The Expression of Hslo Transcript Is Largely Locally Restricted Following Intracavernous Injection

Day, Nancy S.; Melman, Arnold; Smith, William L.; Santizo, Cristian; Sato, Y; Zhao, Weixin; Day, M.; Chen, Frank C.; Valcic, Mira; Rehman, Jamil; Bakal, Ron; Christ, George J.

doi:10.1097/00005392-199904010-00845

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“…Another approach to treatment of erectile insufficiency due to neuropathy may involve the use of K ϩ channels somatic gene (naked pcDNA/hSLo cDNA) inoculation into the corporeal tissue. Such a possibility is suggested by experiments in which a single intracorporeal injection of this gene restored the streptozotocin-induced decline in erectile capacity in rats in vivo (423), and in which the expression of the transcript was largely confined to the original tissue of injection (the penis) at time points greater than 24 h after inoculation (424). Moreover, the isolation of prostaglandin receptors EP2, EP3I, EP3II, and TP (425) and the isolation of caveolin-1 and caveolin-3 (inhibitors of NOS activity) (426) in the human corporeal tissue may help in designing new therapeutic approaches for management of erectile insufficiency and priapism, respectively.…”

Section: Tissue and Molecular Engineering In Treatment Of Erectile Dymentioning

confidence: 99%

Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment

2001

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This review is designed to help the reproductive endocrinologist integrate his or her professional activity with those of other disciplines including urology, radiology, neurology, and psychology in order to successfully manage all of the inseparable aspects of male sexual and reproductive functioning. Significant advances in the field of male sexual physiology and pathophysiology and new methods of investigation and treatment of male sexual disorders are outlined. The review synthesizes available data on the following: norms of sexual organs, aging and sexuality, role of central and peripheral neurochemicals in each stage of the sexual cycle, role of corporeal smooth muscles in the hemodynamic control of erection and detumescence, influence of psychological factors, drugs, and disease on all aspects of sexual functioning, and use of nocturnal penile tumescence monitoring, imaging investigations, and neurophysiologic studies in the diagnostic workup of males with sexual dysfunction. Clinical algorithms are presented where appropriate. Extensive discussions on newly developed strategies in psychological and behavioral counseling, drug therapy, tissue engineering, nonsurgical devices, and surgical treatments for all forms of sexual disorders are also provided. Lastly, the effect of sexual dysfunction and its treatment on quality of life in affected men is addressed, along with recommendations for future research endeavors.

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Section: Tissue and Molecular Engineering In Treatment Of Erectile Dymentioning

confidence: 99%

Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment

2001

View full text Add to dashboard Cite

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The Expression of Hslo Transcript Is Largely Locally Restricted Following Intracavernous Injection

Cited by 1 publication

References 0 publications

Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment

Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment

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