The Expression of NRIP1 and LCOR in Endometrioid Endometrial Cancer

Abstract

Background: The aim of the study was to analyze the expression of nuclear receptor interacting protein 1 (NRIP1) and its partner ligand-dependent nuclear receptor co-repressor (LCOR) in endometrioid endometrial cancer and to investigate their association with estrogen receptor (ER), progesterone receptor (PR), Ki-67, clinicopathological parameters and patient survival. Materials and Methods: Immunohistochemical evaluation was carried out to investigate the subcellular expression of NRIP1 and LCOR in endometrioid endometrial cancer samples. Statistical analysis was used to identify the correlations of NRIP1 and LCOR expression with clinicopathological variables and to estimate the survival rates. Results: Endometrial cancer tissues exhibited higher expression of NRIP1 and LCOR in comparison with the normal tissues. Cytoplasmic LCOR expression was positively associated with ER and PR expression, while cytoplasmic NRIP1 expression was positively associated with ER expression. Moreover, cytoplasmic expression of NRIP1 was positively associated with Ki-67. Conclusion: Our study demonstrated that high cytoplasmic expression of LCOR may predict a longer overall survival of patients with endometrioid endometrial cancer. Patients with tumors expressing low levels of LCOR showed a worse survival compared to those expressing high levels.

Ki67 and E-cadherin Are Independent Predictors of Long-term Survival in Endometrial Carcinoma

“…Flindris et al, finally, have recently reported a very interesting highly significant association between NRIP1 (nuclear receptor interacting protein 1) and Ki67 expression in endometrial cancer (8). In their study, NRIP1 expression was also strongly correlated with myometrial invasion, so that Ki67 expression in endometrial cancer may not only reflect a higher proliferation rate of the tumor cells, but also, indirectly, higher tumor invasiveness.…”

Crosstalk of Redox-Related Subtypes, Establishment of a Prognostic Model and Immune Responses in Endometrial Carcinoma

“…NRIP1 exerts a carcinogenic effect in various solid tumors [ 48 , 49 , 50 ]. Furthermore, NRIP1 is a classical mutated gene in EC cell lines [ 51 ], and its overexpression is a common cause driving EC and advanced myometrial invasion [ 52 , 53 ]. RNA editing levels of ZNF264 are greatly correlated with the clinical outcome of EC [ 54 ].…”