The expression of cancerous inhibitor protein phosphatase 2A in chronic rhinosinusitis with nasal polyps

Terna, Emma; Luukkainen, Annika; Seppälä, Mika; Renkonen, Risto; Huhtala, Heini; Tommola, Satu; Paavonen, Timo; Kauppi, Paula; Tynninen, Olli; Jeskanen, Leila; Toppila‐Salmi, Sanna

doi:10.1080/00016489.2016.1195918

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…The proportion of nasal polyp eosinophils of all leukocytes was collected from patient records or from the data of microscopically evaluated archival nasal polyp specimens as described. 35 , 36 B.) LM score was evaluated from CT scans by ENT specialists 34 blinded to patient history data.…”

Section: Methodsmentioning

confidence: 99%

Assessing Cut-off Points of Eosinophils, Nasal Polyp, and Lund-Mackay Scores to Predict Surgery in Nasal Polyposis: A Real-World Study

Virkkula

Penttilä

Vento

et al. 2020

Allergy�Rhinol (Providence)

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Background Developing tools to identify chronic rhinosinusitis with nasal polyps (CRSwNP) patients requiring surgical treatment would help clinicians treat patients more effectively. The aim of this retrospective cross-sectional study was to identify cut-off values for eosinophil percentage, nasal polyps (NP), and Lund-Mackay (LM) scores that may predict the need for surgical treatment in Finnish CRSwNP patients. Methods Data of CRSwNP patients (N = 378) undergoing consultation for ESS in 2001–19 were used. Data was collected from patient records and Lund-Mackay scores were determined from sinus computed tomography scans. The percentage of eosinophils was microscopically evaluated from the polyp samples available (n = 81). Associations were analyzed by Mann Whitney U test, and cut-off values by the area under the receiver operating characteristic curve (AUROC). Results ESS was performed to 293 (77.5%) of patients. Polyp eosinophilia was associated significantly with ESS (p = 0.001), whereas peripheral blood eosinophil count, LM- score and endoscopic NP- score were not (p > 0.05). AUROC values (95% CI) for detecting those needing ESS were for polyp eosinophilia 0.71 (0.60–0.83), p = 0.001, for LM score 0.59 (0.50–0.67), p = 0.054; for NP score 0.56 (0.48–0.64), p = 0.17, and for blood eosinophil count 0.68 (0.46–0.90), p = 0.08. With the threshold value of polyp eosinophilia (>25%), the sensitivity and specificity were optimal for detecting the group needing ESS from the group not undergoing ESS. The cut-off value of blood eosinophil count (>0.26 × 109/L) had relatively good, yet statistically insignificant (underpowered), predictive potential. Moderate cut-off values were found for endoscopic LM score (≥14/24) and NP score (≥4/8). Conclusions Polyp eosinophilia (>25%) predicted ESS among Finnish hospital-level CRSwNP patients. A future challenge would be to find less invasive and cost-effective clinical factors predicting uncontrolled CRSwNP.

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Section: Methodsmentioning

confidence: 99%

Assessing Cut-off Points of Eosinophils, Nasal Polyp, and Lund-Mackay Scores to Predict Surgery in Nasal Polyposis: A Real-World Study

Virkkula

Penttilä

Vento

et al. 2020

Allergy�Rhinol (Providence)

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“…Specifically, Pourang et al found that patients with prevalent nasal polyposis are at an increased risk for malignancies of the head and neck, specifically squamous cell carcinoma, compared to individuals without nasal polyposis [16]. Moreover, TGF-β [17], Wnt [18], and Myc [19] pathways have been reported to be associated with CRSsNP and different cancers. is indicates that CRSwNP shares some common pathways with cancer.…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Modules, Hub Genes, and Noncoding RNAs in Chronic Rhinosinusitis with Nasal Polyps by Weighted Gene Coexpression Network Analysis

Zhou

Zhen

Liu

et al. 2020

BioMed Research International

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease with relatively easy recurrence. However, the precise molecular mechanisms of this disease are poorly known. Based on gene sequencing data obtained from the Gene Expression Omnibus (GEO) database, we constructed coexpression networks by weighted gene coexpression network analysis (WGCNA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed by the Database for Annotation, Visualization, and Integrated Discovery (DAVID). The core gene of pathogenesis, CRSwNP, was screened by protein-protein interaction data (PPI) from the HPRD database. Unsupervised clustering was applied to screen hub genes related to the phenotype of CRSwNP. Blue and turquoise modules were found to be most significantly related to the pathogenicity of CRSwNP. Functional enrichment analysis showed that cell proliferation in the blue modules, the apoptotic process in the turquoise module, and the cancer pathway in both modules were mostly significantly correlated with the development of CRSwNP. The noncoding RNAs (long noncoding RNA and microRNA) and the top 10 core genes in each module were found to be associated with the pathogenesis of CRSwNP. A total of nine hub genes were identified to be related to the CRSwNP phenotype. By qRT-PCR analysis, AKT1, CDH1, PIK3R1, CBL, LRP1, MALAT1, and XIST were proven to be associated with the pathogenesis of CRSwNP. AGR2, FAM3D, PIP, DSE, and TMC were identified to be related to the CRSwNP phenotype. Further exploration of these genes will reveal more important information about the mechanisms of CRSwNP.

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“…On histologic examination, CRSwNP exhibits infiltration of numerous inflammatory cells within the sinuses. A complex interaction between inflammatory cells and mediators plays an integral role in the pathogenesis of CRSwNP (Terna et al, 2016;Schleimer, 2017). Tang et al (2021) focused on the pathogenesis of CRSwNP and the role of ASIC1a.…”

Section: Chronic Rhinosinusitismentioning

confidence: 99%

The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target

Wang

Sun

et al. 2022

Front. Pharmacol.

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It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H+-activated cation channel family. Recently, many studies have been conducted on ASIC1a and inflammatory immune diseases. Here, in this review, we will focus on the role of ASIC1a in several inflammatory immune diseases so as to provide new perspectives for clinical treatment.

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The expression of cancerous inhibitor protein phosphatase 2A in chronic rhinosinusitis with nasal polyps

Cited by 6 publications

References 20 publications

Assessing Cut-off Points of Eosinophils, Nasal Polyp, and Lund-Mackay Scores to Predict Surgery in Nasal Polyposis: A Real-World Study

Assessing Cut-off Points of Eosinophils, Nasal Polyp, and Lund-Mackay Scores to Predict Surgery in Nasal Polyposis: A Real-World Study

Identification of Key Modules, Hub Genes, and Noncoding RNAs in Chronic Rhinosinusitis with Nasal Polyps by Weighted Gene Coexpression Network Analysis

The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target

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