The expression and role of lncRNA AX800134 in hepatitis B virus-related hepatocellular carcinoma

Zuo, Kai; Kong, Li; Dong, Xue; Yang, Yanyan; Xie, Linlin

doi:10.1007/s11262-018-1564-1

Cited by 20 publications

(17 citation statements)

References 23 publications

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“…Another study further validated lncRNA AX800134 expression in hepatitis B virus-associated hepatocellular carcinoma and the association between AX800134 upregulation and HBV-induced HCC and revealed its specific mechanism of action. Zuo et al (2018) studied the effects of AX800134 on the growth and survival of liver cancer cells, analyzing the relationship between its upregulation and HBV infection. The results showed that HBV viral protein HBx directly induces expression of AX800134 in HepG2 cells, and proinflammatory cytokine TNFa enhances expression of AX800134; these effects were reversed by the ROS scavenger PDTC (Pan et al, 2016).…”

Section: Ax800134mentioning

confidence: 99%

Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer

Wang

Kang

et al. 2021

Front. Cell. Infect. Microbiol.

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Hepatocellular carcinoma (HCC) is a malignant tumor with the highest mortality rate in the world, and hepatitis B virus (HBV) plays an important role in its development. Long noncoding RNA (lncRNA) is highly related to the inactivation of tumor suppressor genes and the activation of oncogenes in HCC. Researchers have used high-throughput sequencing technology to identify many noncoding transcripts related to the development of HCC and have studied the interaction between these transcripts and DNA, RNA, or protein to determine the relevant mechanism in the development of HCC. In general, the research on lncRNA represents a new field of cancer research, and the imbalance in lncRNA plays an pivotal role in the occurrence of liver cancer. In this review, we summarize some of the dysfunctional lncRNAs in human HCC associated with HBV infection. Their regulatory pathways, functions, and potential molecular mechanisms in the occurrence and development of HCC are discussed.

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Section: Ax800134mentioning

confidence: 99%

Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer

Wang

Kang

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Koduru demonstrated that the high expression of AX800134 closely associated with the malignancy of HC. 31 Additionally, a study indicated that lncRNA taurine upregulated FIGURE 4 CCNE1 is a functional downstream target of miR-30c-2-3p. A, CCNE1 messenger RNA level is decreased in miR-30c-2-3p overexpressed cells.…”

Section: Zhu Et Al Showed That Ccat1mentioning

confidence: 99%

Upregulated LncRNA‐CCAT1 promotes hepatocellular carcinoma progression by functioning as miR‐30c‐2‐3p sponge

Zhang

Cai

Jiang

et al. 2019

Cell Biochemistry & Function

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Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death over the world. It is well studied that long noncoding RNA colon cancer-associated transcript-1 (CCAT1) played important roles in variety of cancers promoting cell proliferation and metastasis by acting as a competing endogenous RNA (ceRNA) of microRNAs. However, whether CCAT1 could regulate HCC by serving as a ceRNA of microRNA remains to be revealed. In this study, we demonstrated that CCAT1 was highly expressed in HCC tissues and remarkably associated with metastasis. With a bioinformatics prediction and functional assay validation, we found a binding site of miR-30c-2-3p on CCAT1, which was important for CCAT1 to promote cell proliferation. Interestingly, we further revealed a novel recognition site for miR-30c-2-3p on the 3′UTR of CCNE1 by mutative method, luciferase assay, and cell viability confirmation. In general, CCAT1 regulate the expression of CCNE1 by acting as a ceRNA to sponge miR-30c-2-3p in regulating the cell proliferation of HCC. These results suggest that CCAT1 may be a new therapy target for HCC in the future.Significance of the study: Our findings may broaden the understanding of the role of CCAT1 in tumorigenesis and may provide a new therapy target for HCC.

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“…For example, Zuo et al found that lncRNA AX800134 was upregulated in HBV-positive HCC compared with HBV-negative HCC. Silencing AX800134 with siRNA interference significantly suppressed the growth and invasion but enhanced spontaneous apoptosis of HBx-expressing HepG2 cells 8. The study of Lv et al revealed that the expression of lncRNA DREH was frequently downregulated in HBV-associated HCC tissues in comparison with adjacent noncancerous hepatic tissues.…”

Section: Introductionmentioning

confidence: 99%

<p>Integrated analysis of lncRNA-associated ceRNA network reveals potential biomarkers for the prognosis of hepatitis B virus-related hepatocellular carcinoma</p>

Li¹,

Zhao²,

Li³

et al. 2019

CMAR

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BackgroundThere is evidence that abnormal expression of lncRNAs is associated with hepatitis B virus (HBV) infection-induced hepatocellular carcinoma (HCC). However, the mechanisms remain not fully elucidated. The study aimed to identify novel lncRNAs and explore their underlying mechanisms based on the ceRNA hypothesis.MethodsThe RNA and miRNA expression profiling in 20 tumor and matched adjacent tissues from HBV–HCC patients were retrieved from the Gene Expression Omnibus database under accession numbers GSE77509 and GSE76903, respectively. Differentially expressed lncRNAs (DELs), miRNAs (DEMs), and genes (DEGs) were identified using the EdgeR package. Protein–protein interaction (PPI) network was constructed for DEGs followed by module analysis. The ceRNA network was constructed based on interaction relationships between miRNAs and mRNAs/lncRNAs. The functions of DEGs were predicted using DAVID and BinGO databases. The prognosis values (overall survival [OS] and recurrence-free survival [RFS]) of ceRNA network genes were determined using The Cancer Genome Atlas (TCGA) data with Cox regression analysis and Kaplan–Meier method.ResultsThe present study screened 643 DELs, 83 DEMs, and 1,187 DEGs. PPI network analysis demonstrated that CDK1 and CCNE1 were hub genes and extracted in functionally related modules. E2F2, CDK1, and CCNE1 were significantly enriched into cell cycle pathway. FAM182B-miR-125b-5p-E2F2 and LINC00346-miR-10a-5p-CDK1/CCNE1 ceRNA axes were obtained by constructing the ceRNA network. Patients with high expressions of DELs and DEGs in the above ceRNA axes had poor OS, while patients with the high expression of DEMs possessed excellent OS. CDK1 was also an RFS-related biomarker, with its high expression predicting poor RFS. The upregulation of LINC00346 and CDK1 but the downregulation of miR-10a-5p in HCC was validated in other microarray datasets and TCGA database.ConclusionThe LINC00346-miR-10a-5p-CDK1 axis may be an important mechanism for HBV-related HCC, and genes in this ceRNA axis may be potential prognostic biomarkers and therapeutic targets.

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The expression and role of lncRNA AX800134 in hepatitis B virus-related hepatocellular carcinoma

Cited by 20 publications

References 23 publications

Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer

Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer

Upregulated LncRNA‐CCAT1 promotes hepatocellular carcinoma progression by functioning as miR‐30c‐2‐3p sponge

<p>Integrated analysis of lncRNA-associated ceRNA network reveals potential biomarkers for the prognosis of hepatitis B virus-related hepatocellular carcinoma</p>

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