The expression of cell adhesion molecules in colorectal cancer tissue and its clinical values

Abstract

The present work focused on the design of a drug delivery system (DDS) based on pH-sensitive hydrogel.The hydrogels were prepared via graft copolymerization of mixtures of acrylic acid (AA) and 2-hydroxy ethyl methacrylate (HEMA) onto starch backbones by a free radical polymerization technique. Sodium bicarbonate (NaHCO 3) was added to function as a foaming agent under acidic conditions, rendering the hydrogels to be porous. The porous structure of the hydrogel was essential in this system to yield a large surface area so that 5-fluorouracil (5-FU) release could be facilitated. The hydrogel, thus prepared, possessed a porous structure as determined by scanning electron microscopy.The water absorbency of the hydrogels was measured in solutions with pH levels ranging from 1 to 13. The starch-based hydrogel exhibited a pH-responsiveness character such that a swelling-deswelling pulsatile behavior was recorded at pH levels of 2 and 7. Using the drug 5-FU as a model molecule, the in vitro controlled drug-release behaviors of these hydrogels were investigated. The results indicate that the main parameter affecting the drug-release behavior of hydrogels is the pH of the solution. The release rate of 5-FU from hydrogel at pH 7.4 was faster than that at pH 1.2 due to the shrinkage of the hydrogel at pH 1.2.These results suggest that a porous hydrogel could potentially be a useful local delivery system to release drugs, primarily at a specific site of body.

The influence of demographics, psychological factors and self-efficacy on symptom distress in colorectal cancer patients undergoing post-surgical adjuvant chemotherapy

“…The consecutive patients included in the study were relatively young and fairly well educated, which may not be representative of all CRC patients in other regions of China. Nevertheless, the mean age of the 252 patients in the present study was 53.3 ± 10.7 years, which is consistent with that of other reports in China (Xing et al, 2012;Chen et al, 2013).…”

Characterization of 99mTc-Resveratrol as a Cancer Targeting Radiopharmaceutical: An In Vitro study

“…Thus, both active and passive internalization modes were observed for 99m Tc-resveratrol in the present study. Several other studies also support our observation where both active and passive cell internalization for trans-resveratrol has been observed in various normal and cancer cell lines including human umbilical vein endothelial cells (HUVECs) [27], SW 480, SW 620, HT 29, HCT 116 human colon carcinoma cells, human leukemic monocyte lymphoma U937 cells, rat non-transformed small intestinal IEC-18 cells [28] and Hep G2 cell line, derived from a human hepatoblastoma [26]. As discussed above, 99m Tc-resveratrol uptake is partly due to an active process.…”

“…According to reports, trans-resveratrol, which is lypophilic in nature, can enter the cells both by active and passive modes. Whereas, passive internalization for trans-resveratrol has been reported to occur through passive diffusion and a carrier-facilitated passive transport, active transport has been reported to occur via receptor mediated endocytosis [26,27]. After initial insertion in the outer plasma membrane lipid bilayer, resveratrol accumulates in lipid rafts, and is taken up by lipid raft dependent, clathrin-independent endocytosis [28].…”

Evaluation of 99m Tc-resveratrol as a colon cancer targeting probe

“…Both carcinoembryonic antigen and TSA, are widely used tumor markers in colorectal malignancy, which are related to invasion potential of CRC (Chen et al . ; Lin et al . ).…”