The expression of MLH1 and MSH2 genes among inhabitants of high background radiation area of Ramsar, Iran

Bakhtiari, Elham; Monfared, Ali Shabestani; Niaki, Hale Akhavan; Borzoueisileh, Sajad; Niksirat, Fatemeh; Fattahi, Sadegh; Monfared, M. Kosari

doi:10.1016/j.jenvrad.2019.106012

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…The city of Ramsar, in northern Iran, has the highest level of natural background radiation in the world (up to 260 mGy annually from radon exposure); however, research on the inhabitants of this area discovered no significant prevalence of radiation-related diseases or cancer compared to those in normal background areas [ 62 ]. One study published in 2019 [ 63 ] evaluated the expression of MLH1 and MSH2 genes among the inhabitants and the results showed a significant upregulation of MLH1 in the residents compared to the control group; whilst MSH2 expression showed no significant difference between these two groups. Additionally, the expression of both MLH1 and MSH2 was associated with age and gender as well as the length of residency in the area.…”

Section: Indirect Studies For the Association Of Ls With Radio-sensit...mentioning

confidence: 99%

Potential risks associated with the use of ionizing radiation for imaging and treatment of colorectal cancer in Lynch syndrome patients

Sun¹,

Moquet²,

Ellender³

et al. 2022

Familial Cancer

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The aim of this review is to investigate the literature pertaining to the potential risks of low-dose ionizing radiation to Lynch syndrome patients by use of computed tomography (CT), either diagnostic CT colonography (CTC), standard staging CT or CT surveillance. Furthermore, this review explores the potential risks of using radiotherapy for treatment of rectal cancer in these patients. No data or longitudinal observational studies of the impact of radiation exposure on humans with Lynch syndrome were identified. Limited experimental studies utilizing cell lines and primary cells exposed to both low and high radiation doses have been carried out to help determine radio-sensitivity associated with DNA mismatch repair gene deficiency, the defining feature of Lynch syndrome. On balance, these studies suggest that mismatch repair deficient cells may be relatively radio-resistant (particularly for low dose rate exposures) with higher mutation rates, albeit no firm conclusions can be drawn. Mouse model studies, though, showed an increased risk of developing colorectal tumors in mismatch repair deficient mice exposed to radiation doses around 2 Gy. With appropriate ethical approval, further studies investigating radiation risks associated with CT imaging and radiotherapy relevant doses using cells/tissues derived from confirmed Lynch patients or genetically modified animal models are urgently required for future clinical guidance.

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Section: Indirect Studies For the Association Of Ls With Radio-sensit...mentioning

confidence: 99%

Potential risks associated with the use of ionizing radiation for imaging and treatment of colorectal cancer in Lynch syndrome patients

Sun¹,

Moquet²,

Ellender³

et al. 2022

Familial Cancer

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“…This is suggestive of increased MMR proficiency in such patients and supports our own observation of significantly lower BNMN levels, one month after 131 I therapy, in TC patients carrying the G allele. How the same allele may be associated with decreased function under basal conditions and increased function after IR exposure remains to be explained: MLH1 has been demonstrated to be upregulated upon IR exposure [112,113], it is possible that such upregulation might be more pronounced in G allele carriers, but this is highly speculative. Nevertheless, the high level of significance in our observations (especially when considering the change in MN frequency from baseline) and their cross-validation in independent groups strengthen our conclusions and warrant further studies to clarify this issue.…”

Section: Nbn Rs1805794mentioning

confidence: 99%

Micronuclei Formation upon Radioiodine Therapy for Well-Differentiated Thyroid Cancer: The Influence of DNA Repair Genes Variants

Santos

Silva

et al. 2020

Genes

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Radioiodine therapy with 131I remains the mainstay of standard treatment for well-differentiated thyroid cancer (DTC). Prognosis is good but concern exists that 131I-emitted ionizing radiation may induce double-strand breaks in extra-thyroidal tissues, increasing the risk of secondary malignancies. We, therefore, sought to evaluate the induction and 2-year persistence of micronuclei (MN) in lymphocytes from 26 131I-treated DTC patients and the potential impact of nine homologous recombination (HR), non-homologous end-joining (NHEJ), and mismatch repair (MMR) polymorphisms on MN levels. MN frequency was determined by the cytokinesis-blocked micronucleus assay while genotyping was performed through pre-designed TaqMan® Assays or conventional PCR-restriction fragment length polymorphism (RFLP). MN levels increased significantly one month after therapy and remained persistently higher than baseline for 2 years. A marked reduction in lymphocyte proliferation capacity was also apparent 2 years after therapy. MLH1 rs1799977 was associated with MN frequency (absolute or net variation) one month after therapy, in two independent groups. Significant associations were also observed for MSH3 rs26279, MSH4 rs5745325, NBN rs1805794, and tumor histotype. Overall, our results suggest that 131I therapy may pose a long-term challenge to cells other than thyrocytes and that the individual genetic profile may influence 131I sensitivity, hence its risk-benefit ratio. Further studies are warranted to confirm the potential utility of these single nucleotide polymorphisms (SNPs) as radiogenomic biomarkers in the personalization of radioiodine therapy.

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“…Their concentration depends mainly on local geology and climate (geographic location) [2,3]. There are the so-called High Radiation Background Areas (HBNRAs), where the dose of radiation, due to natural background, is 55-200 times higher than the doses that occur in Normal Background Radiation Areas (NBRAs) [4,5]. Some of the world's HBNRAs are found in Yangjiang (China), Kerala (India), Gurapari (Brazil), Central Bohemia (Czech Republic), Campania (Italy), Podcetrtek (Slovenia), and Tessin (Switzerland) [2,6].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Radiation Situation and the Presence of Heavy Metals in the Soil in the Poleski National Park

Wojtkowski,

Wojtkowska,

Długosz-Lisiecka

et al. 2023

Applied Sciences

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The aim of the research in the Poleski National Park was to determine the concentration of radionuclides and heavy metals in the soil and to evaluate the absorbed dose and the average annual effective dose as a result of external exposure to ground-based radiation sources. The spread of anthropogenic radionuclide concentration in the Poleski National Park was the highest. This is a first-of-its-kind study in Poland. The annual effective dose calculated for the Poleski National Park was over three times higher than the average worldwide value. Soil samples were subjected to mineralization using a TITAN MPS with a rotor. Subsequently, the metals in the obtained solutions were determined using the atomic absorption spectrometry method with flame atomization (AAS FM). The content of copper Cu, nickel Ni, lead Pb, cadmium Cd, and chromium Cr did exceed the average content neither in Europe nor around the world. The soils of the Poleski National Park are characterized by pollution with the tested heavy metals, especially cadmium Cd.

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The expression of MLH1 and MSH2 genes among inhabitants of high background radiation area of Ramsar, Iran

Cited by 7 publications

References 27 publications

Potential risks associated with the use of ionizing radiation for imaging and treatment of colorectal cancer in Lynch syndrome patients

Potential risks associated with the use of ionizing radiation for imaging and treatment of colorectal cancer in Lynch syndrome patients

Micronuclei Formation upon Radioiodine Therapy for Well-Differentiated Thyroid Cancer: The Influence of DNA Repair Genes Variants

Assessment of the Radiation Situation and the Presence of Heavy Metals in the Soil in the Poleski National Park

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