2019
DOI: 10.21203/rs.2.18087/v1
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The Expression and Significance of mTORC1 in Diabetic Retinopathy

Abstract: Background: To investigate the expression and significance of mechanistic target of rapamycin complex 1(mTORC1) in diabetic retinopathy(DR), and to find new targets and new methods for the treatment of DR.Methods: A DR rat model was prepared by general feeding combined with intraperitoneal injection of 10% streptozotocin (60 mg/kg). The rats were randomly divided into a control group (NDM group) and diabetes group (DM group).Three months later,the degrees of retinopathy were determined using hematoxylin and eo… Show more

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Cited by 4 publications
(4 citation statements)
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“…MiR-126 is identified as one of the main factors and potential therapeutic targets in DR, which acts upon IRS-1, leading to its upregulation, resulting in suppressed cell invasion and viability [ 117 ]. In the vitreous body tissues in patients with proliferative diabetic retinopathy (PDR) the expression level of miR-126 was significantly lower in the control group compared to stage IV, V, and VI groups, and negatively correlated with VEGF mRNA levels [ 118 ]. It was found that miR-126 reduces experimental DR and suppresses endothelial cell proliferation and migration by targeting polo-like kinase 4 [ 119 ], and that miR-126 stimulates proliferation and inhibits apoptosis in high-glucose-induced HRECs, through the PI3K–AKT pathway [ 129 ].…”
Section: Complications Of Type 2 Diabetes Mellitusmentioning
confidence: 99%
“…MiR-126 is identified as one of the main factors and potential therapeutic targets in DR, which acts upon IRS-1, leading to its upregulation, resulting in suppressed cell invasion and viability [ 117 ]. In the vitreous body tissues in patients with proliferative diabetic retinopathy (PDR) the expression level of miR-126 was significantly lower in the control group compared to stage IV, V, and VI groups, and negatively correlated with VEGF mRNA levels [ 118 ]. It was found that miR-126 reduces experimental DR and suppresses endothelial cell proliferation and migration by targeting polo-like kinase 4 [ 119 ], and that miR-126 stimulates proliferation and inhibits apoptosis in high-glucose-induced HRECs, through the PI3K–AKT pathway [ 129 ].…”
Section: Complications Of Type 2 Diabetes Mellitusmentioning
confidence: 99%
“…In ▶ table 1, we have summarized miR-126 [11,12], miR-211 [13], miR-93 [14][15][16], miR-122 [17], miR-221 [18], miR-27b and miR-320a [8], miR-150-5p, miR-21-3p and miR-30b-5p [19] as biomarkers in DR over the past 5 years. At the same time, we have focused on miRNAs in vitreous humor (VH) of DR, such as miR-126 [20], miR-19a and 27a [21], miR-29a [22,23], miR-93 and 20a [21], and miR-200b [24] in ▶ table 2.…”
Section: Circulating Mirnas As Biomakers In Drmentioning
confidence: 99%
“…Current studies on DR have shown that the core molecule involved in the pathophysiology is vascular endothelial growth factor (VEGF), which can specifically stimulate the proliferation of vascular endothelial cells and promote neovascularization [2] . A great number of studies have confirmed that concentrations of VEGF in the vitreous of DR patients is significantly higher than that of ordinary people [3] , and drugs targeting VEGF have already been developed, one of which were anti-VEGF drugs and it has been widely accepted as a mainstream treatment method yet. However, recent studies discovered that there are many deficiencies in the application of anti-VEGF drugs, such as long-term drug resistance, high cost of treatment, and potential retinal detachment risk caused by intraocular injection [4] .…”
Section: Introductionmentioning
confidence: 99%