The expression of adiponectin receptors Adipo-R1 and Adipo-R2 is associated with an intestinal histotype and longer survival in gastric carcinoma

Abstract

Intestinal-type GCs often express Adipo-R1/R2 in association with a better prognosis. The presence of these receptors could be exploited for novel anticancer therapies based on ApN addition in GC.

Adiponectin receptors are downregulated in human gastric cancer

“…Recently, Barresi et al [49] examined gastric cancer by immunohistochemistry and showed that AdipoR1 was well stained in tubular adenocarcinoma, but not stained in signet-ring cell carcinoma, and this result is consistent with ours. They reported that AdipoR1 was not stained in normal gastric mucosa, except in intestinal metaplastic mucosa, which is totally different from our result.…”

Association of Adiponectin Receptor (Adipo-R1/-R2) Expression and Colorectal Cancer

“…We have seen contradictory results obtained in previous studies on the association of gastric cancer and Adipo-R1/-R2 expression in relation to survival. While Barresi et al reported a significant association of Adipo-R1/-R2 expression with overall survival, Ayyildiz et al suggested that there is not any such association (Barresi et al, 2009b;Ayyildiz et al, 2014). In the present study, we did not observe a significant relationship between survival and Adipo-R1/-R2 expression in CRC.…”

Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer

“…In humans, AdipoR1 and AdipoR2 have been reported to be expressed in adipocytes (21), skeletal muscle cells (22), vascular smooth muscle cells, macrophages (23), pancreatic β cells (24) and liver (25,26). The expression of adiponectin receptors has also been reported in various cancer tissues (27)(28)(29)(30)(31)(32), although the results are still controversial, and the role of the receptor expression in tumor tissues remains to be elucidated.…”