2010
DOI: 10.1016/j.earlhumdev.2010.07.012
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The expression of aquaporin 8 and aquaporin 9 in fetal membranes and placenta in term pregnancies complicated by idiopathic polyhydramnios

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Cited by 54 publications
(46 citation statements)
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“…; Zhu et al. ), whereas patients with oligohydramnios (AFVs below normal) have reduced AQP1, AQP3, AQP8, and AQP9 mRNA expression (Zhu et al. ; Jiang et al.…”
Section: Introductionmentioning
confidence: 99%
“…; Zhu et al. ), whereas patients with oligohydramnios (AFVs below normal) have reduced AQP1, AQP3, AQP8, and AQP9 mRNA expression (Zhu et al. ; Jiang et al.…”
Section: Introductionmentioning
confidence: 99%
“…The AQPs are known to play a major role in the regulation of water homeostasis in the body and to participate in the regulation of the amniotic volume (19). An expression of AQPs 1, 3, 8, and 9 in chorio-amniotic membranes has already been reported in healthy pregnancy (10); an increase in their expression has been observed in idiopathic polyhydramnios (12)(13)(14). In addition, polyhydramnios is known to frequently be associated with diabetes (5,6).…”
Section: Discussionmentioning
confidence: 99%
“…They have reported an increase in the expression of the AQPs usually found on these membranes at full term. The expression of AQPs 1 (12), 3, and 9 (13) increases in both amnion and chorion; that of AQP8 increases only in the amnion (14). For Mann and coworkers, the increased expression of AQP1 is seen as a mechanism designed to compensate for the increase in volume of the amniotic fluid, rather than causing it (12).…”
mentioning
confidence: 99%
“…However, Mann et al 42 subsequently demonstrated in further studies that, in fact, aquaporin 1 expression is increased in pregnancies complicated by idiopathic polyhydramnios and is likely a compensatory response to the increased fluid volume in humans, rather than a cause. Zhu et al 40 found an increase in the expression of aquaporin 8 in the amnion and aquaporin 9 within the amnion and chorion in the setting of idiopathic hydramnios, which may indicate an adaptive change in the fetal membranes and placenta to potentially regulate the AFV. The exact mechanism by which idiopathic hydramnios develops and is regulated appears to be complex and remains incompletely understood.…”
Section: Etiology Of Polyhydramniosmentioning
confidence: 99%