The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats

Katayama, Seiichi; Ashizawa, Koji; Gohma, Hiroshi; Fukuhara, Tadahiro; Narumi, Kazunori; Tsuzuki, Yasuhiro; Tatemoto, Hideki; Nakada, Tadashi; Nagai, Kenji

doi:10.1016/j.taap.2006.10.003

Cited by 19 publications

(19 citation statements)

References 56 publications

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“…Ihh is positively modulated by progesterone in the uterus during progesterone-induced processes of proliferation, angiogenesis, and decidualization, which are critical for embryo implantation (19). In contrast, Ihh and Dhh are downregulated by estrogens in the uterus (20). Finally, estrogens and androgens have previously been implicated in the negative and positive regulation, respectively, of Shh expression during prostate gland development (21,22).…”

Section: Crosstalk Between Steroids and The Hh Pathwaymentioning

confidence: 99%

Glucocorticoids and neonatal brain injury: the hedgehog connection

Gulino¹,

Smaele²,

Ferretti³

2009

J. Clin. Invest.

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Glucocorticoids (GCs) play a critical role in neural development; however, their prenatal or neonatal therapeutic use can have detrimental effects on the developing brain. In this issue of the JCI, Heine and Rowitch report that the molecular mechanisms underlying these detrimental effects involve the sonic hedgehog (Shh) signaling pathway, a crucial regulator of brain development and neural stem/progenitor cells (see the related study beginning on page 267). They show that GCs suppress Shh-induced proliferation of cerebellar progenitor cells in postnatal mice and that, conversely, Shh signaling is protective against GC-induced neonatal cerebellar injury by inducing the enzyme 11βHSD2, which inactivates the GCs corticosterone and prednisolone, but not dexamethasone. The data provide a rationale for the therapeutic use of 11βHSD2-sensitive GCs, but not dexamethasone, or for the exploitation of the neuroprotective effect of Shh agonists to prevent GCinduced pre-or neonatal brain injury.

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Section: Crosstalk Between Steroids and The Hh Pathwaymentioning

confidence: 99%

Glucocorticoids and neonatal brain injury: the hedgehog connection

Gulino¹,

Smaele²,

Ferretti³

2009

J. Clin. Invest.

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“…Furthermore, Ihh Dhh and the HH target genes, Ptch1, Gli1 and chicken ovalbumin upstream promoter transcription factor II (Coup-TfII) are expressed in the uterus of immature female rats at 20-days of age (Katayama et al, 2006).…”

Section: Hedgehog Signaling Pathway and The Frtmentioning

confidence: 99%

“…and Gli transcription factors -in mice (Lee et al, 2006a;Matsumoto et al, 2002;Takamoto et al, 2002), hamsters (Khatua et al, 2006), rats (Katayama et al, 2006;Kubota et al, 2008;Kubota et al, 2010), and humans (Wei et al, 2010). Cre sequence was inserted into the Pgr locus (Franco et al, 2010b).…”

Section: Ptch1mentioning

confidence: 99%

“…Components of the HH signaling pathway are expressed in the uterus of immature rats (Katayama et al, 2006) and gilts . In addition, expression of Ihh in the luminal and glandular epithelium of the uterus is increased in response to signaling though PGR (Khatua et al, 2006;Lee et al, 2006b;Matsumoto et al, 2002;Takamoto et al, 2002;Wakitani et al, 2008) and expression of Ihh in the epithelium increases before implantation (Kubota et al, 2008;Kubota et al, 2010;Lee et al, 2006a;Wakitani et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Dominant Activation of Hedgehog Signaling Alters Development of the Female Reproductive Tract.

Migone

Ren

Harman

et al. 2010

Biology of Reproduction

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“…Autre exemple d'interaction, celui de la progestérone, capable de moduler la production d'Ihh lors de l'implantation embryonnaire [29]. À l'inverse, les oestrogènes diminuent l'expression de Ihh et Dhh dans l'utérus [30]. Les androgènes et les oestrogènes sont antagonistes : ils induisent et inhibent respectivement l'expression de Shh au cours du développement prostatique [31,32].…”

Section: Effets Cérébraux Délétères Des Glucocorticoïdes Synthétiquesunclassified

Voie de signalisation Sonic Hedgehog et impact des glucocorticoïdes sur le cerveau en développement

Baud

Gressèns

2009

Med Sci (Paris)

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The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats

Cited by 19 publications

References 56 publications

Glucocorticoids and neonatal brain injury: the hedgehog connection

Glucocorticoids and neonatal brain injury: the hedgehog connection

Dominant Activation of Hedgehog Signaling Alters Development of the Female Reproductive Tract.

Voie de signalisation Sonic Hedgehog et impact des glucocorticoïdes sur le cerveau en développement

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