The expression of cell adhesion molecule (CD44) in mucoepidermoid carcinoma and its prognostic value

Binmadi, Nada O.; El-Sissi, Azza; Elsissi, N.

doi:10.1016/j.oooo.2014.05.101

Cited by 1 publication

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“…In agreement with our findings, membranous CD44 stain was observed in myoepithelial and ductal cells in ex PA specimens (21) . Similarly, CD44 expressions were seen in myoepithelial Ca ex PA specimens; however, there was no expression of the ductal component (23) . Our findings, as well as the above-mentioned findings, confirm the crucial role of myoepithelial cells in growth control within the SGTs.…”

Section: Discussionmentioning

confidence: 84%

Evaluation of CD44 Expression in Malignant Salivary Gland Tumors

et al. 2021

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Purpose:The aim of this study was to assess the presence and correlation of CD44 in selected malignant salivary glands tumors (SGTs), carcinoma ex pleomorphic (Ca ex PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) histopathological variants. Material and Methods: Thirty-five formalin fixed paraffin embedded blocks of both normal and malignant salivary gland specimens were included. Immunohistochemical analysis was employed to assess the expression of CD44. Results: In the present study, comparing all groups revealed that the highest value was recorded in MEC, followed by ACC, then Ca ex PA, while the lowest mean was recorded in normal salivary tissue. ANOVA tests indicated that all groups had statistically significant differences (p=0,00). Comparing all subtypes of ACC revealed a significant difference between solid pattern and cribriform tubular patterns. Also, there is a significant difference between the high and low grades MEC. Conclusion: According to the current study, the pattern of expression of CD44 was correlated with the histopathological variants and serve as tumor behavior indicator.

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Section: Discussionmentioning

confidence: 84%