The Expression of Pyroptosis-Related Gene May Influence the Occurrence, Development, and Prognosis of Uterine Corpus Endometrial Carcinoma

Huang, Xiaoling; Li, Yangyi; Li, Jiena; Yang, Xinbin; Xiao, Jianfeng; Xu, Feng

doi:10.3389/fonc.2022.885114

Cited by 6 publications

(1 citation statement)

References 50 publications

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“…Through GCN analysis, groups of genes presenting consistent expression patterns across specific disease conditions were mined, and these genes were often linked with specific biological functions. Currently, GCN analysis has been successfully applied to reveal the molecular basis as well as the drivers of various diseases [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Prediction of Prognosis, Immunotherapy and Chemotherapy with an Immune-Related Risk Score Model for Endometrial Cancer

Wei

Huang

et al. 2023

Cancers

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Endometrial cancer (EC) is the most common gynecologic cancer. The overall survival remains unsatisfying due to the lack of effective treatment screening approaches. Immunotherapy as a promising therapy has been applied for EC treatment, but still fails in many cases. Therefore, there is a strong need to optimize the screening approach for clinical treatment. In this study, we employed co-expression network (GCN) analysis to mine immune-related GCN modules and key genes and further constructed an immune-related risk score model (IRSM). The IRSM was proved effective as an independent predictor of poor prognosis. The roles of IRSM-related genes in EC were confirmed by IHC. The molecular basis, tumor immune microenvironment and clinical characteristics of the IRSM were revealed. Moreover, the IRSM effectiveness was associated with immunotherapy and chemotherapy. Patients in the low-risk group were more sensitive to immunotherapy and chemotherapy than those in the high-risk group. Interestingly, the patients responding to immunotherapy were also more sensitive to chemotherapy. Overall, we developed an IRSM which could be used to predict the prognosis, immunotherapy response and chemotherapy sensitivity of EC patients. Our analysis not only improves the treatment of EC but also offers targets for personalized therapeutic interventions.

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Section: Introductionmentioning

confidence: 99%

Prediction of Prognosis, Immunotherapy and Chemotherapy with an Immune-Related Risk Score Model for Endometrial Cancer

Wei

Huang

et al. 2023

Cancers

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Pyroptosis-associated genes and tumor immune response in endometrial cancer

Gong,

Wang,

You

et al. 2024

Discov Onc

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An analysis of gasdermin family of genes in UCEC with respect to malignancy status, mutation percentages and histologic diagnosis

Berkel

2024

GENOME INSTAB. DIS.

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Pyroptosis is a type of programmed lytic cell death mechanism associated with the activation of in ammasomes and in ammatory caspases, proteolytic cleavage of gasdermin proteins (GSDMA-E and PJVK), resulting in the formation of pores in cellular membranes such as plasma membrane and mitochondrial membranes. Here, I show that GSDMC expression was increased, GSDME (DFNA5) and PJVK (DFNB59) expression were decreased in uterine corpus endometrial carcinoma (UCEC) cells compared to normal endometrial cells. Total percentage of patients affected by mutations in gasdermin family of genes was the highest in UCEC compared to other cancer types. The highest mutation percentage among the members of the protein family was observed for GSDME which also showed the most signi cant difference in the mRNA expression among other family members between tumor and normal samples, possibly pointing to its relatively higher importance in the pathogenesis of UCEC.Gasdermin family of genes (except GSDMA) had higher transcript levels in serous endometrial adenocarcinoma than in endometrioid endometrial adenocarcinoma, demonstrating the histotypedependent expression of the most of gasdermin genes in UCEC. Transcript levels of certain gasdermin family members also differed based on residual tumor status and histologic tumor grade; however, the expression of any gasdermin genes did not change depending on menopause status. This study suggests that a better mechanistic understanding of pyroptotic cell death in uterine corpus endometrial carcinoma might help identify novel therapeutic targets for the management of this gynecological malignancy. Signi cance StatementUterine corpus endometrial carcinoma (UCEC) is the second most common gynecological malignancy.Pyroptosis is a highly immunogenic cell death mechanism with the potential to activate anti-tumor immunity, and it is mediated by pore-forming gasdermin proteins. In this study, I showed that the expression of certain members of the gasdermin family changes in UCEC, and that the percentage of patients affected by mutations in gasdermin family of genes is the highest in UCEC compared to other cancer types, showing the relatively higher importance of pyroptotic cell death in UCEC. Besides, I found that most gasdermin genes show histotype-dependent expression, with potential implications in prognosis. Collectively, this study suggests that pyroptosis needs to be better understood in the context of UCEC.

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The Expression of Pyroptosis-Related Gene May Influence the Occurrence, Development, and Prognosis of Uterine Corpus Endometrial Carcinoma

Cited by 6 publications

References 50 publications

Prediction of Prognosis, Immunotherapy and Chemotherapy with an Immune-Related Risk Score Model for Endometrial Cancer

Prediction of Prognosis, Immunotherapy and Chemotherapy with an Immune-Related Risk Score Model for Endometrial Cancer

Pyroptosis-associated genes and tumor immune response in endometrial cancer

An analysis of gasdermin family of genes in UCEC with respect to malignancy status, mutation percentages and histologic diagnosis

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