The expression of MMP‐2, MMP‐7, MMP‐9, and TIMP‐1 in chronic rhinosinusitis and nasal polyposis

Can, İlknur; Ceylan, Kürşat; Çaydere, Muzaffer; Samim, Ethem Erdal; Üstün, Hüseyin; Karasoy, Durdu

doi:10.1016/j.otohns.2008.04.032

Cited by 45 publications

(83 citation statements)

References 19 publications

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“…Other studies have also shown increased levels of MMP-9 in nasal polyps [2,4,5,7,18]. Unlike other studies, we could not find statistically significant differences between MMP-9 levels of nasal polyp tissue and healthy nasal tissue.…”

Section: Discussioncontrasting

confidence: 99%

“…Histologically, the presence of large amounts of extracellular fluid, mast cell degranulation and eosinophil has been shown [14,15]. In some studies, the excessive accumulation of ECM has been suggested as a role of nasal polyposis [2]. MMP and TIMP can be found in the extracellular tissue, and are inflammatory mediators.…”

Section: Discussionmentioning

confidence: 99%

“…Different results have been reported in nasal polyps for TIMP-1 levels. Kahveci et al [7] and Watelet [4] reported of high levels of TIMP-1 but Can et al [2] found low levels in comparative studies between TIMP-1 and the control groups in patients with NP. However, Chen et al [18] found no difference in a comparative study.…”

Section: Discussionmentioning

confidence: 99%

“…Excessive production and accumulation of the extracellular matrix (ECM) has been reported playing a role in NP formation [2].…”

Section: Introductionmentioning

confidence: 99%

“…Especially MMP-2 and MMP-9 are in the main structure of the basal membrane. Because of this feature, the relationship between inflammatory diseases has been examined in further investigations [2,4,7,10].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of MMP-9 and TIMP-1 Levels of the Patients with Nasal Polyposis After Corticosteroid Therapies

Cincik

Erkul

Pinar

et al. 2013

Indian J Otolaryngol Head Neck Surg

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The aim of this study is to evaluate the effects of intrapolyp, systemic and local corticosteroid treatment modalities on MMP-9 and TIMP-1 level in polyp tissues. This study included 71 patients and five groups. Group A treated with oral methylprednisolone, Group B, treated with topical steroid spray, Group C treated with intralesional triamcinolone acetonide, Group D patients with nasal polyposis who has not given any medication, Group E had surgery for concha bullosa without nasal polyp disease. Samples from group A were collected endoscopically 1 day after treatment was stopped. Group B samples were collected at the end of the first month. Video guided sample collection from Group C was also performed on the 7th day after treatment. MMP-9 and TIMP-1 levels were measured by Enzyme-linked immunosorbent assay method. When we compared the MMP-9 levels of all groups, there were no significant differences. There was significant difference of TIMP-1 level between Groups C and E (p C-E = 0.0019), however there was no difference among the level of the other groups. When MMP-9/TIMP1 rates of all groups were compared, there were significant difference between Group A and D (p A-D = 0.005) and between Group A and E, also between Group C and E. Our study is the first study to evaluate the effects of different corticosteroid treatment modalities on MMP-9 and TIMP-1 in nasal polyps and concluded that corticosteroid did not do a significant impact on this pathway.Keywords Nasal polyposis Á Matrix metalloproteinase inhibitor Á Matrix metalloproteinase-9 Á Corticosteroid Á Therapy

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Excessive production and accumulation of the extracellular matrix (ECM) has been reported playing a role in NP formation [2].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of MMP-9 and TIMP-1 Levels of the Patients with Nasal Polyposis After Corticosteroid Therapies

Cincik

Erkul

Pinar

et al. 2013

Indian J Otolaryngol Head Neck Surg

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Altered expression of tissue remodeling genes in a mouse model of acute allergic rhinitis

Sautter

Delaney

Trune

2011

Int Forum Allergy Rhinol

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Background Osteogenesis, fibrosis and scarring are prominent pathologic changes resulting from chronic sinonasal inflammation, and these tissue changes may increase the degree of disease symptomatology and the level of surgical difficulty. Members of the Bone Morphogenetic Protein (BMP) and Fibroblast Growth Factor (FGF) families of cytokines and the Matrix Metalloproteinase (MMP) family of endopeptidases are known to regulate tissue remodeling in other disease processes, but their role in acute and chronic sinonasal inflammation remains undefined. Methods A previously described mouse model of acute allergic rhinitis secondary to Aspergillus fumigatis exposure in BALB/C mice was utilized. Intranasal challenge was performed one week following intraperitoneal sensitization with A. fumigatis extract and mice were sacrificed 6 hours (n=8) and 24 hours (n=8) later. Additional mice were intranasally challenged 3× per week and sacrificed at the end of 7 days (n=8) and 21 days (n=8). The snouts were processed for quantitative RT-PCR and compared to untreated controls for mRNA expression of BMP1, 2, 3, 4, 5, 6, 7, 8a, 8b, 9, 10, FGF1, 2, 3, 4, 5, 6, 7, 8, 10 and MMP1a, 2, 3, 7, 8, 9, 12 and 14. Additional 21 day mice were prepared for sinonasal histopathology. Control mice were treated with the same protocol, with intraperitoneal PBS and intranasal PBS substituted for A. fumigatis extract. Untreated mice were used for additional comparison. Results Compared to both the PBS and untreated control groups, statistically significant (p<0.05) up-regulation of MMP8 was observed in the 6 hour time point. Significant down-regulation of MMP8 was observed at 1 week. Significant up-regulation of FGF3 was observed at one week (p<0.05. BMP3 and BMP5 were significantly down-regulated in the 1 week group (p<0.05). The mice exhibited histologic sinonasal changes consistent with allergic inflammation. Conclusion Intranasal exposure to A. fumigatis results in altered expression of several tissue remodeling cytokines at varying time points in the acute allergic rhinitis mouse model. These changes in cytokine regulation may subsequently contribute to sinonasal osteogenesis, scarring and fibrosis as seen in chronic rhinosinusitis.

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Rhinovirus upregulates matrix metalloproteinase‐2, matrix metalloproteinase‐9, and vascular endothelial growth factor expression in nasal polyp fibroblasts

Wang¹,

Kwon²,

Jang³

2009

The Laryngoscope

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The expression of MMP‐2, MMP‐7, MMP‐9, and TIMP‐1 in chronic rhinosinusitis and nasal polyposis

Abstract: Different regulation type of activation of MMPs has been found in these two diseases. If MMP-2 expression is intense in the mucosa, then this ends with polyp formation; if MMP-7 expression is intense, it ends with CRS or stays as CRS.

Cited by 45 publications

References 19 publications

Evaluation of MMP-9 and TIMP-1 Levels of the Patients with Nasal Polyposis After Corticosteroid Therapies

Evaluation of MMP-9 and TIMP-1 Levels of the Patients with Nasal Polyposis After Corticosteroid Therapies

Altered expression of tissue remodeling genes in a mouse model of acute allergic rhinitis

Rhinovirus upregulates matrix metalloproteinase‐2, matrix metalloproteinase‐9, and vascular endothelial growth factor expression in nasal polyp fibroblasts

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