The expression of lncRNAs EVADR and LUESCC in Colorectal tumor tissues and their association with the CRC risk in an Iranian population

Abstract

Colorectal cancer (CRC) is a prevalent form of cancer that impacts individuals around the world. It is the second most common cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) are a type of regulatory RNA that can impact gene expression. EVADR and LUESCC are tow novel lncRNA specifically expressed in tumors of glandular origin, such as colon.in this study we aimed to investigate the expression of EVADR and LUESCC in Colorectal tumor tissues in Iranian patients. We selected 50 cases of colorectal tumor tissues (FFPE) from individuals with sporadic CRC who were referred from the Pathology Department of Imam Hossein hospital in Tehran, Iran. The study results offer valuable insights into the expression patterns of LUESCC and EVADR lncRNAs in CRC patients. The findings show a significant upregulation of both LUESCC and EVADR lncRNAs in CRC patients compared to normal tissues, with notable fold-change values and statistical significance. The ROC curve analysis further emphasizes the potential diagnostic value of these lncRNAs. Additionally, the differential expression of LUESCC and EVADR lncRNAs in different differentiation groups suggests a potential association between these lncRNAs and CRC tumor grade. The significant increase in expression observed in well, poor, and intermediate differentiation groups compared to normal tissues underscores the potential role of these lncRNAs in CRC progression and aggressiveness. The present study also revealed distinct expression patterns of LUESCC and EVADR lncRNAs in relation to metastasis and fecal occult blood. Overall, these findings shed light on the diagnostic and prognostic potential of LUESCC and EVADR lncRNAs in CRC.