 in cancer: from molecular mechanisms to therapeutic implications

“…The mystery of lncRNAs has gradually been unveiled owing to the implication of high-throughput screening technology. A variety of lncRNAs have been elucidated to regulate cancer occurrence and progression through various molecular mechanisms, such as acting as miRNA sponges, interacting with RBPs, and regulating expression of parental genes [ 30 ].…”