The expression of locomotor sensitization to apomorphine is dependent on time interval between injection and testing

Serotonin and conditioning: Focus on Pavlovian psychostimulant drug conditioning

“…In our most recent studies, we have shown that repeated pairing of the D1/D2 agonist apomorphine, at dose levels that elicit hyper-locomotion with placement in an open-field, generates both context specific cue conditioned hyper-locomotion and context specific sensitized drug induced hyper-locomotion effects [47,49,51,85]. In line with the extant literature, extinction eliminates the conditioned apomorphine hyper-locomotion response but not the sensitized apomorphine hyper-locomotion response.…”