The expression and significance of the &lt;i&gt;HOXA7&lt;/i&gt; gene in oral squamous cell carcinoma

Duan, Xin; Chen, Hao; Ma, Hong; Song, Yijun

doi:10.2334/josnusd.16-0634

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…MAMDC2 is known as a target of miR-196a in head and neck squamous cell carcinoma [ 38 ]. As a member of the family of homeobox genes, HOXA7 is associated with cell proliferation, nerve invasion, distant metastasis and degree of tumor differentiation in several cancers [ 24 , 39 – 42 ]. HOXA7 is regulated by several miRNAs, including miR-196 [ 43 – 45 ].…”

Section: Discussionmentioning

confidence: 99%

Constructing cancer patient-specific and group-specific gene networks with multi-omics data

2020

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Background: Cancer is a complex and heterogeneous disease with many possible genetic and environmental causes. The same treatment for patients of the same cancer type often results in different outcomes in terms of efficacy and side effects of the treatment. Thus, the molecular characterization of individual cancer patients is increasingly important to find an effective treatment. Recently a few methods have been developed to construct cancer sample-specific gene networks based on the difference in the mRNA expression levels between the cancer sample and reference samples. Methods: We constructed a patient-specific network with multi-omics data based on the difference between a reference network and a perturbed reference network by the patient. A network specific to a group of patients was obtained using the average change in correlation coefficients and node degree of patient-specific networks of the group. Results: In this paper, we present a new method for constructing cancer patient-specific and group-specific gene networks with multi-omics data. The main differences of our method from previous ones are as follows: (1) networks are constructed with multi-omics (mRNA expression, copy number variation, DNA methylation and microRNA expression) data rather than with mRNA expression data alone, (2) background networks are constructed with both normal samples and cancer samples of the specified type to extract cancer-specific gene correlations, and (3) both patient individual-specific networks and patient group-specific networks can be constructed. The results of evaluating our method with several types of cancer show that it constructs more informative and accurate gene networks than previous methods. Conclusions: The results of evaluating our method with extensive data of seven cancer types show that the difference of gene correlations between the reference samples and a patient sample is a more predictive feature than mRNA expression levels and that gene networks constructed with multi-omics data show a better performance than those with single omics data in predicting cancer for most cancer types. Our approach will be useful for finding genes and gene pairs to tailor treatments to individual characteristics.

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Section: Discussionmentioning

confidence: 99%

Constructing cancer patient-specific and group-specific gene networks with multi-omics data

2020

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“…It would have been ideal to perform additional comparisons and also include normal tissues. Indeed, HOXA7 has been found to be highly expressed in liver cancer (17), ovarian cancer (18), squamous cell carcinoma of the oral cavity (19), and breast cancer (20), and be associated with disease progression in these tumour types. A similar trend for KRT15 (keratin-15) to HOXA7 was reported squamous cell lung carcinoma (21), and colorectal cancer (22).…”

Section: Tgase-4 In Clinical Prostate Cancermentioning

confidence: 99%

Transglutaminase-4 (Prostate Transglutaminase), a Potential Biological Factor and Clinical Indicator for the Diagnosis and Prognosis of Prostate Cancer

Sanders

Jiang

2022

Anticancer Res

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Transglutaminase-4, also known as prostate transglutaminase, is a protein encoded by the TGM4 gene. TGase-4 was thought to be exclusively expressed in the prostate gland and has been suggested to be involved in certain medical conditions, such as infertility and possibly prostate cancer. In recent years, substantial progress has been made in the understanding of this unique protein in prostate cancer, with emerging clinical evidence. The present concise review summarised the current understanding of this intriguing enzyme in prostate cancer and presents an argument that TGase-4 is a useful indicator of both the development and progression of the disease.Like clinical studies, biological-oriented studies on TGase-4 are not extensive. In collaboration with Dr. Richard Ablin of the University of Arizona, we have carried out a number of investigations by creating cell line models from prostate cancer. In this respect, we have generated both overexpression and knockdown models in prostate cancer cells that 291

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Distant metastasis from oral cavity—correlation between histopathology results and primary site

et al. 2020

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The expression and significance of the <i>HOXA7</i> gene in oral squamous cell carcinoma

Cited by 6 publications

References 21 publications

Constructing cancer patient-specific and group-specific gene networks with multi-omics data

Constructing cancer patient-specific and group-specific gene networks with multi-omics data

Transglutaminase-4 (Prostate Transglutaminase), a Potential Biological Factor and Clinical Indicator for the Diagnosis and Prognosis of Prostate Cancer

Distant metastasis from oral cavity—correlation between histopathology results and primary site

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