2023
DOI: 10.3390/ijms24087307
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The Expression Levels of MicroRNAs Differentially Expressed in Sudden Sensorineural Hearing Loss Patients’ Serum Are Unchanged for up to 12 Months after Hearing Loss Onset

Abstract: Sudden sensorineural hearing loss (SSNHL) is an acquired idiopathic hearing loss. Serum levels of small, non-coding RNAs and microRNAs (miRNAs) miR-195-5p/-132-3p/-30a-3p/-128-3p/-140-3p/-186-5p/-375-3p/-590-5p are differentially expressed in SSNHL patients within 28 days of hearing loss onset. This study determines if these changes persist by comparing the serum miRNA expression profile of SSNHL patients within 1 month of hearing loss onset with that of patients 3–12 months after hearing loss onset. We collec… Show more

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“…Among them, PC-5p-38556_39, PC-5p-29163_54, and miR-93-3p showed remarkable differential expression, which might be closely related to the pathogenesis of SSNHL. In addition, the expression levels of serum miR-195-5p/-132-3p/-30a-3p/-128-3p/-140-3p/-186-5p/-375-3p/-590-5p showed a difference after the onset of sudden deafness, and this difference remained unchanged for a year thereafter ( Nunez et al, 2020 ; Abgoon et al, 2023 ).…”
Section: Other Mirnas In Hearing Lossmentioning
confidence: 99%
“…Among them, PC-5p-38556_39, PC-5p-29163_54, and miR-93-3p showed remarkable differential expression, which might be closely related to the pathogenesis of SSNHL. In addition, the expression levels of serum miR-195-5p/-132-3p/-30a-3p/-128-3p/-140-3p/-186-5p/-375-3p/-590-5p showed a difference after the onset of sudden deafness, and this difference remained unchanged for a year thereafter ( Nunez et al, 2020 ; Abgoon et al, 2023 ).…”
Section: Other Mirnas In Hearing Lossmentioning
confidence: 99%